Asymmetrıcal Dımethylargınıne (ADMA)

Year 2005, Volume: 7 Issue: 2, 36 - 41, 01.07.2005

Güler Buğdaycı Erdinç Serin

Abstract

Asymmetric dimethylarginine (ADMA) is the principal endogenous inhibitor of nitric oxide synthase. It regulates rates of nitric oxide (NO) formation. There is abundant evidence that the endothelium plays a crucial role in the maintenance of vascular tone and structure. One of the major endothelium-derived vasoactive mediators is nitric oxide , which has been characterized as an "endogenous anti-atherosclerotic molecule". Thus, ADMA might be thought as a key role contributing to endothelial dysfunction. Recently, it was found that ADMA was significantly elevated in animals and humans with hypercholesterolemia. ADMA also participated in inflammatory reaction in atherosclerosis. Elevated plasma concentrations of ADMA are also present in hypercholesterolemic and hypertensive patients, in patients with chronic heart failure, and in other patient groups at high risk of developing cardiovascular disease. Elevation of ADMA induces dysfunction of the endothelium, which becomes clinically evident by impaired endothelium-dependent vasodilation, hyperaggregability of platelets, and enhanced monocyte adhesion. Recent prospective studies suggest that endothelial dysfunction indicates an increased risk of future cardiovascular events. Most of scientifics found that ADMA is a novel cardiovascular risk factor. Plasma ADMA is now available as a routine laboratory evaluation

Keywords

Asymmetric dimethylarginine, Nitric oxide, Endothelial dysfunction

Asimetrik Dimetilarginin (ADMA)

Abstract

Asimetrik dimetilarginin (ADMA), esas olarak endojen nitrik oksit sentaz inhibitörüdür. ADMA, nitrik oksit oluşum hızını düzenler. Vasküler tonus ve yapısının sürdürülmesinde temel rolü oynadığına dair çok miktarda kanıt bulunmaktadır. ‘Endojen anti-aterosklerotik molekül’ olarak bilinen nitrik oksit, major endotel kaynaklı vazoaktif mediatörüdür. Dolayısıyla ADMA’nın endotel disfonksiyonu ile ilgili anahtar rolü oynayabileceği düşünülmektedir. Son zamanlarda, ADMA hiperkolesterolemili insanlar ve hayvanlarda önemli oranda yüksek bulunmuştur. ADMA aterosklerozun inflamatuvar reaksiyon sürecine de katılmaktadır. ADMA plazma konsantrasyonları olan hasta grubunda kronik kalp yetmezliği ve diğer kardiyovasküler hastalıkların yanısıra hiperkolesterolemili ve hipertansif hastalarda da artmaktadır. Bozulan endotel bağımlı vazodilatasyon, plateletlerin agregabilite artışı ve monosit adezyonu artışının klinik delili olarak ortaya çıkan endotel disfonksiyonu, ADMA artışını uyarır. Son prospektif çalışmalar, ortaya çıkabilecek kardiyovasküler olayların endotel disfonksiyonunu desteklemektedir. Birçok bilim adamı ADMA’yı yeni bir kardiyovasküler risk faktörü olarak düşünmektedir. Günümüzde plazma ADMA’nın rutin laboratuvarlarda ölçümü mümkündür

Keywords

Asimetrik dimetilarginin, Nitrik oksit, Endotel disfonksiyonu

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