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RESEARCH FOR THE EFFECTS OF CRONIC INORGANIC ARSENIC INTOXICATION ON CERTAIN BIOCHEMICAL AND PHYSIOLOGICAL PARAMETERS

Year 2011, Issue: 026, 69 - 76, 15.12.2011

Abstract

In this study,
it was aimed to research the changes in some biochemical parameters and blood
pressure values of those exposed to inorganic arsenic by drinking water
involving high level of arsenic for a long time. Forming two groups- the
control group and the one composed of those exposed to chronic arsenic, the
values were compared between the groups. By taking venous blood samples from
the subjects, blood glucose, triglyceride and total cholesterol levels were
determined in their serums. Also, by taking their blood pressure, their
diastolic and systolic blood pressure values were determined. It was found that
those exposed to chronic arsenic had higher blood glucose, triglyceride, total
cholesterol levels and blood pressure values than the control group. The mean
values of those exposed to chronic arsenic and the control group were as
follows respectively: blood glucose levels 139.90 ± 36.22 mg/dl vs 96.86 ± 21.90
mg/dl, triglyceride levels 189.28 ± 43.76 mg/dl vs 131.33 ± 35.14 mg/dl, total
cholesterol levels 156.34 ± 29,61 mg/dl vs 118.53 ± 46.15 mg/dl, diastolic blood
pressure 81.92 ± 10.59 mm Hg
vs 71.50 ± 7.27 mm Hg, and
systolic blood pressure 138.46 ± 21.59 mm
Hg vs 114.50 ± 13.07 mm Hg. As
a result of statistical analysis, the values were determined to be significant
(p<0.001).

 





Consequently, it
can be said that a long term exposure to high amount of inorganic arsenic in
drinking water have adverse effects on the biochemical parameters in humans and
that the risk of different ailments in these subjects may increase depending on
the oxidative stress caused by arsenic.

