Year 2019, Volume 21 , Issue 2, Pages 72 - 78 2019-08-30

Obstrüktif Uyku Apneli Hastalarda Metabolik Sendrom İçin Göğüs Radyografisi Üzerinde Güçlü Bir İpucu: Aortik Ark Kalsifikasyonu
A Strong Clue on Chest Radiography for Metabolic Syndrome in Patients with Obstructive Sleep Apnea: Aortic Arch Calcification

Adem ADAR [1] , Orhan ÖNALAN [2] , Hasan CASİM [3] , Fahri ÇAKAN [4] , Ugur KÖKTÜRK [5] , Erdem ÇETİN [6] , Emre ÖZÇALIK [7]


Amaç: Obstrüktif uyku apnesi (OSA), ateroskleroz ve metabolik sendrom (MetS) gelişimi için önemli bir risk faktörüdür. Vasküler kalsifikasyon ateroskleroz gelişiminde önemli bir rol oynamaktadır. Buna rağmen, literatürde MetS ile vasküler kalsifikasyon arasındaki ilişkiyi gösteren veriler yetersizdir. Bu çalışmanın amacı, OSA'lı hastalarda MetS ile aortik ark kalsifikasyonu arasındaki ilişkiyi araştırmaktır.

Gereç ve Yöntemler: Bir gece polisomnografi laboratuvarında yatan ve OSA tanısı koyulan hastalar çalışmaya dahil edildi. Hastalar MetS varlığına göre iki gruba ayrıldı. Polisomnografik değerlendirme sonuçlarından habersiz olan iki araştırmacı akciğer grafilerini inceledi.

Bulgular: Çalışmaya OSA tanısı alan toplam 314 hasta dahil edildi. Hastaların %33,1 kadın ve ortalama yaş 51,2±10,9 idi. Çalışmaya alınan hastaların %43,6'sında hafif OSA, %30,9'unda orta derecede OSA ve %25,5'inde ağır OSA varlığı saptandı. Hastaların %56,4'ünde (n=177) aortik ark kalsifikasyonu, %58,6'sında (n=184) ise MetS saptandı. Aortik ark kalsifikasyonu prevalansının MetS saptanan hastalarda MetS saptanamayan hastalara göre daha yüksek olduğu bulundu (p<0,001). Çoklu lojistik regresyon analizinde, vücut kitle indeksinin (1,148; %95 GA 1,089-1,210), apne hipopne indeksinin (1,039; %95 GA, 1,016-1,062) ve aortik ark kalsifikasyonunun (4,986; 95% GA 2,887-8,610) MetS varlığı için bağımsız prediktörler olduğu bulundu.

Sonuç: OSA'lı hastalarda akciğer grafisinde görülebilen aortik ark kalsifikasyonu ile MetS arasında güçlü bir ilişki olduğu bulundu. Aortik ark kalsifikasyonu, OSA'lı hastalarda MetS gelişimi ile ilgili klinisyenler için uyarıcı bir bulgu olabilir.

Aim: Obstructive sleep apnea (OSA) is associated with increased atherosclerosis and metabolic syndrome (MetS). Vascular calcification plays a pivotal role in the development of atherosclerosis. However, data regarding vascular calcification and MetS is insufficient. The aim of the present study was to investigate the association between MetS and aortic arch calcification in patients with OSA.

Material and Methods: Patients who underwent an overnight polysomnography and diagnosed with OSA were enrolled into the study. Patients were classified into two groups based on the presence of MetS. Two examiners who were unaware of the results of polysomnographic assessment reviewed the chest radiograms.

Results: A total of 314 patients with OSA were included in the study. 33.1% of the patients were female and mean age was 51.2±10.9. Of these, 43.6% had mild OSA, 30.9% had moderate OSA, and 25.5% had severe OSA. Aortic arch calcification was detected in 56.4% (n=177) and MetS was detected in 58.6% (n=184) of the patients. Prevalence of aortic arch calcification was higher in patients with MetS than in those without MetS (p<0.001). By multiple logistic regression analysis found that body mass index (1.148, 95% CI, 1.089-1.210), apnea hypnea index (1.039, 95% CI, 1.016-1.062), and aortic arch calcification (4.986, 95% CI, 2.887-8.610) were found to be predictors of MetS.

Conclusion: Aortic arch calcification seen in chest radiography is strongly associated with MetS in patients with OSA. Aortic arch calcification may be an alerting finding for clinicians regarding the development of MetS in patients with OSA.

