Evaluation of Serum Anti-Neutrophil Cytoplasmic Antibody in Patients With Behçet’s Disease

Year 2005, Volume: 7 Issue: 1, 15 - 18, 01.03.2005

Mualla Uzun Polat Güler Vahaboğlu Meral Ekşioğlu Ufuk Önde

Abstract

Behçet’s disease is a chronic illnes with unknown etiology and associated with oral aphtae, genital ulceration and uveitis. In this study ANCA positivity which was previously reported in some patients, was investigatedin patients with Behçet’s disease. This study was performed on 32 patients , 21 female and 11 male, who are between 20-59 year old and attended to the Ministry of Health, Ankara Training and Research Hospital Department of Dermatology between June 2002 and January 2003. Diagnosis was made according to the International Study Group Criteria. Serum c-ANCA and p-ANCA were negative in all patients. As a result, although Behçet’s disease mimics to some ANCA positive vasculitis, our results support the theory that ANCA does not have a role in the pathogenesis of Behçet’s disease

Keywords

Behçet’s disease, ANCA

Behçet Hastalarında Serum Anti-Nötrofil Sitoplazmik Antikor Varlığının Araştırılması

Abstract

Behçet hastalığı; ağızda aft, genital ülserasyon ve üveitle birlikte seyreden, etyolojisi bilinmeyen, kronik bir hastalıktır. Bu çalışmada, Behçet hastalarında daha önce bazı vakalarda bildirilen ANCA pozitifliği araştırıldı. Çalışma, Haziran 2002 - Ocak 2003 tarihleri arasında S.B. Ankara Eğitim ve Araştırma Hastanesi Dermatoloji Polikliniğine başvuran 21’i kadın, 11’i erkek, yaşları 20-59 yıl arasında değişen, 32 Behçet hastası ile gerçekleştirildi. BH tanısı, Uluslararası Çalışma Grubu Tanı Kriterlerine göre kondu. Ölçümlerde tüm hastalarda serum c-ANCA ve p-ANCA’nın negatif olduğu saptandı. Sonuç olarak Behçet hastalığı, ANCA pozitifliği gösteren vaskülitlerle benzerlik göstermesine rağmen, bu çalışma Behçet hastalığının patogenezinde ANCA’nın rolü olmadığı görüşünü desteklemektedir

Keywords

Behçet hastalığı, ANCA

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