References

  • [1] M. Çöl, C. Çöl, A. Soran, B.S. Sayli, S. Öztürk, ‘‘Arsenic-related Bowen’s disease, palmerkeratosis, and skin cancer’’, Environmental Health Perspectives, 107, (8), 687-689 (1999).
  • [2] World Health Organization, ‘‘Air quality guidelines for Europe’’, WHO European Series No 23, Copenhagen, 173, (1987)
  • [3] World Health Organization, ‘‘International Agency for research on cancer report of the advisory group to plan’’ Volume 100: A Review of human carcinogens. Lyon, (2006).
  • [4] D.N. Mazumder, J. Das Gupta, A.K. Chakraborty, A. Chatterjee, D. Das, D. Chakraborty, ‘‘Environmental pollution and chronic arsenicosis in South Calcutta’’, 70, (4), 481-485 (1992).
  • [5] J.M. Stellman, ‘‘Encyclopaedia of Occupational Health and Safety’’, Fourth Edition, International Labour Organisation, Switzerland (1998).
  • [6] C. Abernathy, ‘‘United Nations synthesis report on arsenic in drinking water, chapter 3: exposure and health effects’’ World Health Organization, Genova (2001).
  • [7] K.G. Brown, G.L. Ross, ‘‘Arsenic, Drinking Water, and Health’’, Regul Toxicol Pharmacol, 36, (2), 162-174. (2002).
  • [8] V.M. Rodriguez, M.E. Jiménez-Capdeville, M. Giordano, ‘‘The effects of arsenic exposure on the nervous system’’, Toxicol Lett., 145, 1-18, (2003).
  • [9] P.B. Tchounwou, A.K. Patlolla, J.A. Centeno, ‘‘Carcinogenic and systemic health effects associated with arsenic exposure’’, Toxicol Pathol, 31, (6), 575-588 (2003).
  • [10] M. Valko, C.J. Valkoa, J. Moncol, M. Izakovica and M. Mazura, ‘‘Free radicals, metals and antioxidants in oxidative stress-induced cancer’’, Chem Biol Interact, 160, (1) 1-40 (2006).
  • [11] C. Ferreccio, C. Gonzalez, V. Milosavjlevic, G. Marshall, A.M. Sancha, A.H. Smith ‘‘Lung cancer and arsenic concentrations in drinking water in Chile’’, Epidemiology, 1, 673-679 (2000).
  • [12] H.Y. Chiou, S.T. Chiou, Y.H. Hsu, Y.L. Chou, C.H. Tseng, M.L. Wei, C.J. Chen, ‘‘Incidence of transitional cell carcinoma and arsenic in drinking water: a follow-up study of 8,102 residents in an arseniasis-endemic area in northeastern Taiwan’’, Am. J. Epidemiol, 153, 411-418 (2001).
  • [13] S.B. Tucker, F.X. Li, R. Wilson, D.M. Byrd, S. Lai, Y. Tong, L. Loo, ‘‘Relationship between consumption of arsenic-contaminated well water and skin disorders’’, in Huhhot Inner Mongolıa (A final report from the University of Texas), UBA (2001).
  • [14] W.P. Tseng, ‘‘Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic’’, Environ Health Perspect, 19, 109-119 (1977).
  • [15] S. Ahamed, M.K. Sengupta, A. Mukherjee, M.A. Hossain, B. Das, B. Nayak, A. Pal, S.C. Mukherjee, S. Pati, R.N. Dutta, G. Chatterjee, R. Srivastava, D. Chakraborti, ‘‘Arsenic groundwater contamination and its health effects in the state of Uttar Pradesh (UP) in Upper and Middle Ganga Plain, India: A Severe Danger’’ Sci.Total Env., 1-13 (2006).
  • [16] M. Ali, S.A. Tarafdar, ‘‘Arsenic in drinking water and in scalp hair by EDXRF: A Major recent health hazard in bangladesh’’, J. Radio. Nuc. Chem., 256, 297-305 (2003).
  • [17] D.D. Caceres, P. Pino, N. Montesinos, E. Atalah, H. Amigo, D. Loomis, ‘‘Exposure to ınorganic arsenic in drinking water and total urinary arsenic concentration in a Chilean Population’’, Env. Res., 98, 151-159 (2005).
  • [18] D. Chakraborti, S.C. Mukherjee, S. Pati, M.K. Sengupta, M.M. Rahman, U.K. Chowdhury, D. Lodh, C.R. Chanda, A.K. Chakraborti, G.K. Basu, ‘‘Arsenic groundwater contamination in middle Ganga Plain, Bihar, India: A Future Danger?’’, Env. Health Pers., 111, 1194-1201 (2003).
  • [19] O.S. Ehrenstein, D.N.G. Mazumder, Y. Yuan, S. Samanta, J. Balmes, A. Sil, N. Ghosh, M. Hira-Smith, R. Haque, R. Purushothamam, S. Lahiri, S. Das, A.H. Smith, ‘‘Decrements in lung function related to arsenic in drinking water in West Bengal, India’’, Am. J. Epidem., 162, 533-541 (2005).
