The Relationship Between Lipid Levels And Bone Mineral Density in Postmenopausal Women

Year 2010, Volume: 12 Issue: 2, 30 - 35, 01.07.2010

Yalkın Çalık Selma Yazıcı Ersun Baş Safinaz Ataoglu

Abstract

Objective: The aim of this study is to investigate the relationship between lipid levels and bonemineral density in postmenopausal womenMethods: We studied 276 postmenopausal women aged 45- 65 years (mean 54 years) whoattended Duzce University faculty of medicine physical medicine and rehabilitation polyclinic.Bone mineral density in the lumbar spine and femur neck were measured by dual energy X-rayabsorptiometry. Serum cholesterol, lipoproteins and triglyceride were assessed on a bloodsample obtained after a 12-hour fast. All participants were given a questionnaire to answer onvarious risk factors for osteoporosis. Participants who reported the use of hormone replacementtherapy and lipid lowering therapy were excluded. Statistically significant associations werefound by SPSS 11.0 and p0,05)higher body mass index is associated with higher bone mineral density at femur neck and lumbarspine (both p values

Keywords

postmenopausal women, plasma lipid levels, bone mineral density

Postmenopozal Kadınlarda Lipid Düzeyleri Ve Kemik Mineral Yoğunluğu Arasındaki İlişki

Abstract

Amaç: Bu çalışmanın amacı postmenapozal kadınlarda lipid düzeyleri ile kemik mineral yoğunluğu arasındaki ilişkiyi araştırmaktır. Yöntem: Çalışmaya Düzce Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon AD. polikliniğine başvuran 45-65 yaşları arası (ortalama yaş 54) 276 postmenopozal kadın alındı. Lomber vertebra ve femur boynu kemik mineral yoğunlukları dual enerji X ray absorbsiyometre ile, 12 saat süren açlık sonrası alınan kan örneklerinden serum total kolesterol, lipoproteinler ve trigliserid ölçüldü Çalışmaya hormon replasman ve lipid düzeyi düşürücü tedavi alanlar dahil edilmedi. Çalışmaya alınan tüm kadınlara osteoporoz sorgulama formu dolduruldu. Bulgular: Serum lipoproteinleri, total kolesterol ve trigliserid ile femur boynu ve lomber vertebra kemik mineral yoğunlukları arasında anlamlılık bulunamadı (p>0,05). Yüksek vücut kitle indeksi ile femur boynu ve lomber vertebrada yüksek kemik mineral yoğunluğu istatistiksel olarak anlamlı bulundu (p

Keywords

postmenopozal kadın, plazma lipid düzeyleri, kemik mineral yoğunluğu

References

• Interim report and recommendations of the World Health Organization Task force for Osteoporosis. Osteoporosis Int 10:259-64,1999
• Rothman KJ, Greenland S: Modern Epidemiology, 2nd edition. Philadelphia, Pennsylvania. Lippincott Williams and Wilkins. 1998.
• Parhami F, Garfinkel A, Demer LL: Role of lipids in osteoporosis. Arterioscler Thromb Vasc Biol.20: 2346–8, 2000
• Demer LL, Perhami F:. Arterial calcification in face of osteoporosis in aging: can web lame oxidized lipids? Curr Opin Lipidol. 8:312-14, 1997
• Solomon DH, Avorn J, Canning CF, Wang PS: Lipid levels and bone mineral density. The Am. J Med.118:1414-18, 2005
• Riggs BL, Wahner HW, Dunn HW, Mazers RB, Offord KP, Melton LJ: Differential changes in bone mineral density of the appendicular and axial skeleton with aging. J Clin Invest. 67:328-35, 1981
• Majors AK, Boehm CA, Nitto H, Midura RJ, Muschler GF: Characterization of human bone marrow stromal cells with respect to osteoblastic differentiation. J Orthop Res. 15:546– 557, 1997
• Adami S, Braga V, Zamboni M, Gatti D, Rossini M, Bakri J: Relationship between lipids and bone mass in 2 cohorts of healty women and men. Calcif Tissue Int. 74:136-142, 2004
• Koshiyama H, Wada Y, Nakamura Y: Hypercholesterolemia as a possible risk factor for osteopeni in type 2 diabetes mellitus. Arch Intern Med.161:1678-79,2001
• Adami S, Braga V, Guidi G, Gatti D, Gerardi D, Fracassi E: Choronic intravenous aminobisphosphonate therapy increases high- density lipoprotein cholesterol and decreases low density lipoprotein cholesterol. J Bone Miner Res. 15:599-604, 2000
• Poli A, Bruschi F, Cesana B, Rossi M, Paoletti R, Crosignani PG: Plasma low-density lipoprotein cholesterol and bone mass densitometry in postmenopausal women. The American College of Obstr and Gynec.102: 922-26, 2003
• Zabaglia SF, Pedro AO, Pinto Neto AM, Guarisi T, Paiva LH, Lane E: An exploratory study of the associaton between lipid profile and bone mineral density in menopausal women in a Campinas reference hospital. Cad Saude Pub. 14:779-86, 2003
• D’Amelio P, Pescarmona GP, Gariboldi A, İsaia GC: High density lipoproteins (HDL) in women with postmenopausal osteoporosis: a preliminary study.Menopause. 8:429-32, 2003
• Recker R, Lappe J, Davies K, Heaney R: Characterization of perimenopausal bone loss: a prospective study. J Bone Miner Res.15:1965–73, 2003
• Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q et al: Plasma lipids and osteoporosis in postmenopausal women. Endocrine Journal. 49:211-7, 2002
• Broulik PD, Kapitola J: Interrelations between body weight, cigarette smoking and spine mineral density in osteoporotic Czech women. Endocr Regul. 27:57-60, 1993
• Tanko LB, Bagger YZ, Nielsen SB, Christiansen C: Does serum cholesterol contribute to vertebral bone loss in postmenopausal women. Bone. 32:8-14,2003
• Diascro Jr DD, Vogel RL, Johnson TE, Witherup KM, Pitzenberger SM, Rutledge SJ, Prescott DJ, Rodan GA, Schmidt A: High fatty acid content in rabbit serum is responsible fort he differentiation of the osteoblasts into adipocyte-like cells. J Bone Miner Res.13:96-106,1998
• Johnson CL, Rifkind BM, Sempos CT: Declining serum total cholesterol levels among US adults:The national health and Nutrition Examinations Survey. JAMA 269:3002-8,1993
• Orozco P, Hurtado I: High cholesterol levels are associated with low bone density in postmenopausal women. Osteoporosis Int. 11:103, 2000
• Cerrahoğlu L, Duruöz MT, Şenocak İ: Postmenopozal osteoporozda yüksek kolesterol düzeyi ile kemik mineral yoğunluğunun ilişkisi. Türk Fiz Reh Dergisi.12:23-27,2000
• Yamaguchi T, Sugimoto T, Yamauchi M, Sowa H, Chen Q, Chihara K. Plasma lipids and osteoporosis in postmenopausal women. Endocr J.49:211–7,2002
• Solomon DH, Avorn J, Canning CF, Wang PS: Lipids levels and bone mineral density. The American Journal of Medicine.118:1414-18,2002
• Cosman F, Nieves J, Walliser J, Lindsay R: Postmenopausal osteoporosis: patient choices and outcomes. Maturitas. 22:137–43,1995