RESEARCH FOR THE EFFECTS OF CRONIC INORGANIC ARSENIC INTOXICATION ON CERTAIN BIOCHEMICAL AND PHYSIOLOGICAL PARAMETERS

Year 2011, Issue: 026, 69 - 76, 15.12.2011

Sayit Altıkat Halil İsa Kuru

Abstract

In this study,
it was aimed to research the changes in some biochemical parameters and blood
pressure values of those exposed to inorganic arsenic by drinking water
involving high level of arsenic for a long time. Forming two groups- the
control group and the one composed of those exposed to chronic arsenic, the
values were compared between the groups. By taking venous blood samples from
the subjects, blood glucose, triglyceride and total cholesterol levels were
determined in their serums. Also, by taking their blood pressure, their
diastolic and systolic blood pressure values were determined. It was found that
those exposed to chronic arsenic had higher blood glucose, triglyceride, total
cholesterol levels and blood pressure values than the control group. The mean
values of those exposed to chronic arsenic and the control group were as
follows respectively: blood glucose levels 139.90 ± 36.22 mg/dl vs 96.86 ± 21.90
mg/dl, triglyceride levels 189.28 ± 43.76 mg/dl vs 131.33 ± 35.14 mg/dl, total
cholesterol levels 156.34 ± 29,61 mg/dl vs 118.53 ± 46.15 mg/dl, diastolic blood
pressure 81.92 ± 10.59 mm Hg
vs 71.50 ± 7.27 mm Hg, and
systolic blood pressure 138.46 ± 21.59 mm
Hg vs 114.50 ± 13.07 mm Hg. As
a result of statistical analysis, the values were determined to be significant
(p<0.001).

 

Consequently, it
can be said that a long term exposure to high amount of inorganic arsenic in
drinking water have adverse effects on the biochemical parameters in humans and
that the risk of different ailments in these subjects may increase depending on
the oxidative stress caused by arsenic.

Keywords

Arsenic, Intoxication, Biochemical parameters, Blood pressure

İNSANDAKİ KRONİK İNORGANİK ARSENİK İNTOKSİKASYONUNUN BAZI BİYOKİMYASAL VE FİZYOLOJİK PARAMETRELERE ETKİLERİNİN ARAŞTIRILMASI

Abstract

Bu
çalışmada uzun süre yüksek oranda arsenikli içme suyu ile inorganik arseniğe
maruz kalan kişilerde bazı biyokimyasal parametre ve kan basınç değerlerinde
meydana gelen değişimlerin araştırılması amaçlandı. Çalışmada kronik arseniğe
maruz kalan kişiler ve kontrol grubu olmak üzere iki grup oluşturularak
değerler gruplar arası kıyaslandı. Çalışmaya katılan kişilerden venöz kan
alınarak, serumlarında kan glukozu, trigliserit ve total kolesterol seviyeleri
belirlendi. Ayrıca bu kişilerin tansiyonu ölçülerek diastolik ve sistolik kan
basınç değerleri tespit edildi. Kronik arseniğe maruz kalanlarda kontrol
grubuna göre kan glukozu, trigliserit ve total kolesterol seviyeleri ile kan
basınç değerlerinin yüksek olduğu tespit edildi. Kronik olarak arseniğe maruz
kalan kişiler ile kontrol grubu değerleri ortalamaları sırasıyla kan glukoz
düzeyleri 139,90 ± 36,22 mg/dl vs 96,86 ± 21,90 mg/dl, trigliserit düzeyleri
189,28 ± 43,76 mg/dl vs 131,33 ± 35,14 mg/dl, total kolestrol düzeyleri 156,34 ±
29,61 mg/dl vs 118,53 ± 46,15 mg/dl, diastolik kan basıncı 81,92 ± 10,59 mm Hg vs 71,50 ± 7,27 mm Hg, sistolik kan basıncı 138,46 ± 21,59 mm Hg vs 114,50 ± 13,07 mm Hg olarak tespit edildi. Yapılan
istatistiksel analiz sonucunda değerlerin anlamlı (p<0,001) olduğu tespit
edildi. Sonuç
olarak uzun süre içme suyundaki yüksek orandaki inorganik arseniğin insanlarda
biyokimyasal parametreleri olumsuz yönde etkilediği ve arseniğin oluşturduğu
oksidatif strese bağlı olarak bu kişilerde farklı hastalıkların oluşma riskini
arttırabileceğini söyleyebiliriz.

Keywords

Arsenik, İntoksikasyon, Biyokimyasal parametreler, Kan basıncı

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