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The Effect of Plasma Ghrelin and Serum Leptin Levels on Growth in Breastfed and Formula-fed Infants during Early Infancy Period

Year 2011, Volume: 13 Issue: 3, 6 - 12, 01.12.2011

Abstract

Objective: To evaluate the effects of ghrelin, leptin and lipid levels on growth status of healthyinfants fed with breastmilk (BF) and formula (FF).Material and Metods: This study was performed in 46 healthy infants. The study group wassubdivided into two subgroups according to nutrition status as breastfed and formula infants.These infants were evaluated at two different times (mean of the second and fifth months,respectively). The ghrelin, leptin, triglyceride and total cholesterol levels of infants were studiedat the first visit.Results: Plasma total ghrelin concentrations were significantly higher in BF group than FFgroup(p

References

  • Dewey KG, Heinig MJ, Nommsen LA, Peerson JM, Lönnerdal B: Growth of breast-fed and formula-fed infants from 0 to 18 months: the. DARLING Study. Pediatrics. 89 :1035-1041, 1992
  • Agostini C, Grandi F, Gianni ML, Silano M, Torcoletti M, Giovannini M, Riva E: Growth patterns of breast fed and formula fed infants in the first 12 months of life: an Italian study. Arch Dis Child. 81:395-399, 1999
  • Nommsen-Rivers LA, Dewey KG: Growth of breastfed infants. Breastfeed Med. 4:45-49, 2009
  • Huh SY, Rifas-Shiman SL, Taveras EM, Oken E, Gillman MW: Timing of solid food introduction and risk of obesity in preschool-aged children. Pediatrics. 127:544-551, 2011
  • Li R, Fein SB, Grummer-Strawn LM: Do Infants Fed From Bottles Lack Self-regulation of Milk Intake Compared With Directly Breastfed Infants? Pediatrics. 125:1386-1393, 2010
  • Savino F, Fissore MF, Liguori SA, Oggero R: Can hormones contained in mothers' milk account for the beneficial effect of breast-feeding on obesity in children? Clin Endocrinol (Oxf). 71:757-765,2009
  • Bartok CJ, Ventura AK: Mechanisms underlying the association between breastfeeding and obesity. Int J Pediatr Obes. 4:196-204, 2009
  • Kojima M, Kangawa K: Structure and function of ghrelin. Results Probl Cell Differ. 46:89-115, 2008
  • Bluher S, Mantzoros CS: The role of leptin in regulating neuroendocrine function in humans. J Nutr. 134:2469-2474, 2004
  • Hosoda H, Doi K, Nagaya N, Okumura H, Nakagawa E, Enomoto M: Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples. Clin Chem. 50:1077-1180, 2004
  • Karatas Z, Durmus Aydogdu S, Dinleyici EC, Colak O, Dogruel N: Breastmilk ghrelin, leptin, and fat levels changing foremilk to hindmilk: is that important for self-control of feeding? Eur J Pediatr. 170:1273-80, 2011
  • Strauss R: Childhood obesity. Pediatr Clin North Am. 49:175- 201, 2002
  • Cavell B: Gastric emptying in infants fed human mil kor infant Formula. Acta Paediatr Scan. 70:639-641, 1981
  • Lucas A, Sarson Dl, Blackburn Am, Adrian TE, Aynsley-Green A, Bloom SR: Breast vs bottle: endocrine responses are different with formula feeding. Lancet. 1:1267-1269, 1980
  • Del Rincon JP, Thorner MO, Gaylinn BG: Motilin-related peptide and ghrelin: lessons from molecular techniques, peptide chemistry, and receptor biology. Gastroenterology. 120:587-588, 2001
  • Savino F, Grassino EC, Fissore MF, Guidi C, Liguori SA, Silvestro L: Ghrelin, motilin, insulin concentration in healthy infants in the first months of life: relation to fasting time and anthropometry. Clin Endocrinol (Oxf). 65:158-162, 2006
  • Gaige S, Abysique A, Bouvier M: Effects of leptin on cat intestinal motility. J Physiol. 546:267-277, 2003
  • Yiş U, Oztürk Y, Sişman AR, Uysal S, Soylu OB, Büyükgebiz B: The relation of serum ghrelin, leptin and insulin levels to the growth patterns and feeding characteristics in breast-fed versus formula-fed infants. Turk J Pediatr. 52:35-41, 2010
