Year 2018, Volume 20 , Issue 1, Pages 11 - 15 2018-08-03

Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging
Gliom Evrelemesinde Patolojik İndekslerin (Ki-67, p53) ve Perfüzyon/Difüzyon MR Parametrelerinin Karşılaştırılması

Gülhan ERTAN [1] , Sıla ULUS [2] , Aslı ÇAKIR [3]


Aim: In this study, we aim to determine the diffusion characteristics of grade II astrocytomas and glioblastomas (GBM), and to determine the ability of apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), Ki-67, and p53 values for the preoperative stratification of these tumors.

Material and Methods: MRI scans of 24 patients who underwent surgery for brain tumors in our hospital between 2014 and 2017 with grade II diffuse astrocytoma or GBM were retrospectively reviewed. The ADC and rCBV values were measured from inside the tumor and from the normal white matter of symmetric contralateral hemisphere. Ki-67 and p53 values were recorded from the pathology reports. Perfusion weighted imaging, diffusion weighted imaging, Ki-67, and p53 values were analyzed for differences between low-grade and high-grade astrocytomas.

Results: In grade II astrocytomas, the ADC values significantly increased compared to contralateral normal hemisphere, while in GBMs they were slightly increased. The success of rCBV using a value of 2 in distinguishing high- and low-grade astrocytomas was statistically significant and 100% accurate. As the min ADC value declined in GBMs the p53 score increased. Similarly, the p53 score increased as the min ADC and the average ADC values of GBM in the contralateral normal white matter (WM) declined.

Conclusion: Utilizing an rCBV value of 2 to distinguish grade II from grade IV astrocytomas is superior to relying on ADC values to predict grade. The decline in the ADC values of GBM in the normal WM of contralateral hemisphere corroborates the notion of a diffuse neoplastic process.

Amaç: Bu çalışmada amacımız, derece II astrositom ve glioblastomların (GBM) difüzyon karakteristiklerini belirlemek ve görünür difüzyon katsayısı (ADC), rölatif serebral kan hacmi (rCBV), Ki-67 ve p53 değerlerinin bu tümörlerin preoperatif sınıflanmasındaki yeterliklerini belirlemektir.

Gereç ve Yöntemler: 2014 ve 2017 yılları arasında derece II diffüz astrositom veya GBM nedeniyle hastanemizde ameliyat edilen 24 hastanın MRG bulguları retrospektif olarak incelendi. ADC ve rCBV değerleri tümörün içinden ve simetrik kontralateral normal beyaz hemisferden ölçüldü. Patoloji raporlarından Ki-67 ve p53 değerleri kaydedildi. Perfüzyon ağırlıklı görüntüleme, difüzyon ağırlıklı görüntüleme, Ki-67 ve p53 değerleri düşük dereceli ve yüksek dereceli astrositomlar arasındaki farklar açısından analiz edildi.

Bulgular: Derece II astrositomlarda, ADC değerleri kontralateral normal hemisfer ile karşılaştırıldığında önemli ölçüde artmış, GBM'lerde ise hafif artmıştır. Yüksek ve düşük dereceli astrositomları ayırt etmek için eşik değerin 2 olarak kabul edildiği rCBV'nin başarısı istatistiksel olarak anlamlıdır ve %100 doğrudur. GBM'lerde min ADC değeri azaldıkça, p53 skoru artmıştır. Benzer şekilde, p53 skoru, kontralateral normal beyaz ak maddede minimum ADC ve GBM'nin ortalama ADC değerleri azaldıkça artmıştır.

Sonuç: Glioblastomları, derece II astrositomlardan ayırt etmek için rCBV değerini 2 kullanmak, dereceyi belirlemek için ADC değerlerine dayanmaktan daha üstündür. GBM'li hastalarda kontralateral hemisferin normal ak maddesindeki ADC değerlerinde görülen düşüş, yaygın bir neoplastik süreç düşüncesini desteklemektedir.

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Primary Language en
Subjects Medicine
Journal Section Research Article
Authors

Author: Gülhan ERTAN (Primary Author)
Institution: ISTANBUL MEDIPOL UNIVERSITY
Country: Turkey


Orcid: 0000-0002-9313-3165
Author: Sıla ULUS
Institution: ACIBADEM UNIVERSITY
Country: Turkey


Author: Aslı ÇAKIR
Institution: ISTANBUL MEDIPOL UNIVERSITY

Dates

Publication Date : August 3, 2018

Bibtex @research article { dtfd454072, journal = {Duzce Medical Journal}, issn = {}, eissn = {1307-671X}, address = {}, publisher = {Duzce University}, year = {2018}, volume = {20}, pages = {11 - 15}, doi = {10.18678/dtfd.454072}, title = {Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging}, key = {cite}, author = {Ertan, Gülhan and Ulus, Sıla and Çakır, Aslı} }
APA Ertan, G , Ulus, S , Çakır, A . (2018). Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging . Duzce Medical Journal , 20 (1) , 11-15 . DOI: 10.18678/dtfd.454072
MLA Ertan, G , Ulus, S , Çakır, A . "Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging" . Duzce Medical Journal 20 (2018 ): 11-15 <https://dergipark.org.tr/en/pub/dtfd/issue/38727/454072>
Chicago Ertan, G , Ulus, S , Çakır, A . "Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging". Duzce Medical Journal 20 (2018 ): 11-15
RIS TY - JOUR T1 - Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging AU - Gülhan Ertan , Sıla Ulus , Aslı Çakır Y1 - 2018 PY - 2018 N1 - doi: 10.18678/dtfd.454072 DO - 10.18678/dtfd.454072 T2 - Duzce Medical Journal JF - Journal JO - JOR SP - 11 EP - 15 VL - 20 IS - 1 SN - -1307-671X M3 - doi: 10.18678/dtfd.454072 UR - https://doi.org/10.18678/dtfd.454072 Y2 - 2018 ER -
EndNote %0 Düzce Tıp Fakültesi Dergisi Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging %A Gülhan Ertan , Sıla Ulus , Aslı Çakır %T Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging %D 2018 %J Duzce Medical Journal %P -1307-671X %V 20 %N 1 %R doi: 10.18678/dtfd.454072 %U 10.18678/dtfd.454072
ISNAD Ertan, Gülhan , Ulus, Sıla , Çakır, Aslı . "Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging". Duzce Medical Journal 20 / 1 (August 2018): 11-15 . https://doi.org/10.18678/dtfd.454072
AMA Ertan G , Ulus S , Çakır A . Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging. Duzce Medical Journal. 2018; 20(1): 11-15.
Vancouver Ertan G , Ulus S , Çakır A . Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging. Duzce Medical Journal. 2018; 20(1): 11-15.
IEEE G. Ertan , S. Ulus and A. Çakır , "Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging", Duzce Medical Journal, vol. 20, no. 1, pp. 11-15, Aug. 2018, doi:10.18678/dtfd.454072