Viral Siğili Olan Hastalarda Kontrol Grubuna Kıyasla Daha Düşük Vitamin B12 Seviyeleri: Retrospektif Bir Çalışma

Year 2022, , 74 - 77, 30.04.2022

Gökşen Ertuğrul , Habibullah Aktaş

https://doi.org/10.18678/dtfd.1053249

Abstract

Amaç: Viral siğil, yaygın olarak görülen benign enfeksiyöz bir dermatozdur. HPV'ye maruz kalan herkesin neden siğil geliştirmediği belirsizliğini korumaktadır. Vitamin ve mineral eksikliklerinin doğal ve kazanılmış bağışıklığı zayıflatabileceği ve daha fazla enfeksiyon kapma eğilimine yol açabileceği bilinmektedir. Bu çalışma, viral siğili olan hastalarda vitamin B12, folik asit ve ferritin düzeylerinin değerlendirilmesinin potansiyel faydasını değerlendirmeyi amaçlamıştır.
Gereç ve Yöntemler: Bu geriye dönük çalışmaya, Ocak 2018 ve Aralık 2019 tarihleri arasında Karabük Üniversitesi Eğitim ve Araştırma Hastanesi dermatoloji polikliniğinde viral siğil tanısı almış olan 70 hasta dahil edildi. Kontrol grubu olarak cinsiyet ve yaş açısından viral siğil hastaları ile uyumlu olan 70 sağlıklı birey dahil edildi. Hastane otomasyon sisteminden her iki grubun serum vitamin B12, folik asit ve ferritin düzeyleri tespit edildi ve karşılaştırıldı.
Bulgular: Serum vitamin B12 düzeyi, viral siğili olan hasta grubunda kontrol grubuna göre istatistiksel olarak anlamlı derecede daha düşük tespit edildi (p=0,046). Serum ferritin düzeyleri viral siğil grubunda daha düşük bulunmakla birlikte, bu fark istatistiksel olarak anlamlı değildi (p=0,677). Folat seviyeleri açısından, viral siğil ve kontrol grupları arasında istatistiksel olarak anlamlı bir farklılık tespit edilmemiştir (p=0,879).
Sonuç: Serum vitamin B12 düzeyi düşük viral siğili olan hastalarda vitamin B12 replasman tedavisi düşünülebilir. Ayrıca viral siğil enfeksiyonu olan hastalarda vücutta demir depolama parametresi olan serum ferritin düzeyinin değerlendirilmesi önemlidir.

Keywords

Siğil, B12 vitamini, folik asit, ferritin, viral siğil

Lower Levels of Vitamin B12 Among Patients with Viral Warts Compared with Control Subjects: A Retrospective Study

Abstract

Aim: Viral wart is a common benign infectious dermatosis. It remains unclear why not everyone exposed to HPV develops warts. It is known that vitamin and mineral deficiencies can affect impair natural and acquired immunity and lead to a tendency to get more infections. This study aimed to determine the potential utility of evaluating vitamin B12, folic acid, and ferritin levels in patients with viral warts.
Material and Methods: In this retrospective study, 70 patients who were diagnosed with viral warts in the dermatology outpatient clinic of Karabük University Training and Research Hospital between January 2018 and December 2019 were included. 70 healthy individuals matched with viral wart patients in terms of gender and age were included as the control group. Serum vitamin B12, folic acid, and ferritin levels of both groups were detected and compared from the hospital automation system.
Results: Vitamin B12 level was detected statistically significantly lower in the viral wart group as compared to the control group (p=0.046). Although serum ferritin levels were found lower in the viral wart group, this difference was not statistically significant (p=0.677). No statistically significant difference was detected between the viral wart and control groups in terms of folate levels (p=0.879).
Conclusion: In patients with viral warts with low serum vitamin B12 levels, replacement therapy could be considered. Also, the evaluation of serum ferritin level, an iron storage parameter in the body, is important in patients with viral warts infection.

Keywords

wart, vitamin B12, folic acid, ferritin, viral warts

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