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The Effect of Short and Long Term Inhaler Corticosteroid Use on Oral and Periodontal Health in Asthmatic Patients

Year 2011, Volume: 13 Issue: 2, 16 - 22, 01.07.2011

Abstract

Purpose: The aim of this study was to investigate the clinical effects of the short and long terminhaler corticosteroid (ICS) use on oral and periodontal health in asthmatic patients.Methods: Control group was consisted of 17 subjects who had no systemic problems, whilethe study group consisted of 51 patients with asthma using ICS. Study groups were divided intothree subgroups in respect of the duration of ICS use. The clinical parameters such as PlaqueIndex (PI), Gingival Index (GI), Clinical attachment levels (CAL), Probing depth (PD), DMFT and salivary pH were recorded. Intraoral examination of patients was done for any mucosalpathology.Results: PI, GI, CAL, PD and salivary pH values of all subgroups of the study group were foundhigher than those of in control group (P

References

  • Practical Guide for the diagnosis and management of asthma. National Heart, Lung, and Blood Institues of Health. NIH Publication. 97-4053, 1997.
  • Yaghobee S, Paknejad M, Khorsand A: Association between Asthma and Periodontal disease. J Dent 5:47-51, 2008.
  • Talay F, Karabay O, Yılmaz F, Kocaoğlu E: Effect of inhaled budesonide on pharyngeal, gra- negative bacilli coloniztion in asthma patients. Respirology 12: 76-80, 2007.
  • Laurikainen K, Asthma and oral health, A clinical and epidemiological study, Tampere Universty Press Tampere, pp: 8-18, 2002.
  • Steinbacher DM, Glick M: The dental patient with asthma: An update and oral health consideration. JADA 132:1229-39, 2001.
  • Vries TW, Duierwan EJ, Puijenbroek LW: Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the Netherlands. Eur J Clin Pharmacol 62: 343- 6, 2006.
  • Matthew JD, Halpin DMG, Stein K: Inhaled ciclesonide versus inhaled budesonide or inhaled beclametasone or inhaled fluticasone for chronic asthma in adults: a systematic review. BMC Family Practice 7:1-12, 2006.
  • Lipworth BJ: Systemic adverse effects of inhaled corticosteroid therapy. A systematic review and meta-analysis. Arch Intern Med. 159:941-55, 1999.
  • Berkit IK, Turan Y, Sendur ÖF: Steroid induced osteoporosiz. Endocrinology 144:1761-9, 2003.
  • Don SD, Paul SF: Kronik obstrüktif akciğer hastalığında inhale steroidlerin tek başına veya bronkodilatör ile uzun süreli birlikte kullanımı yaşam süresini uzatırmı?, Current opinion in pulmpnary medicine. Türkçe Baskı 1:78-87, 2007.
  • Navarro BE, Corona HL, Fragaso RR, Berber A, Torres AS, Cuairan RV, Sienra MJJ: Effect of salmeterol and salmeterol plus beclometasone on saliva falow and IgA in patients with moderate-persistent choronic asthma. Ann Allergy Asthma Immunol. 87:420-3, 2001.
  • Sağ Ç, Özden FO, Açıkgöz G, Anlar FY: The effects of combination teratment with a long-acting B2 agonist and a corticosteroid on salivary flow rate, secretory ımmunoglobulin A, and oral health in children and adolescents with moderate asthma: a 1 mounth, single-blind clinical study. Clin Ther 29: 2236-42, 2007.
  • Karakoç GB, Altıntaş DU, Can S, Yılmaz M, Kendirli SG: Astımlı çocuklarda inhale budesonid ve flutikazon propiyonat kullanımının serum eozinofilik katyonik protein (ECP) üzerine etkisi. T Klin J Allergy-Asthma 3:1-5, 2001.
