Assessment of Thyroid Disease in Patients Who Underwent Surgical Treatment of Primary Hyperparathyroidism

Year 2014, Volume: 16 Issue: 2, 27 - 30, 01.07.2014

Faruk Özkul Hüseyin Toman Gökhan Erbağ Mesut Erbaş İnan Anaforoğlu Hacer Şen Emine Binnetoğlu Fahri Güneş Kasım Arık Neslihan Bozkurt Mehmet Aşık

Abstract

Purpose: In this study we aimed to evaluate thyroid pathologies in patients with primaryhyperparathyroidism who underwent surgery for parathyroidectomy.Methods: Patients who underwent parathyroidectomy for primary hyperparathyroidism betweenthe years of 2006-2012 were included in this retrospective study. Before and after surgery,hormonal and biochemical examinations of the patients and results of preoperative imagingstudies were recorded.Results: Of the patients included in the study, 86 were female and 12 were male. Preoperativemean serum calcium level was 12.25 ± 1.48 mg/dL (normal range 8.5-10.1 mg/dL), meanparathyroid hormone (PTH) level was 425.09 ± 440.47 pg/mL (normal range 11-65 pg/mL).The thyroid ultrasound records of 93 patients were available. Of these patients, 26 (28%) hadnormal ultrasound, 18 (19.4%) had solitary nodule, 43 (46.2%) had multinodular goiter and 4(4.3%) had thyroiditis (without nodule) and 2 (% 2.2) had solitary nodule with thyroiditis.Adenoma was detected by ultrasonography in 45.2 % of patients, and by scintigraphy in 72.7of patients. Parathyroidectomy and thyroidectomy were performed at the same time in 54 of 98patients (65.1%). Of these patients Seven (7.1%) had papillary thyroid cancer, 30 (30.6%) hadbenign multinodular goiter, 8 patients (8.2%) had benign solitary nodule, 2 patients (2%) hadlymphocytic thyroiditis, and 7 (7.1%) had normal thyroid tissue.Conclusion: Thyroid diseases are frequently encountered with primary hyperparathyroidism.Therefore, before performing parathyroidectomy with minimally invasive procedure, patientsmust be evaluated for thyroid disorders

Keywords

Primary hyperparathyroidism, parathyroid surgery, thyroid carcinoma

PRİMER HİPERPARATİROİDİ NEDENİYLE OPERE EDİLEN VAKALARDA EŞLİK EDEN TİROİD PATOLOJİLERİNİN DEĞERLENDİRİLMESİ

Abstract

Amaç: Primer hiperparatiroidi (PHPT) nedeniyle paratirodektomi yapılan hastalarda eşlik edentiroid patolojilerinin değerlendirilmesi amaçlandı.Gereç ve Yöntem: Bu retrospektif çalışmaya 2006-2012 yılları arasında PHPT tanısı nedeniyleparatiroidektomi yapılan hastalar dahil edildi. Operasyon öncesi ve sonrası hastalarınbiyokimyasal ve hormonal tetkikleri, preoperatif görüntüleme tetkiklerinin sonuçları kaydedildi.Bulgular: Çalışmaya dahil edilen PHPT hastaların 86’sı kadın, 12’si erkekti. Hastalarınpreoperatif serum kalsiyumu ortalama 12.25 ± 1.48 mg/dL (8.5-10.1 mg/dL), paratiroit hormon(PTH) 425.09 ± 440.47 pg/mL (11-65 pg/mL) bulundu. Doksan sekiz hastanın 93’ünün tiroidultrason kayıtlarına ulaşıldı. Bu hastaların 26’sında (%28) tiroid ultrasonu normal, 18’inde(%19.4) soliter nodül, 43’ünde (%46.2) multinodüler guatr, 4’ünde (%4.3) tiroidit (nodülsüz),2’sinde (%2.2) soliter nodül ve tiroidit görünümü birlikte tespit edildi. Genel olarak hastaların%72’sinde tiroid patolojisi mevcuttu. Hastaların %45.2’sinde ultrasonda ve %72.7’sindeparatiroit sintigrafisinde paratiroit adenomu tespit edildi. Doksan sekiz hastanın 54’üne (%65.1)paratiroidektomi ile birlikte tiroidektomi de yapıldı. Yedi (%7.1) hastada papiller tiroid kanseri,30 hastada (%30.6) benign multinodüler guatr, 8 hastada (%8.2) benign soliter nodül, 2 hastada(%2) lenfositik tiroidit ve 7 hastada (%7.1) normal tiroid dokusu tespit edildi. Sonuç: Tiroid hastalıklarının PHPT ile birlikteliği sık görülebilmektedir. Bu nedenleparatiroidektominin minimal invaziv yöntemle yapılmasına karar vermeden önce hastalarmutlaka tiroid patolojisi açısından değerlendirilmelidir

Keywords

Primer hiperparatiroidi, paratiroidektomi, tiroid kanseri

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