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Efficacy Of Different Doses Palliative Radiotherapy On Painful Bone Metastases

Year 2010, Volume: 12 Issue: 2, 48 - 53, 01.07.2010

Abstract

Aim: to compare the efficacy of 1x8 gy, 5x4 gy, 10x3 gy doses of pallıatıve radıotherapy onpaınful bone metastases Method: In this study, 3 different dose fractionation irradiation schedules which consist of1x800 cgy, 5x400 cgy, 10x300 cgy have been evaluated in 25 patients with 29 painful bonemetastases, applied to radiation oncology department of çukurova university between february2002-september 2004.Results: 25 patients with 29 painful bone metastases were included in the study. Follow-upduration was 30 days. The age range was 28-74 with a mean age of 52. Eleven patients werefemale and 14 were male. At the end of the study, , no statistically significant difference wasdetected for pain palliation proportions (p=0.677) between study groups. Conclusion: the results of the present study were concordant with the previous studies, whichreported 70-80 % pain palliation. 1x800 cgy and 5x400 cgy therapy programs are preferable inpatients with poor life expectancy, poor general condition, and immobile and suitable anatomicallocalization

References

  • Martin M M , Thomas D F. Treatmant of metastatic cancer of bone.In:DeVita V T, Helman S, Rosenberg S A, Eds. Cancer, Principles and Practice of Oncology, Philadelphia: J.B. Lippincott Company, 2225-2246, 1993.
  • Scheid V, Buzdor A V , Smith T L , Hortobagyı G N. Clinical course of breast cancer patient with osseous metastases treated with combination chemotherapy. Cancer, 58:2589-2593, 1986.
  • Blitzer P H. Reanalysis of the RTOG study of the palliation of symtomatic osseous metastases. Cancer, 55: 1468-1472, 1985.
  • Chisholm G D, Rana A, Howard G C W. Management options for painful carcinoma of the prostat. Seminars in Oncology, 20:34-37, 1993.
  • Clavel M. Management of breast cancer with bone metastases. Bone, 12: 11-12, 1991.
  • Douglas P, Rossier P, Mirimanoff R-O, Coucke P A. Third-body irradiation as an effective palliative treatment for painful multipl bone metastases resistant to chemo or hormonal treatment. Radiotherapy and Oncology, 28: 76-78, 1993.
  • Epstein L M, Stewart B H, Antunez A R. Half and total body radiation for carcinoma of the prostat. The Journal of Urology 122: 330-332, 1979.
  • Lütolf U M, Huguenin P, Glanzmann C. Palliative radiotherapy of bone metastases.In: Diel I J Kaufmann M, Bastert G, Eds. Metastatic Bone Disease, Berlin: Springer-Verlag Limited, 127-133, 1994.
  • Hoskin P J. Radiotherapy in the management of bone metastases. In: Rubens R D, Fogelman I, Eds.Bone Metastases Diagnoses and Treatment, London: Springer-Verlag Limited, 171-185, 1991.
  • Gilbert H A , Kagan A R , Nussbaum H , Rao A R. Evaluation of radiation therapy for bone metastases: Pain relief and quality of life. Am J Roentgenol 129: 1095-1096 1977.
  • Price P ,Hoskin P J , Easton D. A prospective randomised trial of 4 Gy or 8 Gy single doses in the treatment of metastatic bone pain. Radiotherapy and Oncology, 23: 74-78, 1992.
  • Rasmusson B , Vejborg I, Jensen A B . Irradiation of bone metastases in breast cancer patients: a randomized study with l year follow up. Radiotherapy and Oncology, 34: 179-184, 1995.
  • Saad F, Gleason D M, Murray R. A randomized,placebo- controlled trial of zolendronic acid in patients with hormone-refractory metastatic prostate carcinoma. J Natl Cancer Inst, 94:1458-1468, 2002.
  • Hendrickson F R, Shehata W M, Kirchner A B. Radiotion therapy for osseous metastases. Int J Radiat Oncol Biol Phys, 1:275-278, 1976.
  • DeJong J M A. Radiotherapy for bone metastases. J Eur Radiother , 2: 123-126, 1981.
  • Vicky S J F, Buzdor A V, Smith T L, Hortobagy G N. Clinical Course of Breast Cancer Patients with Osseus Metastases Treated with Commination Chemotherapy. Cancer, 58: 2589- 2593, 1986.

