A Case of Familial Mediterranean Fever Who Was Presented with Acute Coronary Syndrome

Year 2009, Volume: 11 Issue: 3, 39 - 41, 01.12.2009

Serkan Ordu Ahmet Kaya Mesut Aydın Gökhan Dindar Hakan Özhan Mehmet Yazıcı

Abstract

Familial Mediterranean fever is an autosomal recessive disease manifested by recurrent attacks of peritonitis, plevritis and arthritis, and characterized by clinical, histological and laboratory evidence for localized and systemic inflammation. Systemic inflammation is an important factor in the initiation and development of atherosclerosis. We report here a patient with long-standing FMF who was presented with acute coronary syndrome during the febrile attacks

Keywords

Familial Mediterranean fever, Acute Coronary Syndrome, Inflammation

Akut Koroner Sendrom ile Prezente Olan Ailesel Akdeniz Ateşi (FMF) Olgusu

Abstract

Ailesel Akdeniz Ateşi (FMF), klinik olarak tekrarlayan peritonit, plevrit ve artrit gibi seröz zar tutulumuyla karakterize, histolojik ve laboratuar bulgularıyla lokalize veya sistemik inflamasyon kanıtları olan, otozomal resesif geçiş gösteren genetik bir hastalıktır. Sistemik inflamasyon, ateroskleroz başlangıcı ve gelişimi açısından önemli bir faktördür. Biz burada uzun süredir FMF tanısıyla tedavi alan bir hastanın, febril atakları esnasında akut koroner sendrom gelişerek semptom verebileceğini gösterdik

Keywords

Ailesel Akdeniz Ateşi, Akut Koroner sendrom, İnflamasyon

References

• 1. Langevitz P, Livneh A, Neumann L, Buskila D, Shemer J, Amolsky D, Pras M. Prevalence of ischemic heart disease in patients with familial Mediterranean fever. Isr Med Assoc J. 3(1):9-12, 2001.
• 2. Uyarel H, Karabulut A, Ökmen Ö, Çam N. Familial Mediterranean fever and acute anterior myocardial infarction in a young patient. Anadol J Cardiol. 6:272- 274, 2006.
• 3. Akdogan A, Calguneri M, Yavuz B, Arslan EB, Kalyoncu U, Sahiner L, Karadag O, Ertenli I, Kiraz S, Aytemir K, Akata D, Tokgozoglu L, Oto A. Are familial Mediterranean fever (FMF) patients at increased risk for atherosclerosis? Impaired endothelial function and increased intima media thickness are found in FMF. J Am Coll Cardiol. 48(11):2351-2353, 2006.
• 4. Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB, Maseri A. The prognostic value of Creactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med. 331(7):417-424, 1994.
• 5. Peru H, Altun B, Doğan M, Kara F, Elmaci AM, Oran B. The evaluation of carotid intima-media thickness in children with familial Mediterranean fever. Clin Rheumatol (kabul tarihi: 23 Eylül 2007); (Basımda).
• 6. Onat AM, Oztürk MA, Ozçakar L, Ureten K, Kaymak SU, Kiraz S, Ertenli I, Calgüneri M. Selective serotonin reuptake inhibitors reduce the attack frequency in familial mediterranean fever. Tohoku J Exp Med. 211(1):9-14, 2007.