The Prediction of Allergic Proctocolitis by Using Hematological Parameters

Year 2020, , 119 - 123, 30.08.2020

Sebahat Çam

https://doi.org/10.18678/dtfd.749607

Cited By: 1

Abstract

Aim: Allergic proctocolitis (AP) is a common cause of rectal bleeding in infants. There is no diagnostic tool specific to the disease. The aim of the study was to evaluate hemogram parameters as a marker of inflammation in patients with AP.

Material and Methods: The files of patients who were exclusively breastfed and diagnosed as food protein induced AP were examined retrospectively. A hundred and fifty patients diagnosed with AP were included in the study. The same number of healthy babies formed the control group. Parameters in complete blood count were compared between patient and control groups. Rectosigmoidoscopic examination was performed to confirm the diagnosis in patients who could not achieve complete improvement with diet therapy, and hemogram parameters were evaluated according to eosinophilic infiltration in biopsies.

Results: The mean platelet volume (MPV) values (p<0.001) and eosinophil percentages (p=0.001) of the AP group were higher than the control group. The mean hemoglobin values of the AP group were statistically significantly lower than the control group (p<0.001). No statistically significant difference was found between patient and control groups in terms of white blood cell (WBC) count, platelet count, platelet distribution width (PDW) and neutrophil/lymphocyte ratio (NLR). WBC count, platelet count, hemoglobin, MPV and C-reactive protein (CRP) values were similar between groups of patients according to the number of eosinophils in colon biopsies.

Conclusion: We observed a significantly higher MPV values and eosinophil percentages in patients with AP. These parameters maybe helpful in diagnosis of AP.

Keywords

Allergy, proctocolitis, hemogram

Allerjik Proktokolit Öngörüsünde Hematolojik Parametrelerin Kullanımı

Abstract

Amaç: Alerjik proktokolit (AP), bebeklerde görülen rektal kanamanın yaygın bir nedenidir. Bu hastalığa özgü olan bir tanı aracı yoktur. Çalışmanın amacı, AP tanısı konmuş olan hastalarda inflamasyonun bir belirteci olarak hemogram parametrelerini değerlendirmektir.

Gereç ve Yöntemler: Sadece anne sütü ile beslenen ve gıda proteini kaynaklı AP tanısı konan hastaların dosyaları geriye dönük olarak incelendi. AP tanısı konulmuş olan 150 hasta çalışmaya dahil edildi. Aynı sayıda herhangi bir sağlık sorunu saptanmayan bebek ise kontrol grubunu oluşturdu. Tam kan sayımındaki parametreler hasta ve kontrol grupları arasında karşılaştırıldı. Diyet tedavisi ile tam iyileşme sağlayamayan hastalarda tanıyı doğrulamak için ilave rektosigmoidoskopik inceleme yapıldı ve hemogram parametreleri biyopsilerdeki eozinofil infiltrasyon düzeyleri dikkate alınarak değerlendirildi.

Bulgular: AP grubunun ortalama trombosit hacmi (mean platelet volume, MPV) değerleri (p<0.001) ve eozinofil yüzdeleri (p=0.001) kontrol grubundan daha yüksekti. AP grubunun ortalama hemoglobin değerleri kontrol grubundan istatistiksel olarak anlamlı derecede daha düşüktü (p<0.001). Hasta ve kontrol grupları arasında beyaz kan hücresi (white blood cell (WBC) sayısı, trombosit sayısı, trombosit dağılım genişliği (platelet distribution width, PDW) ve nötrofil/lenfosit oranı (NLR) açısından istatistiksel olarak anlamlı bir fark bulunmadı. WBC sayısı, trombosit sayısı, hemoglobin, MPV ve C-reaktif protein (CRP) değerleri, kolon biyopsilerindeki eozinofil sayısına göre hasta grupları arasında benzerdi.

Sonuç: AP'li hastalarda anlamlı olarak yüksek MPV değerleri ve eozinofil yüzdeleri gözlendi. Bu parametreler AP tanısında yardımcı olabilir.

Keywords

Allerji, proktokolit, hemogram

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