Ağrılı Kemik Metastazlarında Farklı Dozlardaki Palyatif Radyoterapinin Ağrı Skoruna Etkisi

Year 2010, Volume: 12 Issue: 2, 48 - 53, 01.07.2010

Abstract

Amaç: Bu çalışmada 1x8 gy, 5x4 gy, 10x3 gy olarak üç değişik doz-fraksiyon şemasınarandomize edilen kemik metastazlı olguların sonuçları kendi aralarında ve literatürlekarşılaştırılarak kemik metastazlarının tedavisinde hangi ışınlama biçiminin daha avantajlıolduğunun belirlenmesine çalışılmıştırMetod: Bu çalışmada şubat 2002-eylül 2004 tarihleri arası çukurova üniversitesi radyasyononkolojisi bölümüne başvuran 29 ağrılı kemik metastazlı 25 hastada 1x800 cgy, 5x400 cgy ve10x300 cgy’ den oluşan 3 değişik doz- fraksiyon radyasyon şeması, palyatif etkilerini saptamakamacıyla değerlendirildi.Bulgular: Radyoterapi programına dahil edilen 25 hasta 29 farklı lokalizasyondan tedavigördü.takip süreleri 30 gündü. Yaşları 28-74 arasında değişim gösteren olgularda ortalama yaş52’ydi. Tedavi edilen 25 hastanın 11’i kadın, 14’ü erkekti. Çalışmanın sonunda çalışma gruplarıarasında ağrı palyasyon oranları için istatistiksel olarak anlamlı fark saptanmadı (p=0.677)Sonuç: Sonuçlar bugüne kadar yapılan çalışmalarda bildirilen %70-80 palyasyon oranı ileuyumludur. Ayrıca beklenen yaşam süresi kısa, genel durumu bozuk, immobil ve tedavi edilecekmetastatik bölgesi anatomik olarak uygun olan olgularda hastayı gereğinden fazla yormayacak,görevli personelin iş yükünü ve ekonomik maliyeti arttırmayacak kısa tedavi şemalarının (1x800cgy - 5x400 cgy) kullanılması uygundur

References

  • Martin M M , Thomas D F. Treatmant of metastatic cancer of bone.In:DeVita V T, Helman S, Rosenberg S A, Eds. Cancer, Principles and Practice of Oncology, Philadelphia: J.B. Lippincott Company, 2225-2246, 1993.
  • Scheid V, Buzdor A V , Smith T L , Hortobagyı G N. Clinical course of breast cancer patient with osseous metastases treated with combination chemotherapy. Cancer, 58:2589-2593, 1986.
  • Blitzer P H. Reanalysis of the RTOG study of the palliation of symtomatic osseous metastases. Cancer, 55: 1468-1472, 1985.
  • Chisholm G D, Rana A, Howard G C W. Management options for painful carcinoma of the prostat. Seminars in Oncology, 20:34-37, 1993.
  • Clavel M. Management of breast cancer with bone metastases. Bone, 12: 11-12, 1991.
  • Douglas P, Rossier P, Mirimanoff R-O, Coucke P A. Third-body irradiation as an effective palliative treatment for painful multipl bone metastases resistant to chemo or hormonal treatment. Radiotherapy and Oncology, 28: 76-78, 1993.
  • Epstein L M, Stewart B H, Antunez A R. Half and total body radiation for carcinoma of the prostat. The Journal of Urology 122: 330-332, 1979.
  • Lütolf U M, Huguenin P, Glanzmann C. Palliative radiotherapy of bone metastases.In: Diel I J Kaufmann M, Bastert G, Eds. Metastatic Bone Disease, Berlin: Springer-Verlag Limited, 127-133, 1994.
  • Hoskin P J. Radiotherapy in the management of bone metastases. In: Rubens R D, Fogelman I, Eds.Bone Metastases Diagnoses and Treatment, London: Springer-Verlag Limited, 171-185, 1991.
  • Gilbert H A , Kagan A R , Nussbaum H , Rao A R. Evaluation of radiation therapy for bone metastases: Pain relief and quality of life. Am J Roentgenol 129: 1095-1096 1977.
  • Price P ,Hoskin P J , Easton D. A prospective randomised trial of 4 Gy or 8 Gy single doses in the treatment of metastatic bone pain. Radiotherapy and Oncology, 23: 74-78, 1992.
  • Rasmusson B , Vejborg I, Jensen A B . Irradiation of bone metastases in breast cancer patients: a randomized study with l year follow up. Radiotherapy and Oncology, 34: 179-184, 1995.
  • Saad F, Gleason D M, Murray R. A randomized,placebo- controlled trial of zolendronic acid in patients with hormone-refractory metastatic prostate carcinoma. J Natl Cancer Inst, 94:1458-1468, 2002.
  • Hendrickson F R, Shehata W M, Kirchner A B. Radiotion therapy for osseous metastases. Int J Radiat Oncol Biol Phys, 1:275-278, 1976.
  • DeJong J M A. Radiotherapy for bone metastases. J Eur Radiother , 2: 123-126, 1981.
  • Vicky S J F, Buzdor A V, Smith T L, Hortobagy G N. Clinical Course of Breast Cancer Patients with Osseus Metastases Treated with Commination Chemotherapy. Cancer, 58: 2589- 2593, 1986.
There are 16 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Candaş Tunalı This is me

