İş Sağlığı ve Biyogüvenlik Kapsamında Hayvan Deneyleri Çalışmaları ve Laboratuvar Güvenliği

Year 2024, , 19 - 23, 30.06.2024

Münir Uçak

https://doi.org/10.18678/dtfd.1504050

Abstract

İş sağlığı ve biyogüvenlik terimleri çalışanların ve üzerinde çalışma yapılan canlı materyalin etik değerler, güvenilir yöntemler, risk ve tehlikelere karşı alınacak bir dizi önlemlere dair bilimsel yaklaşımları içermektedir. Biyoteknoloji kapsamında gerçekleştirilen araştırma ve geliştirme faaliyetleri, kendi fiziki alanı olan laboratuvar koşullarında pek çok riski bünyesinde barındırmaktadır. Bu risklerin analiz edilerek, oluşmadan önlem alınmasına yönelik birçok önlem ve uygulama tanımlanmış ve bu tanımlar doğrultusunda laboratuvar rehberleri oluşturulmuştur. Laboratuvar koşullarında deney hayvanları ile yapılan çalışmalar sırasında fiziki koşullar, ekipman ve materyaller, deneklere uygulanan tedaviler, ihmaller veya araştırmacı veya uzmandan kaynaklanan hatalı uygulamalar nedeniyle güvenli çalışma kuralları ihlal edilebilmektedir. Hayvan deneyleri çalışmalarında biyogüvenlik ise kendi seviyesinde özelleşmiş laboratuvarların kılavuzlarında bildirilen, çalışanları, denekleri ve laboratuvar dışındaki yaşamı koruma altına alan bir dizi etik şart ve uygulamalarından ibarettir. Bu derlemede genel olarak farklı biyogüvenlik seviyelerinde ortaya çıkabilecek olası risk ve tehlikeler ile bunlara karşı alınabilecek önlem ve uygulamalar değerlendirilmiştir. Bu sayede, hayvan deneyleri çalışmalarında laboratuvar ve biyogüvenlik kriterlerinin geliştirilmesine katkı sağlaması amaçlanmıştır.

Keywords

İş sağlığı ve güvenliği, biyogüvenlik, deney hayvanları

Animal Experiments and Laboratory Safety within the Scope of Occupational Health and Biosafety

Abstract

Occupational health and biosecurity terms include scientific approaches regarding ethical values, reliable methods, and a series of precautions to be taken against risks and hazards for employees and the living material being studied. Research and development activities carried out within the scope of biotechnology involve many risks under laboratory conditions, which are their own physical area. Many precautions and practices have been defined to analyze these risks and take precautions before they occur, and laboratory guides have been created in line with these definitions. During studies carried out with experimental animals under laboratory conditions, safe working rules may be violated due to physical conditions, equipment and materials, treatments applied to the subjects, negligence, or faulty practices caused by the researcher or expert. Biosafety in animal experiments consists of a set of ethical conditions and practices declared in the guidelines of specialized laboratories at their own level, protecting employees, subjects, and life outside the laboratory. In this review, possible risks and dangers that may arise at different biosafety levels and the precautions and practices that can be taken against them are evaluated. In this way, it was aimed to contribute to the development of laboratory and biosafety criteria in animal experiments.

Keywords

Occupational health and safety, biosecurity, experimental animals

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