Bronchocentric Granulomatosis

Abstract

Bronchocentric granulomatosis is a destructive, granulomatous lesion of the bronchi andbronchioles. Bronchocentric granulomatosis is often divided clinically into two groups: patientswith or without asthma. In all cases, a careful search for an underlying cause should beconsidered. Radiographic presentation of bronchocentric granulomatosis is varied and includessolitary nodules, multiple nodules, atelectasis and areas of consolidation. The upper lobes aremore commonly involved than the lower lobes. Many patients with unexplained or idiopathicbronchocentric granulomatosis improve without medical therapy. A course of systemicglucocorticoids has resulted in improvement in a few case reports; a small number of patientshave recurrent or persistent disease requiring longer-term glucocorticoid treatment

Keywords

• Bronchi and bronchioles,bronchocentric granulomatosis,destruction

BRONKOSENTRİK GRANÜLOMATOZİS

Abstract

Bronkosentrik granülomatozis (BG) bronş ve bronşiyollerin hava yolu hasarına vermiş olduklarıözgün olmayan yanıtı temsil eden destrüktif granülomatöz lezyonlardır. İlk olarak 1973 yılındaLiebow tarafından tanımlanmıştır. Vakaların yaklaşık yarısı astım ve alerjik bronkopulmoneraspergillozis ile ilişkilidir. İdiopatik durumlar dışında mikobakteryel ve fungal enfeksiyonlar,romatolojik hastalıklar, Wegener, kronik granülomatöz hastalık, glomerülonefrit, sklerit, diabetesinsipitus, red cell aplazi, pulmoner ekinokok, bronkojenik karsinom ve influenza A virüsü ileilişkili durumlar da rapor edilmiştir. Spesifik bir klinik tablodan ziyade, histopatolojik olaraktanı konulan bir hastalıktır. Bu derlemede BG’in klinik, radyolojik ve patolojik bulguları gözdengeçirilecek eşlik eden hastalıklar hakkında genel bilgi verilmiştir

Keywords

• Bronkosentrik granülomatozis,bronş ve bronşiol,destrüksiyon

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