  • Savino F, Liguori SA, Fissore NF, Oggero R, Silvestro L, Miniero R: Serum Ghrelin Concentration and Wieght Gain in Heaalthy Term Infants in the First Year of Life. Journal Of Pediatric Gastroenterology and Nutrition. 41:653-659, 2005
  • Ng PC, Lee CH, Lam CW, Chan IH, Wong E, Fok TF: Ghrelin in preterm and term newborns: relation to anthropometry, leptin and insulin. Clin Endocrinol (Oxf). 63: 217-222, 2005
  • Camurdan MO, Bideci A, Demirel F, Cinaz P: Serum ghrelin, IGF-I and IGFBP-3 levels in children with normal variant short stature. Endocr J. 3:479-484, 2006
  • Fukishama N, Hanada R, Teranishi H, Fukue Y, Tachibana T, Ishikawa H:. Ghrelin directly regulates bone formation. J Bone Miner Res. 20:790-798, 2005
  • Petridou E, Mantzoros CS, Belechri M, Skalkidou A, Dessypris N, Papathoma E, Salvanos H, Lee JH, Kedikoglou S, Chrousos G, Trichopoulos D: Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf). 62:366- 371, 2005
  • Savino F, Liguori SA, Petrucci E, Lupica MM, Fissore MF, Oggero R, Silvestro L: Evaluation of leptin in breast milk, lactating mothers and their infants. Eur J Clin Nutr. 64:972- 977, 2010
  • Lönnerdal B, Havel PJ: Serum leptin concentrations in infants: effects of diet, sex and adiposity. Am J Clin Nutr. 72:484-489, 2000
  • Savino F, Costamagna M, Prino A, Oggero R, Silvestro L: Leptin levels in breast-fed and formula-fed infants. Acta Paediatr. 91:897-902, 2002
  • Savino F, Fissore MF, Grossino EC, Nanni GE, Oggero R, Silvestro L: Ghrelin, leptin and IGF-I levels in breast-fed and Formula-fed infants in the first years of life. Acta Pediatrica. 94:531-537, 2005
  • Lage M, Baldelli R, Camine JP, Rodriguez-Garci J, Penalva A, Dieguez C, Casanueva FF: Presence of bovine leptin in edible commercial milk and formula. J Endocrinol Invest. 25:670-674, 2002
  • O'Connor D, Funanage V, Locke R, Spear M, Leef K: Leptin is not present in infant formulas. J Endocrinol Invest. 26:490, 2003
  • Resto M, O’Connor D, Leef K, Funanage V, Spear M, Locke R: Leptin levels in preterm human breast milk and infant formula. Pediatrics. 108:15-18, 2001
  • Stocks RJ, Davies DP, Allen F, Sewell D: Loss of breast milk nutrients during tube feeding. Arch Dis Child. 60:164-166, 1985
  • Torsello A, Scibona B, Leo G, Bresciani E, Avallone R, Bulgarelli I, Luoni M, Zoli M, Rindi G, Cocchi D, Locatelli V: Ontogeny and tissue-spesific regulation of ghrelin mRNA expression suggest that ghrelin is primarly involved in the control of extraendocrine functions in the rat. Neuoroendocrinology. 77:91-99, 2003
  • Nishi Y, Hiejima H, Hosoda H, Kaiya H, Mori K, Fukue Y, Yanase T, Nawata H, Kangawa K, Kojima M: Ingested medium-chain fatty acids are directly utilized for the acyl- modification of ghrelin. Endocrinology. 146:2709-2715, 2005
  • Piao H, Hosoda H, Kangawa K, Murata T, Narita K, Higuchi T: Ghrelin stimulates milk intake by affecting adult type feeding behaviour in postnatal rats. J Neuroendocrinol. 20:330- 334, 2008
  • Leite E, Cowden EA, Friesen HG: Endocrinology of lactation and nursing: disorders of lactationn. In: DeGroot LJ, ed. Endocrinology. 224-238, 1995
  • Ravelli AC, van der Meulen JH, Osmond C, Barker DJ, Bleker OP: Infant feeding and adult glucose tolerance, lipid profile, blood pressure, and obesity. Arch Dis Child. 82:248-252, 2000
  • Reiser RB, O’Brien C, Henderson GR, Morroe RW: Studies on a possible function for cholesterol in milk. Nutr Rep Int. 19:835-849, 1979
  • Uauy R, Mize CE, Castillo-Duran C: Fat intake during childhood: metabolic responses and effects on growth. Am J Clin Nutr. 72:354-360, 2000
  • Demmers TA, Jones PJ, Wang Y, Krug S, Creutzinger V, Heubi JE: Effects of early cholesterol intake on cholesterol biosynthesis and plasma lipids among infants until 18 months of age. Pediatrics. 115:1594-1601, 2005

