A MULTICYSTIC ULTRASONOGRAPHIC IMAGE OF ENDOMETRIUM IN TAMOXIFEN USE ; CASE REPORT

Year 2006, Issue: 010, 181 - 184, 15.05.2006

Emine Coşar Mehmet R. Helvacı

Abstract

Background: Tamoxifen is a nonsteroidal anti-estrogen that widely used as part of breast cancer. In addition to its anti-estrogenic properties, tamoxifen has a stimulatory effect on the endometrium. In this report we present a bizarre ultrasonographic image of endometrium in a patient receiving tamoxifen.Case: A 55 year-old postmenopausal woman gravida 4 parite 3 presented us for spotty like vaginal bleeding. She had surgery for breast cancer and took tamoxifen for two years. Pelvic examination was made, a multicystic grape like ultrasonographic image was detected.Conclusion: Early endometrial lesions can be detected by using transvaginal ultrasound in tamoxifen therapy. Oedema and enlargement of the stromal cells make different findings on the ultrasound.

Keywords

tamoxifen, ultrasound, endometrium

References

• [1] Cuzick J,2000. A brief review of the current breast cancer prevention trials and proposals for future trials. Eur J Cancer. 36: 1298-1302.
• [2] Gottardis MM, Robinson SP, Satyaswaroop PG: Contrasting actions of tamoxifen on endometrial and breast tumour growth in athymic Mouse. Cancer Res 1988;48: 812-815.
• [3] Tesoro MR, Borgida AF, MacLaurin NA, 1999. Transvaginal endometrial sonography in postmenopausal women taking tamoxifen. Obstet Gynecol. 93: 363-366.
• [4] Archiron R, Lipitz S, Sivan E, 1995. Changes mimicking endometrial neoplasia in postmenopausal, tamoxifen treated women with breast cancer:A transvaginal doppler study. Ultrasound Obstet Gynecol. 6: 116-120.
• [5] Goldstein SR, 1994. Unusual ultrasonographic appearence of the uterus in patients receivig tamoxifen. Am J Obstet Gynecol. 170: 447-451.