  • Don SD, Jack VT: Inhaled corticosteroids and the risk of mortality and readmission in elderly patients with choronic obstructive puılmonary disease. Am J Rest Crit Care Med 164: 580-4, 2001.
  • Shashıkıran ND, Reddy VVS: Krıshman RP.Effect of antiasthmatic medication on dental disease: Dental caries and periodontal disease. J.Indian Soc Pedod Prev Dent 65-68, 2007.
  • Hyyppa TM, Koivikko A, Paunio KU: Studies on periodontal conditions in asthmatic children, Acta Odontol Scand 37:15- 20, 1979.
  • Han ER, Choi IS, Kim HK, Kang YW, Park JG, Lim JR, Seo JH, Choi JH: Inhaled corticosteroid-related tooth problems in asthmatics. J Asthma 46:160-4, 2009.
  • Levin JA, Glick M: Dental management of patients with asthma. Compendium 17:284-92, 1996.
  • National Asthma Education and Preventive Program. Expert panel report 3: Guidelines for the diagnosis and management of asthma. NIH Publication Bethesda: National Institues of Health 07-4051, 2007.
  • Komerik N, Akaya A, Yıldız M, Büyükkaplan US, Kuru L: Oral health in patients on inhaled corticosteroid teratment, Oral Dis 11(5): 303-8, 2005.
  • Yiğit Ö, Taşkın Ü, Sunter A, Çakır ZA, Şişman A, Koçak İ, Uzman Ö: İnhaler steroid kullnımının ses üzerine etkilerinin ses analizi ile değerlendirlmesi. Turk Arc Otolaryngol 46:3, 2008.
  • Gallivan GJ, Gallivan KH: Inhaler corticosteroids: Hazardous effects on voice–an apdate. J Voice 21: 101-11, 2007.
  • Erdinç M, Öktem S, Kıran B, Veral A, Kokuludağ A: Astmada inhale steroid tedaviye yanıtın indükte balgam ECP düzeyi ile izlenmesi. Solunum 4:11-14, 2002.
  • Köksal N, Büyükbeşe NA, Çetinkaya A, İnanç F: Astımlılıarda inhaler kortikosteroid kullanımı glukoz tolerans bozukluğu yapıyormu? Dicle Tıp Dergisi 32: 26-30, 2005.
  • Shulman JD, Nunn ME, Taylor SE, Riverahidalgo F: The prevelance of periodontal-releated changes in adolescents with asthma: results of Third Annual National Health and Nutrition Examination Survey. Pediatr Dent 25: 279-84, 2003.
  • Derra EJ, Pollard MA, Curzon ME: The dental status of asthmatic British school children. Pediatr Dent 20: 281-7, 1998.
  • Locker D: Measuring social inequality in dental health services research: individual, househol and comminity based measures. Community Dent Health 10: 139-50, 1993.
  • Mandel ID, Eriv A, Kutscher A, Denning C, Thompson RH, Kessler W: Calcium and phosphours levels in submaxilllary saliva, Changes in cystic fibrosis and in asthma. Clin Pediatr (Phila) 8:161-4, 1969.
  • Kargul B, Tanboğa I, Ergeneli S, Karakoç F, Dağlı E: Inhaler medicament effects on saliva and plaque PH in asthmatic children. J Clin Pediatr Dent 22: 137-40, 1998.
  • Conolly ME, Greenacre JK: The Iymphcyte β adrenoceptor in normal subjects and patients with bronchial asthma. J Clin Invest 8:1307-16, 1976.
  • Ryberg M, Moller C, Ericson T: Effect of β2 adrenoceptor agonist on saliva proteins and dental caries in asthmatic children. J Dent Res 66:1404-6, 1987.
  • Bodur A: Osteoporoz: çene kemikleri ve periodontitis ile ilişkisi. GÜ Diş Hek Fak Derg. 21: 53-60, 2004.
  • Zhu J, Hidalgo HA, HolmgreeN WC, Redding SW, Hu J, Henry RJ: Dental management of chidren with asthma. Pediatr Dent 18:363-70, 1996.
  • Linder N, Kuint J, German B, Lubin D, Lowenthal R: Hypertrophy of the tongue associated with inhaled corticosteroid therapy in premature infants. J Pediatr 127: 651- 3, 1995.

