PROSTAT INVOLVEMENT IN BRUCELLOSIS

Abstract

Although brucellosis has a wide range of clinical symptoms and can linger for several days or even years, it is frequently misunderstood, which can lead to ineffective treatment and protracted sickness. Brucellosis may affect the male genitourinary system in some patients. Prostate involvement is very rare. In this review, we aimed to review the literature on prostate involvement of brucellosis.

Keywords

• Brucellosis
• Prostate
• Prostate abscess
• Prostatitis
• Male genitourinary system

BRUSELLOZDA PROSTAT TUTULUMU

Abstract

Bruselloz çok çeşitli klinik semptomlara sahip olmasına ve birkaç gün hatta yıllarca sürebilmesine rağmen, sıklıkla yanlış anlaşılır ve bu da etkisiz tedaviye ve uzun süreli hastalığa yol açabilir. Bruselloz erkek genitoüriner sistemi bazı hastalarda etkileyebilir. Prostat tutulumu ise oldukça nadirdir. Bu derleme çalışmasında, brusellozun prostat tutulumu hakkında literatürü gözden geçirmeyi amaçladık.

Keywords

• Bruselloz
• Prostat
• Prostat absesi
• Prostatit
• Erkek genitoüriner sistem

References

1. 1. Sözen EE, Aksoy F, Aydin K, Köksal I, Yilmaz G, et al. Ejekülat kültüründe Brucella melitensis üretilen epididimoorşitli bir bruselloz olgusu [Isolation of Brucella melitensis from ejaculate culture of a brucellosis patient with epididymoorchitis]. Mikrobiyol Bul. 2007;41(3):465-468.
2. 2. Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med. 2005;352(22):2325-2336. doi: 10.1056/NEJMra050570.
3. 3. Corbel MJ. Brucellosis: an overview. Emerg Infect Dis. 1997;3(2):213-221. doi: 10.3201/eid0302.970219.
4. 4. Arruza A, Pertusa C, Zabala JA, Llarena R. Brucelosis genital [Genital brucellosis]. Arch Esp Urol. 1990;43(6):673-674.
5. 5. Głowacka P, Żakowska D, Naylor K, Niemcewicz M, Bielawska-Drózd A. Brucella- Virulence Factors, Pathogenesis and Treatment. Pol J Microbiol. 2018;67(2):151-161. doi: 10.21307/pjm-2018-029.
6. 6. Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proc Natl Acad Sci U S A. 2002;99(24):15711-15716. doi: 10.1073/pnas.232454299.
7. 7. Bowman DD. Introduction to the alpha-proteobacteria: Wolbachia and Bartonella, Rickettsia, Brucella, Ehrlichia, and Anaplasma. Top Companion Anim Med. 2011;26(4):173-177. doi: 10.1053/j.tcam.2011.09.002.
8. 8. Scholz HC, Revilla-Fernández S, Dahouk SA, Hammerl JA, Zygmunt MS, Cloeckaert A, Koylass M, Whatmore AM, Blom J, Vergnaud G, Witte A, Aistleitner K, Hofer E. Brucella vulpis sp. nov., isolated from mandibular lymph nodes of red foxes (Vulpes vulpes). Int J Syst Evol Microbiol. 2016;66(5):2090-2098. doi: 10.1099/ijsem.0.000998.

