Pain Reducing Effect Of Parenteral Paracetamol and Diclofenac After Septoplasty

Year 2010, Volume: 12 Issue: 2, 42 - 47, 01.07.2010

Selahattin Genç Umit Tuncel H Mete İnançlı Ayse Canan Yazıcı Abdurrahman Yurtaslan Damla Guclu Guven

Abstract

Objective: Intravenous (IV) paracetamol (acetaminophen) is an analgesic and antipyretic medication that can be used for reduction of postoperative pain. In this study, we compared the efficacies of IV paracetamol and intramuscular (IM) diclofenac on postoperative pain following septoplasty. Material and Method: In this study, 27 of 54 patients who had septoplasty were administered IV 1 gr paracetamol with six hours intervals (q.i.d.) after surgery while the other 27 patients received 75 mg diclofenac IM with 12 hours intervals (b.i.d.). Vital signs, electrocardiogram, and blood chemistry were obtained prior to administration of drugs and 24 hours postoperatively for detection of any possible side effects. Results: Both preparations were equally effective for controlling postoperative pain. There were no side effects in any of the groups. Statistical analysis did not reveal any difference between the groups (P > 0.05). Conclusion: Although there were no statistically significant differences between IV paracetamol and IM diclofenac for reduction of the postoperative pain, more frequent administration of paracetamol and 15 minute of infusion caused problems in early mobilization of patients when compared to diclofenac group. Total cost of the therapy was also in favor of diclofenac. Diclofenac was also cost-effective

Keywords

Acetaminophen, Diclofenac, Pain, Postoperative

Parenteral Parasetamol ve Diklofenakın Septoplasti Sonrası Ağrı Kesici Etkisi

Abstract

Amaç: IV acetaminophen (paracetamol) post-operatif olarak kullanılabilen analjezik ve antipiretik etkili bir preparattır. Bu çalışmada intravenöz parasetamolün ve intramüsküler olarak kullanılan diclofenak’ın postoperatif ağrılardaki etkinlikleri karşılaştırıldı. Materyal ve Metod: Bu çalışmada toplam 54 hastanın 27'sine 6 saat arayla 1gr IV paracetamol, 27'sine ise 12 saatte bir IM olarak diclofenak verildi. İlaç uygulamasından önce ve operasyondan 24 saat sonra oluşabilecek yan etkiler; vital bulgular, elektrokardiyografik (EKG) ve biyokimyasal olarak kontrol edildi. Bulgular: Her iki preparat da postoperatif ağrı kontrolünde oldukça etkiliydi. Gruplarda herhangi bir yan etki gözlenmedi. İstatistik analizler sonucunda gruplar arasında anlamlı bir fark görülmedi. Sonuç: İntravenöz uygulanan 1g paracetamol ile intramüsküler olarak uygulanan 75mg diclofenak arasında post operatif olarak ağrıyı azaltmadaki etkilerinde istatistiksel olarak anlamlı fark olmamasına rağmen parasetamolün her 6 saatte bir uygulanması ve uygulama sürecinin 15 dakika olması diclofenak grubu hastalarına göre erken mobilizasyonda sorun teşkil etmiştir. Ayrıca total maliyet hesaplandığında diclofenacın kulak burun boğaz ameliyatlarından sonra daha çok tercih edilebileceği düşüncesine varılmıştır.

Keywords

Parasetamol, Diklofenak, Postoperatif ağrı

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