Age and Sex-Related Changes in Corpus Callosum Morphometry: A Magnetic Resonance Imaging Study
Abstract
Aim: This study evaluates the morphometric data of the corpus callosum (CC) in a healthy Turkish population and aims to provide a benchmark to help identify relevant pathologic conditions. Materials and Methods: The study designed retrospectively has been conducted by using brain Magnetic Resonance images (MRI’s) of 360 individuals between the ages of 25-55 years who were admitted to the clinic with headache complaints. The anteroposterior diameter of the CC (CCAPD), the genu thickness of the CC (CCGT), the splenium thickness of the CC (CCST), the body thickness of the CC (CCBT), the CC height (CCH), the distance between the anterior end of the CC and the vertex (DAV), the distance between the posterior end of the CC and the vertex (DPV), the distance between anterior end, inner end, and vertex of the CC (DAIV), the distance between posterior end, inner end, and vertex of the CC (DPIV), the angle between DAV-DPV (AI), and the angle between DAIV-DPIV (AII) variables were measured in the study. Statistics were performed by RStudio (2023.12.1) program. Results: In the analysis of the CC sections, the difference between the groups classified according to age was found to be statistically significant. Additionally, CCBT, DAV and DAIV variables in the 1st group, CCAPD, CCGT, CCBT and DAV variables in the 2nd group and DAV variables in the 3rd group show sex-related changes. Conclusion: The study results are in accordance with the extant literature, which emphasises that gender and age group are significant factors in the morphology of CC segments.
Keywords
References
- Fabri M, Polonara G, Mascioli G. Topographical organization of human corpus callosum: An fMRI mapping study. Brain Research. 2011;99-111.
- Loprinzi PD, Harper J, Ikuta T. The effects of aerobic exercise on corpus callosum integrity: systematic review. The Physician and Sportsmedicine. 2020;48(4):400–406. https://doi.org/10.1080/00913847.2020.1758545
- Wahl M, Lauterbach-Soon B, Hattingen E, et al. Human Motor Corpus Callosum:Topography, Somatotopy, and Link between Microstructure and Function. J. Neurosci. 2007;27(45):12132–12138. DOI:10.1523/JNEUROSCI.2320-07.2007
- Garel C, Cont I, Alberti C, et al. Biometry of the Corpus Callosum in Children: MR Imaging Reference Data. AJNR Am J Neuroradiol. 2011;32:1436–43.
- Nosarti C, Rushe MT, Woodruff PWR, et al. Corpus callosum size and very preterm birth: relationship to neuropsychological outcome. Brain. 2004;127:2080–2089. DOI: 10.1093/brain/awh230
- Teicher MH, Dumont NL, Ito Y, et al. Childhood Neglect Is Associated with Reduced Corpus Callosum Area. Biol Psychiatry. 2004;56:80–85. doi: 10.1016/j.biopsych.2004.03.016
- Al-Hadidi MT, Kalbouneh HM, Ramzy A, et al. Sex and age-related differences in the morphometry of corpus callosum: MRI study. Eur J Anat. 2021;25(1): 15-24.
- Allouh MZ, Barbarawi M, Ali HA, et al. Morphometric Analysis of the Corpus Callosum According to Age and Sex in Middle Eastern Arabs: Racial Comparisons and Clinical Correlations to Autism Spectrum Disorder. Front Syst Neurosci. 2020;23:14:30. doi: 10.3389/fnsys.2020.00030
- Arda KN, Akay S. The Relationship between Corpus Callosum Morphometric Measurements and Age/Sex Characteristics: A Comprehensive MR Imaging Study. Journal of Clinical Imaging Science. 2019;9(33). DOI 10.25259/JCIS-13-2019
- Shin YW, Kim DJ, Ha TH, et al. Sex diferences in the human corpus callosum: difusion tensor imaging study. Neuroreport. 2005;16(8):795-8. doi: 10.1097/00001756-200505310-00003.