The Relation Between Hla-G And Cancer

Year 2012, Volume: 14 Issue: 2, 70 - 74, 01.07.2012

Ramazan Memişoğulları Taner Uçgun Hilmi Demirin M Engin Özcan

Abstract

The importance of HLA antigens on immunity and tissue compatibility is known. The suppressorrole of a non classical HLA antigen HLA-G is being clearer with the results of last studies. Onnormal situations its being is restricted in a few type of tissue. It can be found on fetal tissueslike trophoblasts, tymic medulla, cornea, pancreatic islets and precursors of erithroid andendothelial cells. The expression of HLA-g is increased in the situations like malignities,transplantation, multiple sclerosis, inflammatory diseases and viral infections. In this review itis aimed to give short information on HLA system and to introduce the studies pronouncing therelation of HLA-G and malignities

Keywords

HLA-G, cancer, tumor immunity

Hla-G Ve Kanser İlişkisi

Abstract

HLA antijenlerinin doku uyumu ve immünite açısından önemi bilinmektedir. HLA sınıf 1antijenlerinden non-klasik gruba dâhil olan HLA-G’nin kanser immunitesindeki baskılayıcı rolüson zamanlarda yapılan çalışmalarda daha da açığa çıkarılmıştır. HLA-G normal durumlardaçok kısıtlı dokularda bulunmaktadır. Trofoblastlar gibi fetal dokularda, timik medulla, kornea,pankreatik adacıklarda ve eritroid ve endotelial hücre prekürsörlerinde bulunmaktadır. HLA-Gekspresyonu bu fizyolojik durumların dışında kanserler, transplantasyon, multiple scleroz,inflamatuar hastalıklar ve viral enfeksiyonlar gibi patolojik durumlarda da artmış seviyelerdedir.Bu derlemede HLA sistemi hakkında kısaca bilgi verilerek HLA-G ile kanser ilişkisinivurgulayan farklı kanser türleri üzerinde yapılmış çalışmaları ortaya koymak amaçlanmıştır

Keywords

HLA-G, kanser, tumör immunitesi

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