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SİNNAMİK ASİDİN SIÇAN İLEUM VE MESANE DÜZ KASLARI ÜZERİNDEKİ KASILMA VE GEVŞEME ETKİ MEKANİZMASININ ARAŞTIRILMASI

Year 2020, Issue: 044, 1 - 23, 30.06.2020

Abstract

Sinnamik Asit, Cinnamomi cortex (Tarçın) bitkisinde
yaygın olarak bulunan bir fenolik asit türevidir ve adını da tarçın bitkisinden
almıştır. Antimikrobial, Antitümöral, Antikanserojen ve Antifungal
özelliklerinin olduğu ve vazodilatör etkisi saptanmıştır.

Bu çalışma kontrol, atropin,
fentolamin, propranolol, nifedipin, tetraetil amonyum ve
atropin+fentolamin+propranolol uygulanan gruplar olmak üzere 7 farklı grupta
ileum ve mesane için ayrı ayrı gerçekleşmiştir. Çalışmada KCl veya karbakol ile
ön-kastırılmış ileum/mesane dokularına farklı antagonist ya da kanal
blokörlerinin uygulanması sonrası ilgili dokuların sinnamik aside karşı
kasılma-gevşeme cevapları incelenmiştir.

Sinnamik asit ileum ve
mesanede doza bağlı kasılma ve gevşemeler oluşturmuştur. Atropin ileumu daha
fazla kastırırken gevşeme cevaplarını değiştirmemiştir. Mesanede ise kasılma
cevaplarını inhibe ederken gevşemeyi arttırmıştır. Fentolamin ileum ve
mesanenin kasılma ve gevşeme cevapları değişmemiştir. Propranolol ileumun
kasılma cevaplarını inhibe etmiş gevşeme cevapları değişmemiştir. Mesanede ise
kasılma cevapları artarken gevşeme yanıtları değişmemiştir. Nifedipin ileumda
sinnamik asidin kasılma cevaplarını inhibe ederken gevşeme cevaplarını
değiştirmemiş, mesanede kasılma cevaplarını etkilemezken gevşeme cevaplarını arttırmıştır.
TEA ileumda kasılma ve gevşeme cevaplarını değiştirmemiş mesanede de kasılma
cevaplarını etkilemezken gevşeme cevaplarını arttırmıştır. Aynı anda yapılan
adrenerjik ve kolinerjik reseptör blokajı ileumda ve mesanede kasılma ve
gevşeme cevaplarını değiştirmiş fakat anlamlı olarak etkilememiştir.







Sonuç olarak sıçan ileum ve
mesane düz kasları üzerinde uyguladığımız Sinnamik asidin kullandığımız
reseptör antagonistleri ve kanal blokörlerinin dışında farklı reseptörler veya
yolaklar aracılığı ile de etkide bulunduğu düşünülmektedir.

References

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INVESTIGATION OF THE EFFECTION MECHANISM OF CINNAMIC ACID ON CONTRACTION AND RELAXATION OF SMOOTH MUSCLES OF ILEUM AND BLADDER OF RATS

Year 2020, Issue: 044, 1 - 23, 30.06.2020

Abstract

Cinnamic Acid is a phenolic acid derivative commonly found in Cinnamomi cortex (Cinnamon) plant, and it is named after cinnamon plant. It have Antimicrobial, Antitumoral, Anticancer and Antifungal properties and beyond that its vasodilator effect were also detected. This study was performed separately for ileum and bladder in 7 different groups, namely atropine, phentolamine, propranolol, nifedipine, tetraethyl ammonium and atropine + phentolamine + propranolol applied groups. In the study, the contraction-relaxation responses to cinnamic acid of the relevant tissues were examined after application of different antagonists or channel blockers to KCl or carbachol pre-contracted ileum / bladder tissues. Cinnamic acid caused constraction and relaxation of the ileum and bladder as dosage dependent manner. Atropine did not change the relaxation response while further contracting the ileum. It increased relaxation while inhibiting contraction responses in bladder. The contraction and relaxation responses of phentolamine on ileum and bladder was not changed. The propranolol inhibited the contraction responses of ileum, but did not change the relaxation responses. In bladder, the contraction responses increased, but relaxation responses did not change. Nifedipine did not alter the relaxation responses while inhibiting the response of contraction to cinnamic acid in ileum, and increasing relaxation responses without affecting the contraction responses in the bladder. TEA increased relaxation responses while it did not affect the contraction responses in bladder, but did not change contraction and relaxation responses in ileum. At the same time, the adrenergic and cholinergic receptor blockade performed at the same time altered the contraction and relaxation responses in the ileum and bladder, but did not significantly affect them. In conclusion, it is thought that cinnamic acid applied on rat ileum and bladder smooth muscles, is also influenced by different receptors or pathways other than receptor antagonists and channel blockers preferred by us.

References

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Details

Primary Language English
Subjects Structural Biology
Journal Section Articles
Authors

Ayhan Yılmaz 0000-0003-0410-8687

Hayri Dayıoğlu This is me 0000-0002-9270-8561

Fatih Alan 0000-0002-0561-6192

Publication Date June 30, 2020
Published in Issue Year 2020 Issue: 044

Cite

APA Yılmaz, A., Dayıoğlu, H., & Alan, F. (2020). INVESTIGATION OF THE EFFECTION MECHANISM OF CINNAMIC ACID ON CONTRACTION AND RELAXATION OF SMOOTH MUSCLES OF ILEUM AND BLADDER OF RATS. Journal of Science and Technology of Dumlupınar University(044), 1-23.

HAZİRAN 2020'den itibaren Journal of Scientific Reports-A adı altında ingilizce olarak yayın hayatına devam edecektir.