Astımlı Hastalarda Kısa ve Uzun Dönem İnhaler Kortikosteroid Kullanımının Oral ve Periodontal Sağlık Üzerine Etkileri

Year 2011, Volume: 13 Issue: 2, 16 - 22, 01.07.2011

Abstract

Amaç: Bu çalışmanın amacı astımlı hastalarda kullanılan inhaler kortikosteroidlerin (İKS) kısave uzun dönemde oral ve periodontal sağlık üzerine etkilerini araştırmaktır.Yöntem: Çalışmamızda kontrol grubunu 17 sağlıklı birey, çalışma grubunu 51 astımlı ve İKSkullanan hastalar oluşturacak şekilde iki grup oluşturuldu. Çalışma grubu İKS kullanım süresinegöre üç alt gruba ayrıldı. Tüm bireylerden Plak İndeksi (Pİ), Gingival İndeks (Gİ), KlinikAtaşman Seviyesi (KAS), Sondlanan Cep Derinliği (SCD), DMF-T indeks ölçümü ve tükürükpH değeri ölçümü gerçekleştirildi. Hastaların ağız içi muayenelerinde mukozada patolojikdurum olup olmadığı incelendi.Bulgular: Pİ, Gİ, KAS, SCD ve tükürüğün pH’ı çalışma grubunun her üç alt grubunda ölçülenortalama değerleri kontrol grubunda ölçülen değerlerden anlamlı derecede yüksek bulundu(P