Zeki Akça This is me

Onkolojisi Bölümü Mersin This is me

Publication Date July 1, 2010
Published in Issue Year 2010 Volume: 12 Issue: 2

Cite

APA Tunalı, C., Akça, Z., & Mersin, O. B. (2010). Ağrılı Kemik Metastazlarında Farklı Dozlardaki Palyatif Radyoterapinin Ağrı Skoruna Etkisi. Duzce Medical Journal, 12(2), 48-53.
AMA Tunalı C, Akça Z, Mersin OB. Ağrılı Kemik Metastazlarında Farklı Dozlardaki Palyatif Radyoterapinin Ağrı Skoruna Etkisi. Duzce Med J. July 2010;12(2):48-53.
Chicago Tunalı, Candaş, Zeki Akça, and Onkolojisi Bölümü Mersin. “Ağrılı Kemik Metastazlarında Farklı Dozlardaki Palyatif Radyoterapinin Ağrı Skoruna Etkisi”. Duzce Medical Journal 12, no. 2 (July 2010): 48-53.
EndNote Tunalı C, Akça Z, Mersin OB (July 1, 2010) Ağrılı Kemik Metastazlarında Farklı Dozlardaki Palyatif Radyoterapinin Ağrı Skoruna Etkisi. Duzce Medical Journal 12 2 48–53.
IEEE C. Tunalı, Z. Akça, and O. B. Mersin, “Ağrılı Kemik Metastazlarında Farklı Dozlardaki Palyatif Radyoterapinin Ağrı Skoruna Etkisi”, Duzce Med J, vol. 12, no. 2, pp. 48–53, 2010.
ISNAD Tunalı, Candaş et al. “Ağrılı Kemik Metastazlarında Farklı Dozlardaki Palyatif Radyoterapinin Ağrı Skoruna Etkisi”. Duzce Medical Journal 12/2 (July 2010), 48-53.
JAMA Tunalı C, Akça Z, Mersin OB. Ağrılı Kemik Metastazlarında Farklı Dozlardaki Palyatif Radyoterapinin Ağrı Skoruna Etkisi. Duzce Med J. 2010;12:48–53.
MLA Tunalı, Candaş et al. “Ağrılı Kemik Metastazlarında Farklı Dozlardaki Palyatif Radyoterapinin Ağrı Skoruna Etkisi”. Duzce Medical Journal, vol. 12, no. 2, 2010, pp. 48-53.
Vancouver Tunalı C, Akça Z, Mersin OB. Ağrılı Kemik Metastazlarında Farklı Dozlardaki Palyatif Radyoterapinin Ağrı Skoruna Etkisi. Duzce Med J. 2010;12(2):48-53.