  • [20] A. Kelepertsis, D. Alexakis, K. Skordas, ‘‘Arsenic, antimony and other toxic elements in the drinking water of eastern thessaly in greece and ıts possible effects on human health’’, Env. Geol., 50, 76-84 (2006).
  • [21] S.C. Mukherje, M.M. Rahman, U.K. Chowdhury, M.K. Sengupta, D. Lodh, C.R. Chanda, K.C. Saha, D. Chakraborti, ‘‘Neuropathy in arsenic toxicity from groundwater arsenic contamination in West Bengal, India’’, J. Env. Sci. Health. 1, 165-183 (2003).
  • [22] G. Mazumder, ‘‘Chronic Arsenic toxicity: clinical features, epidemiology, and Treatment: Experience in West Bengal’’ J. Env. Sci. Health, 1, 141-163 (2003).
  • [23] M.M. Rahman, M.K. Sengupta, S. Ahamed, U.K. Chowdhury, A. Hossain, B. Das, D. Lodh, K.C. Saha, S. Pati, I. Kaies, A.K. Barua, D. Chakraborti, ‘‘The magnitude of arsenic contamination in groundwater and its health effects to the ınhabitants of the jalangi-one of the 85 arsenic affected blocks in West Bengal, India’’ Sci. Total Env., 338, 189-200 (2005).
  • [24] Y. Xia, J. Liu, ‘‘An overview on chronic arsenism Via Drinking Water in PR China’’, Toxicology, 198, 25-29 (2004).
  • [25] Sağlık Bakanlığı Temel Sağlık Hizmetleri Genel Müdürlüğü. İnsani Tüketim Amaçlı Sular Hk.Yönetmelik 17 Şubat (2005).
  • [26] C. Hopenhayn, C. Ferrecio, S. R. Browning, B. Huang, C. Peralta, H. Gibb, “Arsenic expousure from drinking water and birth weight”, Epidemiology, 14, (5), 593-602 (2003).
  • [27] H.R. Guo, Y.C. Tseng, ‘‘Arsenic in drinking water and bladder cancer: Comparison between studies based on cancer registry and death certificates’’, Environ Geochem Health, 22, 83-91, (2000).
  • [28] O. Yılmaz, K. Ekici, ‘‘Van Yöresinde İçme Sularında Arsenikle Kirlenme Düzeyleri’’ Yüzüncü Yıl Üniversitesi Veterinerlik Fakültesi Dergisi, 15, (1-2), 47-51 (2005).
  • [29] M. Doğan, A.U. Doğan, C. Çelebi, Y.I. Barış, ‘‘Geogenic Arsenic and the Dose response of Skin Lesions in the Emet Region of Kütahya, Turkey’’, Indoor and Built Environment, 14, (6), 533-536 (2005).
  • [30] S. Sardaş, ‘‘Risk Assessment in Arsenic Exposure’’, Tıbbi Jeoloji Çalıştayı, 138-144 (2009).
  • [31] J.A. Izquierdo-Vega, C.A. Soto, L.C. Sanchez-Peña, A. De Vizcaya-Ruiz , L.M. Del Razo , ‘‘Diabetogenic effects and pancreatic oxidative damage in rats subchronically exposed to arsenite’’, Toxicol Lett, 160, (2), 135-142 (2006).
  • [32] U. Biswas, S. Sarkar, M.K. Bhowmik, A.K. Samanta, S. Biswas ‘‘Chronic toxicity of arsenic in goats: clinicobiochemical changes, pathomorphology and tissue residues’’, Small Rumin Res, 38,(3), 229-235 (2000).
  • [33] C.H. Tseng, ‘‘The potential biological mechanisms of arsenic-induced diabetes mellitus’’, Toxicol Appl Pharmacol, 197, (2), 67-83 (2004).
  • [34] S.M. Tsai, T.N. Wang, Y.C. Ko, ‘‘Mortality for certain diseases in areas with high levels of arsenic in drinking water’’, Arch Environ Health, 54, (3), 186-193 (1999).
  • [35] M. Rahman, O. Axelson, ‘‘Diabetes mellitus and arsenic exposure: a second look at case-control data from a Swedish copper smelter’’, Occup Environ Med., 52, (11), 773-774 (1995).
  • [36] M. Rahman, G. Wingren, O. Axelson, ‘‘Diabetes mellitus among Swedish art glass workers--an effect of arsenic exposure?’’, Scand J Work Environ Health, 22, (2), 146-149 (1996).
  • [37] S.L. Wang, W.F. Li, C.J. Chen, Y.L. Huang, J.W. Chen, K.H. Chang, L.Y. Tsai, K.M. Chou, ‘‘Hypertension incidence after tap-water implementation: A 13-year follow-up study in the arseniasis-endemic area of southwestern Taiwan’’, Sci Total Environ, 409,(21), 4528-4535(2011).
  • [38] İ. Akkuş, ‘‘Serbest radikalller ve fizyopatolojik etkileri’’, Mimoza yayınları, 96 (1995).