Erken Bebeklik Döneminde Anne Sütü ve Formül Mama ile Beslenen Bebeklerin Ghrelin ve Leptin Düzeylerinin Büyüme Üzerine Etkisi

Year 2011, Volume: 13 Issue: 3, 6 - 12, 01.12.2011

Abstract

Amaç: Anne sütü (AS) ve formül mama (FM) ile beslenen sağlıklı bebeklerde ghrelin, leptinve lipid düzeylerinin bebeklerin büyümesi üzerine etkilerini araştırmaktır.Gereç ve Yöntem: Kırk altı bebek beslenme şekillerine göre AS ve FM gruplarına ayrıldı veiki kez (ortalama iki ve beş aylıkken) değerlendirildi. İlk değerlendirmede ghrelin, leptin,trigliserid ve total kolesterol düzeyleri çalışıldı.Bulgular: AS grubunda plazma total ghrelin düzeyi FM grubundan anlamlı ölçüde yüksekbulundu (p

References

  • Dewey KG, Heinig MJ, Nommsen LA, Peerson JM, Lönnerdal B: Growth of breast-fed and formula-fed infants from 0 to 18 months: the. DARLING Study. Pediatrics. 89 :1035-1041, 1992
  • Agostini C, Grandi F, Gianni ML, Silano M, Torcoletti M, Giovannini M, Riva E: Growth patterns of breast fed and formula fed infants in the first 12 months of life: an Italian study. Arch Dis Child. 81:395-399, 1999
  • Nommsen-Rivers LA, Dewey KG: Growth of breastfed infants. Breastfeed Med. 4:45-49, 2009
  • Huh SY, Rifas-Shiman SL, Taveras EM, Oken E, Gillman MW: Timing of solid food introduction and risk of obesity in preschool-aged children. Pediatrics. 127:544-551, 2011
  • Li R, Fein SB, Grummer-Strawn LM: Do Infants Fed From Bottles Lack Self-regulation of Milk Intake Compared With Directly Breastfed Infants? Pediatrics. 125:1386-1393, 2010
  • Savino F, Fissore MF, Liguori SA, Oggero R: Can hormones contained in mothers' milk account for the beneficial effect of breast-feeding on obesity in children? Clin Endocrinol (Oxf). 71:757-765,2009
  • Bartok CJ, Ventura AK: Mechanisms underlying the association between breastfeeding and obesity. Int J Pediatr Obes. 4:196-204, 2009
  • Kojima M, Kangawa K: Structure and function of ghrelin. Results Probl Cell Differ. 46:89-115, 2008
  • Bluher S, Mantzoros CS: The role of leptin in regulating neuroendocrine function in humans. J Nutr. 134:2469-2474, 2004
  • Hosoda H, Doi K, Nagaya N, Okumura H, Nakagawa E, Enomoto M: Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples. Clin Chem. 50:1077-1180, 2004
  • Karatas Z, Durmus Aydogdu S, Dinleyici EC, Colak O, Dogruel N: Breastmilk ghrelin, leptin, and fat levels changing foremilk to hindmilk: is that important for self-control of feeding? Eur J Pediatr. 170:1273-80, 2011
  • Strauss R: Childhood obesity. Pediatr Clin North Am. 49:175- 201, 2002
  • Cavell B: Gastric emptying in infants fed human mil kor infant Formula. Acta Paediatr Scan. 70:639-641, 1981
  • Lucas A, Sarson Dl, Blackburn Am, Adrian TE, Aynsley-Green A, Bloom SR: Breast vs bottle: endocrine responses are different with formula feeding. Lancet. 1:1267-1269, 1980
  • Del Rincon JP, Thorner MO, Gaylinn BG: Motilin-related peptide and ghrelin: lessons from molecular techniques, peptide chemistry, and receptor biology. Gastroenterology. 120:587-588, 2001
  • Savino F, Grassino EC, Fissore MF, Guidi C, Liguori SA, Silvestro L: Ghrelin, motilin, insulin concentration in healthy infants in the first months of life: relation to fasting time and anthropometry. Clin Endocrinol (Oxf). 65:158-162, 2006
  • Gaige S, Abysique A, Bouvier M: Effects of leptin on cat intestinal motility. J Physiol. 546:267-277, 2003
  • Yiş U, Oztürk Y, Sişman AR, Uysal S, Soylu OB, Büyükgebiz B: The relation of serum ghrelin, leptin and insulin levels to the growth patterns and feeding characteristics in breast-fed versus formula-fed infants. Turk J Pediatr. 52:35-41, 2010
  • Savino F, Liguori SA, Fissore NF, Oggero R, Silvestro L, Miniero R: Serum Ghrelin Concentration and Wieght Gain in Heaalthy Term Infants in the First Year of Life. Journal Of Pediatric Gastroenterology and Nutrition. 41:653-659, 2005