9. 9. Byndloss MX, Tsolis RM. Brucella spp. Virulence Factors and Immunity. Annu Rev Anim Biosci. 2016;4:111-127. doi: 10.1146/annurev-animal-021815-111326.
10. 10. Bingöl A, Yücemen N, Meço O. Medically treated intraspinal "Brucella" granuloma. Surg Neurol. 1999;52(6):570-576. doi: 10.1016/s0090-3019(99)00110-x.
11. 11. Głowacka P, Żakowska D, Naylor K, Niemcewicz M, Bielawska-Drózd A. Brucella - Virulence Factors, Pathogenesis and Treatment. Pol J Microbiol. 2018;67(2):151-161. doi: 10.21307/pjm-2018-029.
12. 12. Christopher S, Umapathy BL, Ravikumar KL. Brucellosis: review on the recent trends in pathogenicity and laboratory diagnosis. J Lab Physicians. 2010;2(2):55-60. doi: 10.4103/0974-2727.72149.
13. 13. Galińska EM, Zagórski J. Brucellosis in humans--etiology, diagnostics, clinical forms. Ann Agric Environ Med. 2013;20(2):233-238.
14. 14. de Figueiredo P, Ficht TA, Rice-Ficht A, Rossetti CA, Adams LG. Pathogenesis and immunobiology of brucellosis: review of Brucella-host interactions. Am J Pathol. 2015;185(6):1505-1517. doi: 10.1016/j.ajpath.2015.03.003.
15. 15. Franco MP, Mulder M, Gilman RH, Smits HL. Human brucellosis. Lancet Infect Dis. 2007 ;7(12):775-786. doi: 10.1016/S1473-3099(07)70286-4.
16. 16. Solera J, Martínez-Alfaro E, Espinosa A, Castillejos ML, Geijo P, Rodríguez-Zapata M. Multivariate model for predicting relapse in human brucellosis. J Infect. 1998;36(1):85-92. doi: 10.1016/s0163-4453(98)93342-4.
17. 17. Byndloss MX, Tsolis RM. Brucella spp. Virulence Factors and Immunity. Annu Rev Anim Biosci. 2016;4:111-127. doi: 10.1146/annurev-animal-021815-111326.
18. 18. Rubach MP, Halliday JE, Cleaveland S, Crump JA. Brucellosis in low-income and middle-income countries. Curr Opin Infect Dis. 2013;26(5):404-412. doi: 10.1097/QCO.0b013e3283638104.
19. 19. Pappas G, Papadimitriou P, Akritidis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis. 2006;6(2):91-99. doi: 10.1016/S1473-3099(06)70382-6.
20. 20. Charypkhan D, Sultanov AA, Ivanov NP, Baramova SA, Taitubayev MK, Torgerson PR. Economic and health burden of brucellosis in Kazakhstan. Zoonoses Public Health. 2019;66(5):487-494. doi: 10.1111/zph.12582.
21. 21. Allen A, Breadon E, Byrne A, Mallon T, Skuce R, Groussaud P, et al. Molecular Epidemiology of Brucella abortus in Northern Ireland-1991 to 2012. PLoS One. 2015;10(9):e0136721. doi: 10.1371/journal.pone.0136721.
22. 22. Kayaaslan B, Bastug A, Aydin E, Akinci E, But A, Aslaner H, et al. A long-term survey of brucellosis: Is there any marker to predict the complicated cases? Infect Dis (Lond). 2016;48(3):215-221. doi: 10.3109/23744235.2015.1107187.
23. 23. Wise RI. Brucellosis in the United States past, present and future. JAMA. 1980; 244:2318-2322.
24. 24. Doganay M, Aygen B. Human brucellosis: An overview. Int J Infec Dis. 2003; 7:173-182.
25. 25. Dean AS, Crump L, Greter H, Hattendorf J, Schelling E, Zinsstag J. Clinical manifestations of human brucellosis: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2012;6(12):e1929. doi: 10.1371/journal. pntd.0001929.
26. 26. Young EJ. Brucella species. In: Mandell GL, Bennett JE, Dolin R (eds). Principles and Practice of Infectious Diseases. 7th ed. Philadelphia: Elsevier Churchill Livingstone 2010;2921-2925.
27. 27. Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O, et al. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis. 2010;14(6):e469-478. doi: 10.1016/j.ijid.2009.06.031.
28. 28. Balın ŞÖ, Tartar AS, Akbulut A. The predictive role of haematological parameters in the diagnosis of osteoarticular brucellosis. Afr Health Sci. 2018;18(4):988-994. doi: 10.4314/ahs.v18i4.19.
29. 29. Colmenero JD, Reguera JM, Martos F, Sánchez-De-Mora D, Delgado M, Causse M, et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore). 1996;75(4):195-211. doi: 10.1097/00005792-199607000-00003.
30. 30. Demirdal T, Sen P. Risk factors for focal involvement in brucellosis. Diagn Microbiol Infect Dis. 2020;97(1):115003. doi: 10.1016/j.diagmicrobio.2020.115003.
31. 31. Korkmaz N, Ölçücü MT, Ateş F. Comparision of Brucella and Non-Brucella Epididymo-orchitis. J Coll Physicians Surg Pak 2020; 30(04):403-406. doi: https://doi.org/10.29271/jcpsp.2020.04.403.
32. 32. Erdem H, Elaldi N, Ak O, Gulsun S, Tekin R, Ulug M, et al. Genitourinary brucellosis: results of a multicentric study. Clin Microbiol Infect. 2014;20(11):O847-853. doi: 10.1111/1469-0691.12680.
33. 33. Meltzer E, Sidi Y, Smolen G, Banai M, Bardenstein S, Schwartz E. Sexually transmitted brucellosis in humans. Clin Infect Dis. 2010;51(2):e12-15. doi: 10.1086/653608.