İNSANDAKİ KRONİK İNORGANİK ARSENİK İNTOKSİKASYONUNUN BAZI BİYOKİMYASAL VE FİZYOLOJİK PARAMETRELERE ETKİLERİNİN ARAŞTIRILMASI

Year 2011, Issue: 026, 69 - 76, 15.12.2011

Abstract

Bu
çalışmada uzun süre yüksek oranda arsenikli içme suyu ile inorganik arseniğe
maruz kalan kişilerde bazı biyokimyasal parametre ve kan basınç değerlerinde
meydana gelen değişimlerin araştırılması amaçlandı. Çalışmada kronik arseniğe
maruz kalan kişiler ve kontrol grubu olmak üzere iki grup oluşturularak
değerler gruplar arası kıyaslandı. Çalışmaya katılan kişilerden venöz kan
alınarak, serumlarında kan glukozu, trigliserit ve total kolesterol seviyeleri
belirlendi. Ayrıca bu kişilerin tansiyonu ölçülerek diastolik ve sistolik kan
basınç değerleri tespit edildi. Kronik arseniğe maruz kalanlarda kontrol
grubuna göre kan glukozu, trigliserit ve total kolesterol seviyeleri ile kan
basınç değerlerinin yüksek olduğu tespit edildi. Kronik olarak arseniğe maruz
kalan kişiler ile kontrol grubu değerleri ortalamaları sırasıyla kan glukoz
düzeyleri 139,90 ± 36,22 mg/dl vs 96,86 ± 21,90 mg/dl, trigliserit düzeyleri
189,28 ± 43,76 mg/dl vs 131,33 ± 35,14 mg/dl, total kolestrol düzeyleri 156,34 ±
29,61 mg/dl vs 118,53 ± 46,15 mg/dl, diastolik kan basıncı 81,92 ± 10,59 mm Hg vs 71,50 ± 7,27 mm Hg, sistolik kan basıncı 138,46 ± 21,59 mm Hg vs 114,50 ± 13,07 mm Hg olarak tespit edildi. Yapılan
istatistiksel analiz sonucunda değerlerin anlamlı (p<0,001) olduğu tespit
edildi. 
Sonuç
olarak uzun süre içme suyundaki yüksek orandaki inorganik arseniğin insanlarda
biyokimyasal parametreleri olumsuz yönde etkilediği ve arseniğin oluşturduğu
oksidatif strese bağlı olarak bu kişilerde farklı hastalıkların oluşma riskini
arttırabileceğini söyleyebiliriz.