References

  • Practical Guide for the diagnosis and management of asthma. National Heart, Lung, and Blood Institues of Health. NIH Publication. 97-4053, 1997.
  • Yaghobee S, Paknejad M, Khorsand A: Association between Asthma and Periodontal disease. J Dent 5:47-51, 2008.
  • Talay F, Karabay O, Yılmaz F, Kocaoğlu E: Effect of inhaled budesonide on pharyngeal, gra- negative bacilli coloniztion in asthma patients. Respirology 12: 76-80, 2007.
  • Laurikainen K, Asthma and oral health, A clinical and epidemiological study, Tampere Universty Press Tampere, pp: 8-18, 2002.
  • Steinbacher DM, Glick M: The dental patient with asthma: An update and oral health consideration. JADA 132:1229-39, 2001.
  • Vries TW, Duierwan EJ, Puijenbroek LW: Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the Netherlands. Eur J Clin Pharmacol 62: 343- 6, 2006.
  • Matthew JD, Halpin DMG, Stein K: Inhaled ciclesonide versus inhaled budesonide or inhaled beclametasone or inhaled fluticasone for chronic asthma in adults: a systematic review. BMC Family Practice 7:1-12, 2006.
  • Lipworth BJ: Systemic adverse effects of inhaled corticosteroid therapy. A systematic review and meta-analysis. Arch Intern Med. 159:941-55, 1999.
  • Berkit IK, Turan Y, Sendur ÖF: Steroid induced osteoporosiz. Endocrinology 144:1761-9, 2003.
  • Don SD, Paul SF: Kronik obstrüktif akciğer hastalığında inhale steroidlerin tek başına veya bronkodilatör ile uzun süreli birlikte kullanımı yaşam süresini uzatırmı?, Current opinion in pulmpnary medicine. Türkçe Baskı 1:78-87, 2007.
  • Navarro BE, Corona HL, Fragaso RR, Berber A, Torres AS, Cuairan RV, Sienra MJJ: Effect of salmeterol and salmeterol plus beclometasone on saliva falow and IgA in patients with moderate-persistent choronic asthma. Ann Allergy Asthma Immunol. 87:420-3, 2001.
  • Sağ Ç, Özden FO, Açıkgöz G, Anlar FY: The effects of combination teratment with a long-acting B2 agonist and a corticosteroid on salivary flow rate, secretory ımmunoglobulin A, and oral health in children and adolescents with moderate asthma: a 1 mounth, single-blind clinical study. Clin Ther 29: 2236-42, 2007.
  • Karakoç GB, Altıntaş DU, Can S, Yılmaz M, Kendirli SG: Astımlı çocuklarda inhale budesonid ve flutikazon propiyonat kullanımının serum eozinofilik katyonik protein (ECP) üzerine etkisi. T Klin J Allergy-Asthma 3:1-5, 2001.
  • Don SD, Jack VT: Inhaled corticosteroids and the risk of mortality and readmission in elderly patients with choronic obstructive puılmonary disease. Am J Rest Crit Care Med 164: 580-4, 2001.
  • Shashıkıran ND, Reddy VVS: Krıshman RP.Effect of antiasthmatic medication on dental disease: Dental caries and periodontal disease. J.Indian Soc Pedod Prev Dent 65-68, 2007.
  • Hyyppa TM, Koivikko A, Paunio KU: Studies on periodontal conditions in asthmatic children, Acta Odontol Scand 37:15- 20, 1979.
  • Han ER, Choi IS, Kim HK, Kang YW, Park JG, Lim JR, Seo JH, Choi JH: Inhaled corticosteroid-related tooth problems in asthmatics. J Asthma 46:160-4, 2009.
  • Levin JA, Glick M: Dental management of patients with asthma. Compendium 17:284-92, 1996.
  • National Asthma Education and Preventive Program. Expert panel report 3: Guidelines for the diagnosis and management of asthma. NIH Publication Bethesda: National Institues of Health 07-4051, 2007.
  • Komerik N, Akaya A, Yıldız M, Büyükkaplan US, Kuru L: Oral health in patients on inhaled corticosteroid teratment, Oral Dis 11(5): 303-8, 2005.
  • Yiğit Ö, Taşkın Ü, Sunter A, Çakır ZA, Şişman A, Koçak İ, Uzman Ö: İnhaler steroid kullnımının ses üzerine etkilerinin ses analizi ile değerlendirlmesi. Turk Arc Otolaryngol 46:3, 2008.
  • Gallivan GJ, Gallivan KH: Inhaler corticosteroids: Hazardous effects on voice–an apdate. J Voice 21: 101-11, 2007.
  • Erdinç M, Öktem S, Kıran B, Veral A, Kokuludağ A: Astmada inhale steroid tedaviye yanıtın indükte balgam ECP düzeyi ile izlenmesi. Solunum 4:11-14, 2002.
  • Köksal N, Büyükbeşe NA, Çetinkaya A, İnanç F: Astımlılıarda inhaler kortikosteroid kullanımı glukoz tolerans bozukluğu yapıyormu? Dicle Tıp Dergisi 32: 26-30, 2005.
  • Shulman JD, Nunn ME, Taylor SE, Riverahidalgo F: The prevelance of periodontal-releated changes in adolescents with asthma: results of Third Annual National Health and Nutrition Examination Survey. Pediatr Dent 25: 279-84, 2003.
  • Derra EJ, Pollard MA, Curzon ME: The dental status of asthmatic British school children. Pediatr Dent 20: 281-7, 1998.
  • Locker D: Measuring social inequality in dental health services research: individual, househol and comminity based measures. Community Dent Health 10: 139-50, 1993.
  • Mandel ID, Eriv A, Kutscher A, Denning C, Thompson RH, Kessler W: Calcium and phosphours levels in submaxilllary saliva, Changes in cystic fibrosis and in asthma. Clin Pediatr (Phila) 8:161-4, 1969.
  • Kargul B, Tanboğa I, Ergeneli S, Karakoç F, Dağlı E: Inhaler medicament effects on saliva and plaque PH in asthmatic children. J Clin Pediatr Dent 22: 137-40, 1998.
  • Conolly ME, Greenacre JK: The Iymphcyte β adrenoceptor in normal subjects and patients with bronchial asthma. J Clin Invest 8:1307-16, 1976.
  • Ryberg M, Moller C, Ericson T: Effect of β2 adrenoceptor agonist on saliva proteins and dental caries in asthmatic children. J Dent Res 66:1404-6, 1987.
  • Bodur A: Osteoporoz: çene kemikleri ve periodontitis ile ilişkisi. GÜ Diş Hek Fak Derg. 21: 53-60, 2004.
  • Zhu J, Hidalgo HA, HolmgreeN WC, Redding SW, Hu J, Henry RJ: Dental management of chidren with asthma. Pediatr Dent 18:363-70, 1996.
  • Linder N, Kuint J, German B, Lubin D, Lowenthal R: Hypertrophy of the tongue associated with inhaled corticosteroid therapy in premature infants. J Pediatr 127: 651- 3, 1995.
There are 34 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

