Drugs Induced Stevens-Johnson Syndrome

Year 2010, Volume: 12 Issue: 1, 98 - 103, 01.03.2010

Hülya Albayrak Zehra Gürlevik Yusuf Aydın Elif Önder

Abstract

Stevens Johnson Syndrome (SJS) is a life threatening mucocutaneous skin disease that mostlydeveloped after using some drug. SJS mostly appear between 2-4th decades. Mucocutaneouslesions were seen between 1-14 days of drug intake. And these lesions spread diffusely all aroundthe body. First treatment choice is the stopping of drug that cause SJS and giving supportingtreatment. After understanding of underlying cytotoxic and immunological mechanism of SJS,new treatment approaches were developed and mortality of disease was reduced. We hereinreport a short review of drug induced SJS and its treatment

Keywords

Stevens Johnson Syndrome, Drugs.

İlaçlara Bağlı Stevens-Johnson Sendromu

Abstract

Stevens Johnson Sendromu (SJS) sıklıkla ilaçlara bağlı olarak gelişen nadir fakat hayatı tehditedebilen mukokutanöz bir cilt reaksiyonudur. Her yaşta ortaya çıkabilmekle birlikte en sık 2–4. dekatlarda görülür. Mukokutanöz lezyonlar, sebep olan ilacın alınmasını takiben 1–14 günlükdöneminin ardından ortaya çıkar. Gövde ve yüzde başlayan eritematöz makülopapülerdöküntüler hızla tüm vücuda yayılır. Tedavisinde ilk basamak, sebep olan ilacın kesilmesi vedestek tedavisidir. Günümüzde altta yatan sitotoksik ve immünolojik mekanizmaların daha iyianlaşılması yeni tedavi yaklaşımlarının ortaya çıkmasını ve mortalitenin azalmasını sağlamıştır.Bu yazıda ilaçlara bağlı olarak gelişen SJS hakkında kısa bir derleme sunulmaktadır

Keywords

Stevens Johnson Sendromu, İlaçlar

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