References

  • [1] M. Çöl, C. Çöl, A. Soran, B.S. Sayli, S. Öztürk, ‘‘Arsenic-related Bowen’s disease, palmerkeratosis, and skin cancer’’, Environmental Health Perspectives, 107, (8), 687-689 (1999).
  • [2] World Health Organization, ‘‘Air quality guidelines for Europe’’, WHO European Series No 23, Copenhagen, 173, (1987)
  • [3] World Health Organization, ‘‘International Agency for research on cancer report of the advisory group to plan’’ Volume 100: A Review of human carcinogens. Lyon, (2006).
  • [4] D.N. Mazumder, J. Das Gupta, A.K. Chakraborty, A. Chatterjee, D. Das, D. Chakraborty, ‘‘Environmental pollution and chronic arsenicosis in South Calcutta’’, 70, (4), 481-485 (1992).
  • [5] J.M. Stellman, ‘‘Encyclopaedia of Occupational Health and Safety’’, Fourth Edition, International Labour Organisation, Switzerland (1998).
  • [6] C. Abernathy, ‘‘United Nations synthesis report on arsenic in drinking water, chapter 3: exposure and health effects’’ World Health Organization, Genova (2001).
  • [7] K.G. Brown, G.L. Ross, ‘‘Arsenic, Drinking Water, and Health’’, Regul Toxicol Pharmacol, 36, (2), 162-174. (2002).
  • [8] V.M. Rodriguez, M.E. Jiménez-Capdeville, M. Giordano, ‘‘The effects of arsenic exposure on the nervous system’’, Toxicol Lett., 145, 1-18, (2003).
  • [9] P.B. Tchounwou, A.K. Patlolla, J.A. Centeno, ‘‘Carcinogenic and systemic health effects associated with arsenic exposure’’, Toxicol Pathol, 31, (6), 575-588 (2003).
  • [10] M. Valko, C.J. Valkoa, J. Moncol, M. Izakovica and M. Mazura, ‘‘Free radicals, metals and antioxidants in oxidative stress-induced cancer’’, Chem Biol Interact, 160, (1) 1-40 (2006).
  • [11] C. Ferreccio, C. Gonzalez, V. Milosavjlevic, G. Marshall, A.M. Sancha, A.H. Smith ‘‘Lung cancer and arsenic concentrations in drinking water in Chile’’, Epidemiology, 1, 673-679 (2000).
  • [12] H.Y. Chiou, S.T. Chiou, Y.H. Hsu, Y.L. Chou, C.H. Tseng, M.L. Wei, C.J. Chen, ‘‘Incidence of transitional cell carcinoma and arsenic in drinking water: a follow-up study of 8,102 residents in an arseniasis-endemic area in northeastern Taiwan’’, Am. J. Epidemiol, 153, 411-418 (2001).
  • [13] S.B. Tucker, F.X. Li, R. Wilson, D.M. Byrd, S. Lai, Y. Tong, L. Loo, ‘‘Relationship between consumption of arsenic-contaminated well water and skin disorders’’, in Huhhot Inner Mongolıa (A final report from the University of Texas), UBA (2001).
  • [14] W.P. Tseng, ‘‘Effects and dose-response relationships of skin cancer and blackfoot disease with arsenic’’, Environ Health Perspect, 19, 109-119 (1977).
  • [15] S. Ahamed, M.K. Sengupta, A. Mukherjee, M.A. Hossain, B. Das, B. Nayak, A. Pal, S.C. Mukherjee, S. Pati, R.N. Dutta, G. Chatterjee, R. Srivastava, D. Chakraborti, ‘‘Arsenic groundwater contamination and its health effects in the state of Uttar Pradesh (UP) in Upper and Middle Ganga Plain, India: A Severe Danger’’ Sci.Total Env., 1-13 (2006).
  • [16] M. Ali, S.A. Tarafdar, ‘‘Arsenic in drinking water and in scalp hair by EDXRF: A Major recent health hazard in bangladesh’’, J. Radio. Nuc. Chem., 256, 297-305 (2003).
  • [17] D.D. Caceres, P. Pino, N. Montesinos, E. Atalah, H. Amigo, D. Loomis, ‘‘Exposure to ınorganic arsenic in drinking water and total urinary arsenic concentration in a Chilean Population’’, Env. Res., 98, 151-159 (2005).
  • [18] D. Chakraborti, S.C. Mukherjee, S. Pati, M.K. Sengupta, M.M. Rahman, U.K. Chowdhury, D. Lodh, C.R. Chanda, A.K. Chakraborti, G.K. Basu, ‘‘Arsenic groundwater contamination in middle Ganga Plain, Bihar, India: A Future Danger?’’, Env. Health Pers., 111, 1194-1201 (2003).
  • [19] O.S. Ehrenstein, D.N.G. Mazumder, Y. Yuan, S. Samanta, J. Balmes, A. Sil, N. Ghosh, M. Hira-Smith, R. Haque, R. Purushothamam, S. Lahiri, S. Das, A.H. Smith, ‘‘Decrements in lung function related to arsenic in drinking water in West Bengal, India’’, Am. J. Epidem., 162, 533-541 (2005).
  • [20] A. Kelepertsis, D. Alexakis, K. Skordas, ‘‘Arsenic, antimony and other toxic elements in the drinking water of eastern thessaly in greece and ıts possible effects on human health’’, Env. Geol., 50, 76-84 (2006).