İsmet Bulut This is me

Serdar Berk This is me

Cenk Fatih Çanakçı This is me

Erkan Özcan This is me

Publication Date July 1, 2011
Published in Issue Year 2011 Volume: 13 Issue: 2

Cite

APA Bulut, İ., Berk, S., Çanakçı, C. F., Özcan, E. (2011). Astımlı Hastalarda Kısa ve Uzun Dönem İnhaler Kortikosteroid Kullanımının Oral ve Periodontal Sağlık Üzerine Etkileri. Duzce Medical Journal, 13(2), 16-22.
AMA Bulut İ, Berk S, Çanakçı CF, Özcan E. Astımlı Hastalarda Kısa ve Uzun Dönem İnhaler Kortikosteroid Kullanımının Oral ve Periodontal Sağlık Üzerine Etkileri. Duzce Med J. July 2011;13(2):16-22.
Chicago Bulut, İsmet, Serdar Berk, Cenk Fatih Çanakçı, and Erkan Özcan. “Astımlı Hastalarda Kısa Ve Uzun Dönem İnhaler Kortikosteroid Kullanımının Oral Ve Periodontal Sağlık Üzerine Etkileri”. Duzce Medical Journal 13, no. 2 (July 2011): 16-22.
EndNote Bulut İ, Berk S, Çanakçı CF, Özcan E (July 1, 2011) Astımlı Hastalarda Kısa ve Uzun Dönem İnhaler Kortikosteroid Kullanımının Oral ve Periodontal Sağlık Üzerine Etkileri. Duzce Medical Journal 13 2 16–22.
IEEE İ. Bulut, S. Berk, C. F. Çanakçı, and E. Özcan, “Astımlı Hastalarda Kısa ve Uzun Dönem İnhaler Kortikosteroid Kullanımının Oral ve Periodontal Sağlık Üzerine Etkileri”, Duzce Med J, vol. 13, no. 2, pp. 16–22, 2011.
ISNAD Bulut, İsmet et al. “Astımlı Hastalarda Kısa Ve Uzun Dönem İnhaler Kortikosteroid Kullanımının Oral Ve Periodontal Sağlık Üzerine Etkileri”. Duzce Medical Journal 13/2 (July 2011), 16-22.
JAMA Bulut İ, Berk S, Çanakçı CF, Özcan E. Astımlı Hastalarda Kısa ve Uzun Dönem İnhaler Kortikosteroid Kullanımının Oral ve Periodontal Sağlık Üzerine Etkileri. Duzce Med J. 2011;13:16–22.
MLA Bulut, İsmet et al. “Astımlı Hastalarda Kısa Ve Uzun Dönem İnhaler Kortikosteroid Kullanımının Oral Ve Periodontal Sağlık Üzerine Etkileri”. Duzce Medical Journal, vol. 13, no. 2, 2011, pp. 16-22.
Vancouver Bulut İ, Berk S, Çanakçı CF, Özcan E. Astımlı Hastalarda Kısa ve Uzun Dönem İnhaler Kortikosteroid Kullanımının Oral ve Periodontal Sağlık Üzerine Etkileri. Duzce Med J. 2011;13(2):16-22.