D vitamini düzeyi ile paraoksonaz 1 enzim aktivitesi arasındaki ilişki

Year 2019, Volume: 33 Issue: 3, 199 - 206, 06.02.2020

Özge Dokuzlar Mehmet Calan Ali Şişman Sinem Kocaer Fırat Bayraktar

https://doi.org/10.5505/deutfd.2019.63644

Abstract

Amaç: D vitamini eksikliği lipid metabolizması üzerine olumsuz etki
oluşturmakta ve kardiyovasküler riski artırmaktadır. Paraoksonaz-1 (PON1)
enzim aktivitesi, yüksek dansiteli lipoprotein (HDL) aktivitesini belirleyen
faktörlerden birisidir. Bu araştırmada, D vitamin düzeyi ile PON1 aktivitesi
arasında ilişkili olup olmadığının incelenmesi amaçlandı.
Gereç ve Yöntem: Çalışmamıza 18-50 yaş arası, benzer demografik özelliklere
sahip 200 sağlıklı birey alındı. Araştırmaya dahil edilen bireyler serum 25(OH)D
vitamini düzeyine göre D vitamini düzeyi normal (>30 ng/dL), D vitamin
eksikliği olan (20-30 ng/dL), D vitamin yetmezliği olan (10-20 ng/dL) ve derin D
vitamin yetmezliği olan (<10 ng/dL) bireyler olarak 4 gruba ayrıldı. Bu dört grup
arasında PON1 enzim aktivitesi düzeyi karşılaştırıldı. Plazma PON1 enzim
aktivitesi ELISA yöntemi ile ölçüldü.
Bulgular: Araştırmamıza dahil olan bireylerin 132’si kadın ve 68’i erkek idi.
PON1 enzim aktivitesi 4 grup arasında istatistiksel anlamlı bir fark oluşturmadı.
Ayrıca PON1 enzim aktivitesi ile diğer parametreler arasında da herhangi bir
ilişki saptanmadı.
Sonuç: D vitamini düzeyi ile PON1 enzim aktivitesi arasında bir ilişki
saptanmadı.

Keywords

D vitamini eksikliği, HDL kolesterol, lipid metabolizması, Paraoksonaz-1

RELATIONSHIP BETWEEN VITAMIN D LEVEL AND PARAOXONASE 1 ENZYME ACTIVITY

Abstract

Objective: Vitamin D deficiency has a negative effect on lipid metabolism and
increases cardiovascular risk. Paraoxonase-1 (PON1) enzyme activity is one of
the determinants of high-density lipoprotein (HDL) activity. The aim of this
study was to investigate whether vitamin D level and PON1 activity are related.
Material and Method: 200 healthy individuals between 18-50 years of age with
similar demographic characteristics were included. Individuals included in the
study were divided into four groups as vitamin D levels: sufficient (>30 ng/dL),
mild-moderate deficiency (20-30 ng/dL), deficiency (10-20 ng/dL) and severe
deficiency (<10 ng/dL). PON1 enzyme activity of these four groups was
compared. Plasma PON1 enzyme activity was measured by ELISA.
Results: Of the individuals included to this study, 132 were female and 68 were
male. PON1 enzyme activity did not show any statistically significant difference
between these 4 groups. There was not any relationship between PON1 enzyme
activity and other parameters.
Conclusion: There was no relationship between vitamin D levels and PON1
enzyme activity.

Keywords

Vitamin D deficiency, HDL Cholesterol, lipid metabolism, Paraoxonase-1

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