  • Ng PC, Lee CH, Lam CW, Chan IH, Wong E, Fok TF: Ghrelin in preterm and term newborns: relation to anthropometry, leptin and insulin. Clin Endocrinol (Oxf). 63: 217-222, 2005
  • Camurdan MO, Bideci A, Demirel F, Cinaz P: Serum ghrelin, IGF-I and IGFBP-3 levels in children with normal variant short stature. Endocr J. 3:479-484, 2006
  • Fukishama N, Hanada R, Teranishi H, Fukue Y, Tachibana T, Ishikawa H:. Ghrelin directly regulates bone formation. J Bone Miner Res. 20:790-798, 2005
  • Petridou E, Mantzoros CS, Belechri M, Skalkidou A, Dessypris N, Papathoma E, Salvanos H, Lee JH, Kedikoglou S, Chrousos G, Trichopoulos D: Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf). 62:366- 371, 2005
  • Savino F, Liguori SA, Petrucci E, Lupica MM, Fissore MF, Oggero R, Silvestro L: Evaluation of leptin in breast milk, lactating mothers and their infants. Eur J Clin Nutr. 64:972- 977, 2010
  • Lönnerdal B, Havel PJ: Serum leptin concentrations in infants: effects of diet, sex and adiposity. Am J Clin Nutr. 72:484-489, 2000
  • Savino F, Costamagna M, Prino A, Oggero R, Silvestro L: Leptin levels in breast-fed and formula-fed infants. Acta Paediatr. 91:897-902, 2002
  • Savino F, Fissore MF, Grossino EC, Nanni GE, Oggero R, Silvestro L: Ghrelin, leptin and IGF-I levels in breast-fed and Formula-fed infants in the first years of life. Acta Pediatrica. 94:531-537, 2005
  • Lage M, Baldelli R, Camine JP, Rodriguez-Garci J, Penalva A, Dieguez C, Casanueva FF: Presence of bovine leptin in edible commercial milk and formula. J Endocrinol Invest. 25:670-674, 2002
  • O'Connor D, Funanage V, Locke R, Spear M, Leef K: Leptin is not present in infant formulas. J Endocrinol Invest. 26:490, 2003
  • Resto M, O’Connor D, Leef K, Funanage V, Spear M, Locke R: Leptin levels in preterm human breast milk and infant formula. Pediatrics. 108:15-18, 2001
  • Stocks RJ, Davies DP, Allen F, Sewell D: Loss of breast milk nutrients during tube feeding. Arch Dis Child. 60:164-166, 1985
  • Torsello A, Scibona B, Leo G, Bresciani E, Avallone R, Bulgarelli I, Luoni M, Zoli M, Rindi G, Cocchi D, Locatelli V: Ontogeny and tissue-spesific regulation of ghrelin mRNA expression suggest that ghrelin is primarly involved in the control of extraendocrine functions in the rat. Neuoroendocrinology. 77:91-99, 2003
  • Nishi Y, Hiejima H, Hosoda H, Kaiya H, Mori K, Fukue Y, Yanase T, Nawata H, Kangawa K, Kojima M: Ingested medium-chain fatty acids are directly utilized for the acyl- modification of ghrelin. Endocrinology. 146:2709-2715, 2005
  • Piao H, Hosoda H, Kangawa K, Murata T, Narita K, Higuchi T: Ghrelin stimulates milk intake by affecting adult type feeding behaviour in postnatal rats. J Neuroendocrinol. 20:330- 334, 2008
  • Leite E, Cowden EA, Friesen HG: Endocrinology of lactation and nursing: disorders of lactationn. In: DeGroot LJ, ed. Endocrinology. 224-238, 1995
  • Ravelli AC, van der Meulen JH, Osmond C, Barker DJ, Bleker OP: Infant feeding and adult glucose tolerance, lipid profile, blood pressure, and obesity. Arch Dis Child. 82:248-252, 2000
  • Reiser RB, O’Brien C, Henderson GR, Morroe RW: Studies on a possible function for cholesterol in milk. Nutr Rep Int. 19:835-849, 1979
  • Uauy R, Mize CE, Castillo-Duran C: Fat intake during childhood: metabolic responses and effects on growth. Am J Clin Nutr. 72:354-360, 2000
  • Demmers TA, Jones PJ, Wang Y, Krug S, Creutzinger V, Heubi JE: Effects of early cholesterol intake on cholesterol biosynthesis and plasma lipids among infants until 18 months of age. Pediatrics. 115:1594-1601, 2005
There are 39 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Zehra Karataş This is me

