Duloxetine-Induced Sleep Bruxism and Tooth Fracture in Fibromyalgia

Abstract

Duloxetine is a serotonin-norepinephrine reuptake inhibitor that is approved for the treatment of fibromyalgia. Duloxetine has many side effects such as nausea, somnolence, insomnia, decreased appetite, dry mouth, and constipation. Sleep bruxism is also a very rare side effect of duloxetine. In this case report, a case of a 35-year-old male patient who developed sleep bruxism in the 4th week after duloxetine use, and fracture of the 1st upper molar tooth which had previously undergone root canal treatment after severe bruxism in the 6th week was presented. Duloxetine treatment was stopped and treatment was continued with amitriptyline. The patient had a significant reduction in both bruxism and fibromyalgia symptoms after the amitriptyline treatment. Bruxism symptoms were not observed after one year of follow-up.

Keywords

• Duloxetine
• Sleep bruxism
• tooth fracture
• fibromyalgia

Fibromiyaljide Duloksetin Kaynaklı Uyku Bruksizmi ve Diş Kırılması

Abstract

Duloksetin, fibromiyalji tedavisi için onaylanmış bir serotonin-norepinefrin geri alım inhibitörüdür. Duloksetinin bulantı, uyuklama, uykusuzluk, iştah azalması, ağız kuruluğu ve kabızlık gibi birçok yan etkisi vardır. Uyku bruksizmi de duloksetinin çok nadir görülen bir yan etkisidir. Bu olgu sunumunda, duloksetin kullanımından sonra 4. haftada uyku bruksizmi gelişen ve 6. haftada şiddetli bruksizm sonrası daha önce kanal tedavisi görmüş olan 1. üst molar dişinde kırık gelişen 35 yaşında bir erkek hasta sunulmuştur. Kullanmakta olduğu duloksetin tedavisi kesildi ve tedaviye amitriptilin ile devam edildi. Amitriptilin tedavisinden sonra hastanın hem bruksizm hem de fibromiyalji semptomlarında belirgin bir azalma görüldü. Bir yıllık takip sonrasında bruksizm semptomları görülmedi.

Keywords

• Duloksetin
• Uyku bruksizmi
• diş kırılması
• fibromiyalji

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