Gastrik Skuamöz Hücreli Karsinom: Olgu Sunumu

Öz

Gastrik skuamöz hücreli karsinom nadir görülür ve çoğunlukla yaşlı bireyleri etkiler. Yetmiş sekiz yaşında kadın hasta bulantı, kusma, kilo kaybı ve epigastrik ağrı şikayeti ile başvurmuştur. Endoskopik incelemede posterior bölgede büyük kurvaturdan antrum'a kadar ülsero vejetatif bir kitle saptanmıştır. Özofagogastrik bileşke ve kardiya ayrıca normal olarak izlenmiştir. Hastaya tanı amaçlı endoskopik biyopsi yapılmıştır. Histopatolojik olarak, tümörün desmoplastik bir stromada infiltre yuvalar oluşturan atipik skuamöz hücrelerden meydana geldiği görülmüştür. İmmünohistokimyasal olarak neoplastik hücrelerde p40 ve p63 ile pozitiflik saptanmış olup CEA ile immünekspresyon izlenmemiştir. Başka bir organ kaynaklı buraya metastazı düşündürecek radyolojik bulgu da saptanmamıştır. Burada bir gastrik skuamöz hücreli karsinom vakası sunulmuş olup klinik ve morfolojik özellikleri literatür eşliğinde tartışılmıştır.

Anahtar Kelimeler

• Mide,skuamöz hücre,karsinom

Gastric Squamous Cell Carcinoma: A Case Report

Abstract

Gastric squamous cell carcinoma is rarely seen and affects mostly elder patients. A 78-year-old woman presented with nausea, vomiting, weight loss, and epigastric pain. There was an ulcero-vegetative mass in the posterior area from the large curvature to the antrum in the endoscopic examination. The gastroesophageal junction and cardia were also normal. We performed a diagnostic endoscopic biopsy. Histopathologically, it was composed of atypical squamous cells displaying infiltrating solid nests in a desmoplastic stroma. Immunohistochemically, the neoplastic cells also showed positivity for p40 and p63 and negativity for CEA. Besides, there was no radiological evidence of metastasis from other organs. We herein presented a case of gastric squamous cell carcinoma and discussed its clinical and morphological features with the literature.

Keywords

• Stomach,squamous cell,carcinoma

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