ERKEN EVRE MİKOZİS FUNGOİDES’DE NÖTROFİL/LENFOSİT ORANI, TROMBOSİT/LENFOSİT ORANI VE ORTALAMA TROMBOSİT HACMİNİN PROGNOSTİK ÖNEMİ

Year 2019, Volume: 33 Issue: 2, 149 - 157, 27.09.2019

Özlem Özbağçıvan

Abstract

Amaç: Mikozis Fungoides (MF), primer kutan
T hücreli lenfomalar arasında en sık görülen lenfomadır. Erken evrelerde tanı
alan birçok hastada prognoz oldukça iyi olmasına rağmen, bazı hastalarda hızla
ileri evrelere geçiş görülebilmektedir. Son zamanlarda nötrofil/lenfosit oranı
(NLO), trombosit/lenfosit oranı (TLO) ve ortalama trombosit hacmi (OTH)
lenfomalarda prognostik belirteç olarak kullanılmakla birlikte, literatürde
MF’li hastalarda bu konuda veri bulunmamaktadır. 

Gereç ve Yöntem: Dokuz Eylül
Üniversitesi Tıp Fakültesi Deri ve Zührevi Hastalıklar Anabilim Dalı’nda erken
evre MF tanısı koyulan ve en az 5 yıllık izlemi olan olguların verileri
retrospektif olarak taranmıştır.

Bulgular: Çalışmaya dâhil edilen
67 olgunun 15 (%22,4)’inde, hastalığın ileri evrelere geçiş gösterdiği
belirlenmiştir. Vücut yüzey alanında ≥%10 tutulum, lenfopeni varlığı ve artmış
NLO (>2,60) ve TLO’nun (>138,3) kötü prognoz ile ilişkili olduğu, NLO’nun
ise bağımsız bir prognostik belirteç olduğu saptanmıştır.

Sonuç: NLO ve TLO, MF’de erken evrelerdeki
yüksek riskli hastaları belirlemek amacıyla kullanılabilecek kolay ve ucuz bir
tarama yöntemi olabilir.

Keywords

nötrofil, lenfosit, trombosit, trombosit hacmi

Prognostic significance of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and mean platelet volume in the early stage mycosis fungoides

Abstract

Objective:
 Mycosis Fungoides (MF) is the most common lymphoma
among the primary cutaneous T-cell lymphomas. Although the prognosis is
excellent in many patients diagnosed in the early stages, rapid transition to
advanced stages may be seen in some patients. Recently, the
neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean
platelet volume (MPV) have been used as prognostic markers in lymphomas;
however, there is no existing data in literature in patients with MF.

Material
and Method: The data of patients diagnosed with early stage MF
having at least a 5-year follow up in the Skin and Venereal Diseases Department
of Dokuz Eylul University Faculty of Medicine were retrospectively reviewed.

Results: Transition
to the advanced stages of the disease were observed in 15 (22.4%) of the 67
cases included in the study. The involvement ≥10% of the body surface area,
presence of lymphopenia, and increased NLR (>2.60) and PLR (>138.3) were
associated with poor prognosis, and NLR was found to be an independent
prognostic marker.

Conclusion: NLR and PLR
may prove to be a simple and low cost screening method to identify high-risk
patients in early stages of MF.

Keywords

Neutrophil, lymphocyte, platelet, platelet volume

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