Salivary Duct Carcinoma of the Parotid Gland: A Case Report

Abstract

Salivary duct carcinoma is a highly aggressive tumor characterized by an extensive cervical lymph node involvement, and distant metastasis. The majority of patients were male, and aged 50 years or older. Presenting symptoms have included a painful, rapidly enlarging, firm mass, usually associated with facial nerve paralysis. The treatment of salivary duct carcinoma is surgical. Total parotidectomy with neck dissection, and radiation therapy appear to be appropriate for local and regional control of this tumor. Despite aggressive treatment, prognosis is poor, with a frequency of distant metastasis ranging from 46% to 66% and a mortality rate of 60% to 75%. In this paper, we report the case of a 67 - year-old man with salivary duct carcinoma of the parotid gland. Both the differential diagnosis and the surgical treatment options are presented, and the literature is reviewed

Keywords

• Parotid gland,salivary duct carcinoma

Parotis Bezi Duktal Karsinomu: Olgu Sunumu

Abstract

Tükürük bezi duktal karsinomu yaygın servikal lenf nodu tutulumu ve uzak metastaz ile karakterize oldukça agresif bir tümördür. Hastaların büyük çoğunluğunu 50 yaş veya üzeri erkek olgularoluşturur. Genellikle fasiyal paralizinin eşlik ettiği, hızlı büyüyen, ağrılı sert bir kitle olarak ortaya çıkan duktal karsinomun tedavisi cerrahidir. Total parotidektomi, boyun diseksiyonu ve postoperatif radyoterapi bu tümörün lokal ve bölgesel kontrolünde uygun bir tedavi seçeneği olarak görülmektedir. Agresif tedaviye rağmen prognoz çok kötüdür. Uzak metastaz oranı % 46 ile % 66, ölüm oranı ise % 60 ile % 75 arasında değişmektedir. Bu yazıda 67 yaşında erkek hastada parotis bezi duktal karsinomu olgusu sunulmuştur. Hastalığın hem ayırıcı tanısı hem de cerrahi tedavi seçenekleri sunulmuş ve literatür gözden geçirilmiştir

Keywords

• Parotis bezi,tükürük bezi duktal karsinomu

References

1. Hosal AS, Fan C, Barnes L, et al. Salivary duct carcinoma. Otolaryngol Head Neck Surg. 129:720-725, 2003.
2. de Araşjo VC, Kowalski LP, Soares F, et al. Salivary duct carcinoma: cytokeratin 14 as a marker of in-situ intraductal growth. Histopathology. 41:244-249, 2002.
3. Madrigal B, García J, De Vicente JC. Salivary duct carcinoma: an unusual case of long-term evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 88:597- 602, 1999.
4. Valeri RM, Hadjileontis C, Skordalaki A, et al. Salivary duct carcinoma of the parotid gland: report of a rare case with a comparative study of aspiration cytology and histomorphology. Acta Cytol. 49:61-64, 2005.
5. Lewis JE, McKinney BC, Weiland LH, et al. Salivary duct carcinoma. Clinicopat-hologic and immunohistoche-mical review of 26 cases. Cancer. 77:223-230, 1996.
6. Akın İ, Erdal F, Han Ü ve ark. Larenksin minör tükrük bezi orijinli duktal karsinomu. K.B.B. ve Baş Boyun Cerrahisi Dergisi. 7:110-113, 1999.
7. Chen KT, Hafez GR. Infiltrating salivary clinicopathologic study of five cases. Arch Otolaryngol. 107:37-39, 1981.
8. Garland TA, Innes DJ, Fechner RE. Salivary duct carcinoma: an analysis of four cases with review of literature. Am J Clin Pathol. 81:436-441, 1984.

9. Khurana KK, Pitman MB, Powers CN, et al. Diagnostic pitfalls of aspiration cytology of salivary duct carcinoma. Cancer. 25:373-378, 1997.
10. Frankenthaler RA, Luna MA, Lee SS, et al. Prognostic variables in parotid gland cancer. Arch Otolaryngol Head Neck Surg. 117:1251-1256, 1991.
11. Colmenero Ruiz C, Patrón Romero M, Martín Pérez M. Salivary duct carcinoma: a report of nine cases. J Oral Maxillofac Surg. 51:641-646, 1993.
12. Guzzo M, Di Palma S, Grandi C, et al. Salivary duct carcinoma: clinical characteristics and treatment strategies. Head Neck. 19:126-133, 1997.
13. Brandwein MS, Jagirdar J, Patil J, et al. Salivary duct carcinoma (cribriform salivary carcinoma clinicopathologic chemical study of 12 cases. Cancer. 65:2307-2314, 1990. ducts). A immunohisto
14. Luna MA, Batsakis JG, Ordóñez NG, et al. Salivary clinicopathologic distinctive types. Semin Diagn Pathol. 4:117- 135, 1987. a of three
15. Afzelius LE, Cameron WR, Svensson C. Salivary duct carcinoma: a clinicopathologic study of 12 cases. Head Neck. 9:151-156, 1987.
16. Delgado R, Vuitch F, Albores-Saavedra J. Salivary duct carcinoma. Cancer. 72:1503- 1512, 1993.
17. Barnes L, Rao U, Krause J, et al. Salivary duct carcinoma. Part I. A clinicopathologic evaluation and DNA image analysis of 13 cases with review of the literature. Oral Surg Oral Med Oral Pathol. 78:64-73, 1994.
18. Hui KK, Batsakis JG, Luna MA. Salivary duct adenocarcinoma: a high grade malignancy. J Laryngol Otol. 100:105-14, 1986.