OCULAR HEMODYNAMICS IN NON-EXUDATIVE AGE RELATED MACULAR DEGENERATION

Abstract

Purpose: To explore changes in retrobulbar ocular blood flow dynamics in patients with nonexudative age- related macular degeneration (ARMD). Materials and Methods: 52 patients (M=28, F=24) with ARMD and 45 age-matched healthycontrols (M=23, F=22) were included in our evaluation. Full ophthalmic examination and orbitalcolor Doppler imaging was performed in both eyes. Peak systolic and end-diastolic velocities,resistive and pulsatility indices were considered as Doppler blood flow parameters in ourevaluation. Central retinal, ophthalmic, temporal posterior ciliary and nasal posterior ciliaryarteries measurements were taken. Results: The mean age was 65.90 ± 2.05 in ARMD and 60.95 ± 1.34 in thecontrol group. Pulsatility and resistive indices in ophthalmic arteries of ARMD patients weresignificantly higher than the control group. The peak systolic and end-diastolic velocities innasal and temporal posterior ciliary arteries were significantly lower whereas pulsatility andresistive indices were significantly higher in ARMD compared to the control group. Peak systolicand end-diastolic velocities and resistive indices were significantly higher in ARMD cases,especially in posterior ciliary arteries supplying the choroid. Conclusion: Perfusion defects of the retrobulbar vasculatures were significantly higher inARMD compared to the healthy controls

Keywords

• Non-exudative age-related macular degeneration,choroidal perfusion,Dopplerultrasound,ocular hemodynamics

Non-Eksudatif Yaşa Bağlı Makula Dejenerasyonunda Oküler Hemodinami

Abstract

Amaç: Amaç: Non-eksudatif yaşa bağlı makula dejenerasyonu bulunan hastalarda retrobulbaroküler kan akım hemodinamisindeki değişikliklerin değerlendirilmesi (ARMD). Materyal ve Metod: ARMD’si olan 52 hasta (E=28, K=24) ve 45 tane yaşı uyumlu sağlıklıbirey (E=23, K=22) çalışmaya dahil edildi. Her iki grupta, bilateral tam oftalmik muayene veorbital renkli doppler görüntüleme gerçekleştirildi. Doppler kan akım parametreleri olarak piksistolik ve end-diyastolik hızlar, rezistif ve pulsatilite indeksleri belirlendi. Santral retinal,oftalmik, temporal posterior siliyer ve nazal posterior siliyer arterlerde ölçümler yapıldı. Sonuçlar: ARMD’li grupta yaş ortalaması 65.90 ± 2.05 , kontrol grubunda ise 60.95 ±1.34 idi. ARMD hastaların oftalmik arterlerinde, pulsatilite ve resistif indeksleri kontrolgrubuna göre anlamlı yüksek bulundu. ARMD’li grupta kontrol grubuna göre, temporal posteriorsiliyer ve nazal posterior siliyer arterlerde, pik sistolik ve end-diyastolik hızlar anlamlı düşük,pulsatilite ve resistif indeksleri ise anlamlı yüksekti. Pik sistolik, end-diyastolik hızlar ve rezistifindeksler ARMD’li hastalarda, özellikle koroidi besleyen posterior siliyer arterlerde anlamlıyüksek bulundu. Sonuç: Retrobulbar vasküler yapılarda perfüzyon defektleri, ARMD’li grupta kontrol grubunakıyasla anlamlı yüksektir

Keywords

• Yaşa bağımlı non-eksudatif makular dejenerasyon,koroidal perfüzyon,doppler ultrason,oküler hemodinami

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