The Use of GLUT-1, Ki-67 and PCNA Antibodies as Immunohistochemical Markers in Histopathological Differential Diagnosis of Psoriasis and Chronic Spongiotic Dermatitits

Year 2021, Volume: 35 Issue: 2, 169 - 178, 30.08.2021

Ali Mızrak

Abstract

ABSTRACT
Introduction: The present study aims to investigate the benefits of the
immunohistochemical antibodies of glucose transporter 1 (GLUT-1), the
nuclear protein Ki-67, and proliferating cell nuclear antigen (PCNA) to
distinguish between psoriasis and chronic spongiotic dermatitits.
Materials and Methods: We evaluated 32 cases of psoriasis and 35 cases of
spongiotic dermatitis that had been clinicopathologically diagnosed. Skin
tissue from reduction mammoplasty procedures was used as a control group.
Skin biopsy sections stained with H&E were examined. Additional
immunohistochemistry was performed, including Ki-67, PCNA and GLUT-1.
Histological findings were also noted
Results: There was no significant difference between psoriasis and chronic
spongiotic dermatitits groups in the results of Ki-67 or PCNA staining. GLUT1 distribution was also similar; however, there was a difference between the
groups concerning GLUT-1 intensity. The percentage of cases with moderate
GLUT-1 staining was higher in the psoriasis group, whereas the percentage
of strong staining was higher in the chronic spongiotic dermatitits group.
Most of the examined histopathological features of psoriasis and chronic
spongiotic dermatitits cases were different.
Conclusion: The intensity of GLUT-1 staining with the appropriate
histopathological and clinical findings may have a limited benefit in the
differential diagnosis of psoriasis and chronic spongiotic dermatitits.

Keywords

chronic spongiotic dermatitits, glucose transporter 1, immunohistochemistry, Ki-67, proliferating cell nuclear antigen, psoriasis

The Use of GLUT-1, Ki-67 and PCNA Antibodies as Immunohistochemical Markers in Histopathological Differential Diagnosis of Psoriasis and Chronic Spongiotic Dermatitits

Abstract

Introduction: The present study aims to investigate the benefits of the
immunohistochemical antibodies of glucose transporter 1 (GLUT-1), the
nuclear protein Ki-67, and proliferating cell nuclear antigen (PCNA) to
distinguish between psoriasis and chronic spongiotic dermatitits.
Materials and Methods: We evaluated 32 cases of psoriasis and 35 cases of
spongiotic dermatitis that had been clinicopathologically diagnosed. Skin
tissue from reduction mammoplasty procedures was used as a control group.
Skin biopsy sections stained with H&E were examined. Additional
immunohistochemistry was performed, including Ki-67, PCNA and GLUT-1.
Histological findings were also noted
Results: There was no significant difference between psoriasis and chronic
spongiotic dermatitits groups in the results of Ki-67 or PCNA staining. GLUT1 distribution was also similar; however, there was a difference between the
groups concerning GLUT-1 intensity. The percentage of cases with moderate
GLUT-1 staining was higher in the psoriasis group, whereas the percentage
of strong staining was higher in the chronic spongiotic dermatitits group.
Most of the examined histopathological features of psoriasis and chronic
spongiotic dermatitits cases were different.
Conclusion: The intensity of GLUT-1 staining with the appropriate
histopathological and clinical findings may have a limited benefit in

Keywords

chronic spongiotic dermatitits, glucose transporter 1, immunohistochemistry, Ki-67, proliferating cell nuclear antigen, psoriasis

References

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