Levels of Asymmetric Dimethylarginine (ADMA) and High Sensitive C-Reactive Protein (hsCRP) in Patients with Psoriasis

Year 2014, Volume: 16 Issue: 2, 23 - 26, 01.07.2014

Zehra Arslanyılmaz Serkan Bulur Ersoy Acer Esma Uslu Hülya Albayrak Yusuf Aslantaş Ramazan Memişoğulları Hakan Turan

Abstract

Aim: Asymmetric dimethylarginine (ADMA) is a major inhibitor of nitric oxide synthesis inhumans. Recent reports have demonstrated that elevated high sensitive C-reactive protein(hsCRP), an inflammatory marker, and plasma ADMA levels are associated with endothelialdysfunction and increased atherogenesis. We aimed to determine the presence of endothelialdysfunction in psoriatic patients and if psoriazis is an independent risk factor for cardiovasculardiseases by measuring the serum levels of ADMA and hsCRP in patients with psoriazis.Material and Methods: Thirty five psoriatic patients not having traditional cardiovascular riskfactors and 26 healthy controls were included into the study. Serum levels of ADMA, hsCRP,HDL, LDL, triglyceride, and total cholesterol, and BMI analyses were assessed and comparedbetween patient and control subjects. The association of psoriazis area and severity index (PASI)scores with ADMA and hsCRP levels were evaluated. Results: There was no statistically significant difference for the demographic characteristics,and all laboratory parameters levels between psoriazis and control groups. ADMA values were0.63±0.30 μmol/L (mean±sd) and 0.68±0.45 μmol/L (mean±sd) in patients and control group,respectively. hsCRP levels were 1.40±1.51 mg/L (mean±sd) in control group, while 1.91±2.13mg/L (mean±sd) in patients group. There was no statistically significant difference betweenpatients and control groups, in terms of ADMA and hsCRP values (p>0.05). Statisticallysignificance and moderate correlation was found between PASI scores and serum hsCRP levels(r=0,73; p

Keywords

asymmetric dimethylarginine, comorbidity, psoriazis, high sensitive C-reactive protein

PSORİAZİSLİ HASTALARDA SERUM ASİMETRİK DİMETİLARJİNİN (ADMA) VE YÜKSEK SENSİTİF C-REAKTİF PROTEİN (hsCRP) SEVİYELERİ

Abstract

Amaç: Asimetrik dimetilarjinin (ADMA) nitrik oksit sentezinin major inhibitörüdür. SerumADMA ve inflamatuar bir belirteç olan yüksek sensitif C reaktif protein (hsCRP) düzeylerindekiartışın endotel disfonksiyonu ve artmış aterogenez ile ilişkili olduğu gösterilmiştir. Bu çalışmadaplak psoriazis hastalarında ADMA ve hsCRP serum seviyelerini ölçerek hastalarda endotelyaldisfonksiyon varlığını belirlemeyi ve psoriazisin kendisinin kardiyovasküler hastalıklar içinbağımsız bir risk faktörü olup olmadığını tespit etmeyi amaçladık.Gereç ve Yöntem: Çalışmaya geleneksel kardiyovasküler risk faktörü taşımayan 35 psoriazislihasta ve 26 gönüllü kontrol dahil edildi. Hasta ve kontrol gruplarının serum ADMA, hsCRP,HDL, LDL, trigliserid, total kolesterol düzeyleri ve VKİ değerlendirildi ve karşılaştırıldı.Psoriazis alan şiddet indeksi (PAŞİ) skoru ile ADMA düzeyleri ve hsCRP arasındaki ilişkideğerlendirildi.Bulgular: Hasta ve kontrol grubu arasında demografik özellikler ve tüm laboratuvarparametrelerinin düzeyleri arasında istatistiksel anlamlı farklılık yoktu. ADMA değerleri hastagrubunda 0,63±0,30 μmol/L (ort±sd), kontrol grubunda ise 0,68±0,45 μmol/L (ort±sd) olaraktespit edildi. hsCRP düzeyleri hasta grubunda 1,91±2,13 mg/L (ort±sd) iken kontrol grubunda1,40±1,51 mg/L (ort±sd) idi. ADMA ve hsCRP değerleri açısından hasta ve kontrol grubuarasında istatistiksel olarak anlamlı bir farklılık bulunamadı (p>0,05). PAŞİ skorları ile hsCRPdüzeyleri arasında anlamlılık ve orta derecede pozitif korelasyon saptandı (r=0,73; p

Keywords

Asimetrik dimetilarjinin, komorbidite, psoriazis, yüksek sensitif C reaktifprotein

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