Sultan Durmuş Aydoğdu This is me

Banu Aydın This is me

Ahmet Karataş This is me

Publication Date December 1, 2011
Published in Issue Year 2011 Volume: 13 Issue: 3

Cite

APA Karataş, Z., Aydoğdu, S. D., Aydın, B., Karataş, A. (2011). Erken Bebeklik Döneminde Anne Sütü ve Formül Mama ile Beslenen Bebeklerin Ghrelin ve Leptin Düzeylerinin Büyüme Üzerine Etkisi. Duzce Medical Journal, 13(3), 6-12.
AMA Karataş Z, Aydoğdu SD, Aydın B, Karataş A. Erken Bebeklik Döneminde Anne Sütü ve Formül Mama ile Beslenen Bebeklerin Ghrelin ve Leptin Düzeylerinin Büyüme Üzerine Etkisi. Duzce Med J. December 2011;13(3):6-12.
Chicago Karataş, Zehra, Sultan Durmuş Aydoğdu, Banu Aydın, and Ahmet Karataş. “Erken Bebeklik Döneminde Anne Sütü Ve Formül Mama Ile Beslenen Bebeklerin Ghrelin Ve Leptin Düzeylerinin Büyüme Üzerine Etkisi”. Duzce Medical Journal 13, no. 3 (December 2011): 6-12.
EndNote Karataş Z, Aydoğdu SD, Aydın B, Karataş A (December 1, 2011) Erken Bebeklik Döneminde Anne Sütü ve Formül Mama ile Beslenen Bebeklerin Ghrelin ve Leptin Düzeylerinin Büyüme Üzerine Etkisi. Duzce Medical Journal 13 3 6–12.
IEEE Z. Karataş, S. D. Aydoğdu, B. Aydın, and A. Karataş, “Erken Bebeklik Döneminde Anne Sütü ve Formül Mama ile Beslenen Bebeklerin Ghrelin ve Leptin Düzeylerinin Büyüme Üzerine Etkisi”, Duzce Med J, vol. 13, no. 3, pp. 6–12, 2011.
ISNAD Karataş, Zehra et al. “Erken Bebeklik Döneminde Anne Sütü Ve Formül Mama Ile Beslenen Bebeklerin Ghrelin Ve Leptin Düzeylerinin Büyüme Üzerine Etkisi”. Duzce Medical Journal 13/3 (December 2011), 6-12.
JAMA Karataş Z, Aydoğdu SD, Aydın B, Karataş A. Erken Bebeklik Döneminde Anne Sütü ve Formül Mama ile Beslenen Bebeklerin Ghrelin ve Leptin Düzeylerinin Büyüme Üzerine Etkisi. Duzce Med J. 2011;13:6–12.
MLA Karataş, Zehra et al. “Erken Bebeklik Döneminde Anne Sütü Ve Formül Mama Ile Beslenen Bebeklerin Ghrelin Ve Leptin Düzeylerinin Büyüme Üzerine Etkisi”. Duzce Medical Journal, vol. 13, no. 3, 2011, pp. 6-12.
Vancouver Karataş Z, Aydoğdu SD, Aydın B, Karataş A. Erken Bebeklik Döneminde Anne Sütü ve Formül Mama ile Beslenen Bebeklerin Ghrelin ve Leptin Düzeylerinin Büyüme Üzerine Etkisi. Duzce Med J. 2011;13(3):6-12.