Efficacy and Tolerability of Topical Dapsone vs Benzoyl Peroxide in Mild to Moderate Acne Vulgaris Treatment: A Retrospective Study

Abstract

Aim: Acne vulgaris is a disease of the pilosebaceous unit and a chronic inflammatory process. This study aimed to compare topical 5% dapsone and 10% benzoyl peroxide in terms of efficacy, side effects, and patient satisfaction in mild to moderate acne. Material and Methods: The patients who applied to the dermatology outpatient clinic with the complaint of acne between June 20, 2022, and September 20, 2022, and were diagnosed with mild and moderate acne vulgaris, were retrospectively evaluated. Forty-eight patients in the dapsone group and 53 in the benzoyl peroxide group were included in this study. Results: At the end of the treatment, a statistically significant difference was found between the two groups in terms of ISGA values and improvement percentage in ISGA, improvement was higher in the dapsone group (both p=0.001). A statistically significant difference was found between the groups in terms of the percentage decrease in lesion counts of closed comedones, papules and pustules, inflammatory and total lesions (decreasement was higher in the dapsone group, p=0.038 for closed comedones, p=0.006 for total lesions and p<0.001 for others). There was no dissatisfied patient in the group using dapsone (p<0.001). Among the side effects, erythema was more common during the whole treatment, and dryness and burning-stinging sensation were higher at the end of the first month in the benzoyl peroxide group. Conclusion: Topical 5% dapsone is effective in the treatment of mild to moderate acne and is safe in terms of side effects compared to topical 10% benzoyl peroxide.

Keywords

• acne vulgaris
• benzoyl peroxide
• dapsone

Hafif-Orta Şiddetli Akne Vulgaris Tedavisinde Topikal Dapson ve Benzoil Peroksitin Etkinlik ve Tolere Edilebilirliği: Retrospektif Bir Çalışma

Abstract

Amaç: Akne vulgaris, pilosebase ünitenin bir hastalığıdır ve kronik inflamatuar bir süreçtir. Bu çalışmanın amacı hafif ve orta şiddetli akne hastalarında, topikal %5’lik dapson ile topikal %10’luk benzoil peroksiti etkinlik, yan etki ve hasta memnuniyeti açısından karşılaştırmaktır. Gereç ve Yöntemler: Dermatoloji polikliniğine 20 Haziran 2022 ile 20 Eylül 2022 tarihleri arasında akne şikayeti ile başvuran ve hafif ve orta şiddette akne vulgaris tanısı almış olan hastalar geriye dönük olarak değerlendirildi. Bu çalışmaya, dapson grubunda 48 ve benzoil peroksit grubunda 53 hasta dahil edildi. Bulgular: Tedavi sonunda, ISGA değerleri ve ISGA'daki iyileşme yüzdesi açısından iki grup arasında istatistiksel olarak anlamlı bir farklılık bulundu, dapson grubunda iyileşme daha fazlaydı (her ikisi için de p=0,001). Kapalı komedon, papül ve püstül, inflamatuvar lezyon ve toplam lezyonların lezyon sayılarındaki azalma yüzdeleri açısından iki grup arasında istatistiksel olarak anlamlı bir farklılık bulundu (dapson grubunda azalma daha fazlaydı, kapalı komedonlar için p=0,038, toplam lezyonlar için p=0,006 ve diğerleri için p<0,001). Dapson kullanan grupta memnun olmayan hasta yoktu (p<0,001). Yan etkiler arasında eritem tüm tedavi süresi boyunca daha sık görüldü, kuruluk ve yanma-batma hissi benzoil peroksit grubunda birinci ayın sonunda daha fazlaydı. Sonuç: Topikal %5’lik dapson, hafif ve orta şiddetli akne tedavisinde etkilidir ve topikal %10 benzoil peroksit ile karşılaştırıldığında yan etki açısından güvenlidir.

Keywords

• akne vulgaris
• benzoil peroksit
• dapson

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