  • [21] S.C. Mukherje, M.M. Rahman, U.K. Chowdhury, M.K. Sengupta, D. Lodh, C.R. Chanda, K.C. Saha, D. Chakraborti, ‘‘Neuropathy in arsenic toxicity from groundwater arsenic contamination in West Bengal, India’’, J. Env. Sci. Health. 1, 165-183 (2003).
  • [22] G. Mazumder, ‘‘Chronic Arsenic toxicity: clinical features, epidemiology, and Treatment: Experience in West Bengal’’ J. Env. Sci. Health, 1, 141-163 (2003).
  • [23] M.M. Rahman, M.K. Sengupta, S. Ahamed, U.K. Chowdhury, A. Hossain, B. Das, D. Lodh, K.C. Saha, S. Pati, I. Kaies, A.K. Barua, D. Chakraborti, ‘‘The magnitude of arsenic contamination in groundwater and its health effects to the ınhabitants of the jalangi-one of the 85 arsenic affected blocks in West Bengal, India’’ Sci. Total Env., 338, 189-200 (2005).
  • [24] Y. Xia, J. Liu, ‘‘An overview on chronic arsenism Via Drinking Water in PR China’’, Toxicology, 198, 25-29 (2004).
  • [25] Sağlık Bakanlığı Temel Sağlık Hizmetleri Genel Müdürlüğü. İnsani Tüketim Amaçlı Sular Hk.Yönetmelik 17 Şubat (2005).
  • [26] C. Hopenhayn, C. Ferrecio, S. R. Browning, B. Huang, C. Peralta, H. Gibb, “Arsenic expousure from drinking water and birth weight”, Epidemiology, 14, (5), 593-602 (2003).
  • [27] H.R. Guo, Y.C. Tseng, ‘‘Arsenic in drinking water and bladder cancer: Comparison between studies based on cancer registry and death certificates’’, Environ Geochem Health, 22, 83-91, (2000).
  • [28] O. Yılmaz, K. Ekici, ‘‘Van Yöresinde İçme Sularında Arsenikle Kirlenme Düzeyleri’’ Yüzüncü Yıl Üniversitesi Veterinerlik Fakültesi Dergisi, 15, (1-2), 47-51 (2005).
  • [29] M. Doğan, A.U. Doğan, C. Çelebi, Y.I. Barış, ‘‘Geogenic Arsenic and the Dose response of Skin Lesions in the Emet Region of Kütahya, Turkey’’, Indoor and Built Environment, 14, (6), 533-536 (2005).
  • [30] S. Sardaş, ‘‘Risk Assessment in Arsenic Exposure’’, Tıbbi Jeoloji Çalıştayı, 138-144 (2009).
  • [31] J.A. Izquierdo-Vega, C.A. Soto, L.C. Sanchez-Peña, A. De Vizcaya-Ruiz , L.M. Del Razo , ‘‘Diabetogenic effects and pancreatic oxidative damage in rats subchronically exposed to arsenite’’, Toxicol Lett, 160, (2), 135-142 (2006).
  • [32] U. Biswas, S. Sarkar, M.K. Bhowmik, A.K. Samanta, S. Biswas ‘‘Chronic toxicity of arsenic in goats: clinicobiochemical changes, pathomorphology and tissue residues’’, Small Rumin Res, 38,(3), 229-235 (2000).
  • [33] C.H. Tseng, ‘‘The potential biological mechanisms of arsenic-induced diabetes mellitus’’, Toxicol Appl Pharmacol, 197, (2), 67-83 (2004).
  • [34] S.M. Tsai, T.N. Wang, Y.C. Ko, ‘‘Mortality for certain diseases in areas with high levels of arsenic in drinking water’’, Arch Environ Health, 54, (3), 186-193 (1999).
  • [35] M. Rahman, O. Axelson, ‘‘Diabetes mellitus and arsenic exposure: a second look at case-control data from a Swedish copper smelter’’, Occup Environ Med., 52, (11), 773-774 (1995).
  • [36] M. Rahman, G. Wingren, O. Axelson, ‘‘Diabetes mellitus among Swedish art glass workers--an effect of arsenic exposure?’’, Scand J Work Environ Health, 22, (2), 146-149 (1996).
  • [37] S.L. Wang, W.F. Li, C.J. Chen, Y.L. Huang, J.W. Chen, K.H. Chang, L.Y. Tsai, K.M. Chou, ‘‘Hypertension incidence after tap-water implementation: A 13-year follow-up study in the arseniasis-endemic area of southwestern Taiwan’’, Sci Total Environ, 409,(21), 4528-4535(2011).
  • [38] İ. Akkuş, ‘‘Serbest radikalller ve fizyopatolojik etkileri’’, Mimoza yayınları, 96 (1995).
There are 38 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Articles
Authors

Sayit Altıkat This is me

Halil İsa Kuru This is me

Publication Date December 15, 2011
Published in Issue Year 2011 Issue: 026

Cite

APA Altıkat, S., & Kuru, H. İ. (2011). RESEARCH FOR THE EFFECTS OF CRONIC INORGANIC ARSENIC INTOXICATION ON CERTAIN BIOCHEMICAL AND PHYSIOLOGICAL PARAMETERS. Journal of Science and Technology of Dumlupınar University(026), 69-76.

HAZİRAN 2020'den itibaren Journal of Scientific Reports-A adı altında ingilizce olarak yayın hayatına devam edecektir.