34. 34. Prostatitis. Turek PJ. Medscape. Avaliable from: https://emedicine.medscape.com/article/785418-overview.
35. 35. Krieger JN, Nyberg L Jr, Nickel JC. NIH consensus definition and classification of prostatitis. JAMA. 1999;282(3):236-237. doi: 10.1001/jama.282.3.236.
36. 36. Krieger JN, Lee SW, Jeon J, Cheah PY, Liong ML, Riley DE. Epidemiology of prostatitis. Int J Antimicrob Agents. 2008;31 Suppl 1(Suppl 1):S85-90. doi: 10.1016/j.ijantimicag.2007.08.028.
37. 37. Stamey T. Urinary tract infections in males. In: Stamey T, Editor. Pathogenesis and treatment of urinary tract infections. Baltimore: Williams and Wilkins.1980;pp.342-429.
38. 38. Roberts RO, Lieber MM, Rhodes T, Girman CJ, Bostwick DG, Jacobsen SJ. Prevalence of a physician-assigned diagnosis of prostatitis: the Olmsted County Study of Urinary Symptoms and Health Status Among Men. Urology. 1998; 51:578–584.
39. 39. Ulleryd P. Febrile urinary tract infection in men. Int J Antimicrob Agents. 2003;22 Suppl 2:89-93. doi: 10.1016/s0924-8579(03)00228-0.
40. 40. Collins MM, Stafford RS, O'Leary MP, Barry MJ. How common is prostatitis? A national survey of physician visits. J Urol. 1998;159(4):1224-1228.
41. 41. Haki Yuksel O, Urkmez A, Verit A. The role of Cajal cells in chronic prostatitis. Arch Ital Urol Androl. 2016;88(2):133-135. doi: 10.4081/aiua.2016.2.133.
42. 42. Coker TJ, Dierfeldt DM. Acute Bacterial Prostatitis: Diagnosis and Management. Am Fam Physician. 2016;93(2):114-120.
43. 43. Schneider H, Ludwig M, Hossain HM, et al. The 2001 Giessen Cohort Study on patients with prostatitis syndrome: an evaluation of inflammatory status and search for microorganisms 10 years after a first analysis. Andrologia 2003; 35:258–262.
44. 44. Meares EM Jr. Acute and chronic prostatitis: diagnosis and treatment. Infect Dis Clin North Am. 1987; 1:855–873.
45. 45. Millan-Rodriguez F, Palou J, Bujons-Tur A, Musquera-Felip M, Sevilla-Cecilia C, Serrallach-Orejas M, et al. Acute bacterial prostatitis: two different sub-categories according to a previous manipulation of the lower urinary tract. World J Urol. 2006; 24:45–50.
46. 46. Gill BC, Shoskes DA. Bacterial prostatitis. Curr Opin Infect Dis. 2016;29(1):86-91. doi: 10.1097/QCO.0000000000000222.
47. 47. Shang Y, Liu C, Cui D, Han G, Yi S. The effect of chronic bacterial prostatitis on semen quality in adult men: a meta-analysis of case-control studies. Sci Rep. 2014;4:7233. doi: 10.1038/srep07233.
48. 48. Cai T, Pisano F, Magri V, Verze P, Mondaini N, D'Elia C, et al. Chlamydia trachomatis infection is related to premature ejaculation in chronic prostatitis patients: results from a cross-sectional study. J Sex Med. 2014;11(12):3085-3092. doi: 10.1111/jsm.12699.
49. 49. Snow DC, Shoskes DA. Pharmacotherapy of prostatitis. Expert Opin Pharmacother. 2010;11(14):2319-2330. doi: 10.1517/14656566.2010.495946.
50. 50. Lan S, Guo Z, He Y, Liu W, Guo H. Brucella prostatic abscess: a retrospective study of eight cases and a literature review. J Int Med Res. 2021;49(9):3000605211027442. doi: 10.1177/03000605211027442.
51. 51. Ben Arab N, Maâloul I, Bouhlel A, Marrekchi C, Khemekhem Hammami B, Mhiri N, et al. Abcès prostatique à Brucella [Brucella prostatic abscess]. Med Mal Infect. 2008 Apr;38(4):235-236. doi: 10.1016/j.medmal.2008.01.003.
52. 52. Dakdouki GK, Al Awar GN. Brucella prostatic abscess: first case report. Scand J Infect Dis. 2005;37(9):692-694. doi: 10.1080/00365540410021162.
53. 53. Alenazi AH, Alfhaidi FM, Aljumaah AAS, Alenzi MJ, AlOtaibi MM. A rare case of prostatic abscess caused by Brucella organisms: First report in Saudi Arabia. Urol Ann. 2018;10(1):106-107. doi: 10.4103/UA.UA_67_17.
54. 54. Mangalgi SS, Sajjan AG, Mohite ST, Gajul S. Brucellosis in Occupationally Exposed Groups. J Clin Diagn Res. 20162;10(4): DC24-27. doi: 10.7860/JCDR/2016/15276.7673.
55. 55. Zhou Y, Xie S, Zheng R, Dai Q, Xu Z, Zuo W, et al. Brucellar reproductive system injury: A retrospective study of 22 cases and review of the literature. J Int Med Res. 2020;48(6):300060520924548. doi: 10.1177/0300060520924548.
56. 56. Bosilkovski M, Kamiloski V, Miskova S, Balalovski D, Kotevska V, Petrovski M. Testicular infection in brucellosis: Report of 34 cases. J Microbiol Immunol Infect. 2018;51(1):82-87. doi: 10.1016/j.jmii.2016.02.004.
57. 57. Aksoy F, Aksoy HZ, Sözen EE, Yilmaz G, Köksal I. Prostat karsinomu ile karişan bir Brucella prostatiti olgusu [A case of Brucella prostatitis misdiagnosed as prostate carcinoma]. Mikrobiyol Bul. 2009;43(3):493-497.