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Primary Language en
Subjects Medicine
Journal Section Research Article
Authors

Orcid: 0000-0002-2404-6447
Author: Adem ADAR (Primary Author)
Institution: Karabuk University Faculty of Medicine Department of Cardiology
Country: Turkey


Orcid: 0000-0001-9780-7051
Author: Orhan ÖNALAN
Institution: Karabuk University Faculty of Medicine Department of Cardiology
Country: Turkey


Orcid: 0000-0002-3952-8385
Author: Hasan CASİM
Institution: Karabuk University Faculty of Medicine Department of Chest
Country: Turkey


Orcid: 0000-0002-5427-3480
Author: Fahri ÇAKAN
Institution: Karabuk University Faculty of Medicine Department of Cardiology
Country: Turkey


Orcid: 0000-0003-0459-9295
Author: Ugur KÖKTÜRK
Institution: Karabuk University Faculty of Medicine Department of Cardiology
Country: Turkey


Orcid: 0000-0002-4065-9016
Author: Erdem ÇETİN
Institution: Karabuk University Faculty of Medicine Department of Cardiovascular Surgery
Country: Turkey


Orcid: 0000-0002-5324-9796
Author: Emre ÖZÇALIK
Institution: Karabuk University Faculty of Medicine Department of Cardiology
Country: Turkey


Dates

Publication Date : August 30, 2019

Bibtex @research article { dtfd534927, journal = {Duzce Medical Journal}, issn = {}, eissn = {1307-671X}, address = {}, publisher = {Duzce University}, year = {2019}, volume = {21}, pages = {72 - 78}, doi = {10.18678/dtfd.534927}, title = {A Strong Clue on Chest Radiography for Metabolic Syndrome in Patients with Obstructive Sleep Apnea: Aortic Arch Calcification}, key = {cite}, author = {Adar, Adem and Önalan, Orhan and Casi̇m, Hasan and Çakan, Fahri and Köktürk, Ugur and Çeti̇n, Erdem and Özçalık, Emre} }
APA Adar, A , Önalan, O , Casi̇m, H , Çakan, F , Köktürk, U , Çeti̇n, E , Özçalık, E . (2019). A Strong Clue on Chest Radiography for Metabolic Syndrome in Patients with Obstructive Sleep Apnea: Aortic Arch Calcification . Duzce Medical Journal , 21 (2) , 72-78 . DOI: 10.18678/dtfd.534927
MLA Adar, A , Önalan, O , Casi̇m, H , Çakan, F , Köktürk, U , Çeti̇n, E , Özçalık, E . "A Strong Clue on Chest Radiography for Metabolic Syndrome in Patients with Obstructive Sleep Apnea: Aortic Arch Calcification" . Duzce Medical Journal 21 (2019 ): 72-78 <https://dergipark.org.tr/en/pub/dtfd/issue/48404/534927>
Chicago Adar, A , Önalan, O , Casi̇m, H , Çakan, F , Köktürk, U , Çeti̇n, E , Özçalık, E . "A Strong Clue on Chest Radiography for Metabolic Syndrome in Patients with Obstructive Sleep Apnea: Aortic Arch Calcification". Duzce Medical Journal 21 (2019 ): 72-78
RIS TY - JOUR T1 - A Strong Clue on Chest Radiography for Metabolic Syndrome in Patients with Obstructive Sleep Apnea: Aortic Arch Calcification AU - Adem Adar , Orhan Önalan , Hasan Casi̇m , Fahri Çakan , Ugur Köktürk , Erdem Çeti̇n , Emre Özçalık Y1 - 2019 PY - 2019 N1 - doi: 10.18678/dtfd.534927 DO - 10.18678/dtfd.534927 T2 - Duzce Medical Journal JF - Journal JO - JOR SP - 72 EP - 78 VL - 21 IS - 2 SN - -1307-671X M3 - doi: 10.18678/dtfd.534927 UR - https://doi.org/10.18678/dtfd.534927 Y2 - 2019 ER -
EndNote %0 Düzce Tıp Fakültesi Dergisi A Strong Clue on Chest Radiography for Metabolic Syndrome in Patients with Obstructive Sleep Apnea: Aortic Arch Calcification %A Adem Adar , Orhan Önalan , Hasan Casi̇m , Fahri Çakan , Ugur Köktürk , Erdem Çeti̇n , Emre Özçalık %T A Strong Clue on Chest Radiography for Metabolic Syndrome in Patients with Obstructive Sleep Apnea: Aortic Arch Calcification %D 2019 %J Duzce Medical Journal %P -1307-671X %V 21 %N 2 %R doi: 10.18678/dtfd.534927 %U 10.18678/dtfd.534927
ISNAD Adar, Adem , Önalan, Orhan , Casi̇m, Hasan , Çakan, Fahri , Köktürk, Ugur , Çeti̇n, Erdem , Özçalık, Emre . "A Strong Clue on Chest Radiography for Metabolic Syndrome in Patients with Obstructive Sleep Apnea: Aortic Arch Calcification". Duzce Medical Journal 21 / 2 (August 2019): 72-78 . https://doi.org/10.18678/dtfd.534927
AMA Adar A , Önalan O , Casi̇m H , Çakan F , Köktürk U , Çeti̇n E , Özçalık E . A Strong Clue on Chest Radiography for Metabolic Syndrome in Patients with Obstructive Sleep Apnea: Aortic Arch Calcification. Duzce Medical Journal. 2019; 21(2): 72-78.
Vancouver Adar A , Önalan O , Casi̇m H , Çakan F , Köktürk U , Çeti̇n E , Özçalık E . A Strong Clue on Chest Radiography for Metabolic Syndrome in Patients with Obstructive Sleep Apnea: Aortic Arch Calcification. Duzce Medical Journal. 2019; 21(2): 72-78.