Ketiapine Bağlı İnterstisyel Akciğer Hastalığı: Olgu Sunumu ve Literatür İncelemesi

Year 2020, Volume: 22 Issue: 2, 140 - 142, 30.08.2020

Müge Topcuoğlu Ali Erdoğan

https://doi.org/10.18678/dtfd.732586

Cited By: 1

Abstract

Ketiapin yaygın kullanılan, baş dönmesi, sedasyon ve metabolik yan etkiler gibi birçok yaygın yan etkisi olan bir antipsikotik ilaçtır. Bunlara ek olarak, ilacın bazı nadir yan etkileri de mevcuttur. Bunlar arasında ilaca bağlı interstisyel akciğer hastalığı (drug-induced interstitial lung disease, DI-ILD) çok az bilinmektedir. Bu olgu sunumunda ketiapin kullanımının akciğer yan etkilerini tartışmayı amaçladık. Elli dört yaşında erkek bir şizofreni hastasında ketiapin kullanımını takiben ortaya çıkan, nadir görülen bir yan etki olan interstisyel akciğer hastalığı olgusu sunulmaktadır. Olgumuzda, ketiapin tedavisinin başlamasından sonra ortaya çıkan ve ketiapin kesildikten sonra gerileyen akciğer bulguları nedeniyle DI-ILD düşünülmüştür. Klinisyenler, ketiapin kullanımının bir sonucu olarak ortaya çıkabilecek DI-ILD gibi nadir akciğer yan etkileri konusunda dikkatli olmalıdır.

Keywords

Interstisyel akciğer hastalığı, ketiapin, şizofreni

Interstitial Lung Disease due to Quetiapine: Case Report and Literature Review

Abstract

Quetiapine is a commonly used antipsychotic drug which has many common side effects such as dizziness, sedation, and metabolic side effects. In addition to them, the drug has also some rare side effects. Among them, little is known about drug-induced interstitial lung disease (DI-ILD). In this case report, we aimed to discuss the side effects of quetiapine use on the lung. We present a case of interstitial lung disease, which is rare side effect, that occurred following quetiapine use in a 54-year-old male schizophrenia patient. In our case, DI-ILD was examined due to the lung findings that occurred after quetiapine treatment started and regressed after quetiapine cessation. Clinicians should be careful about rare lung side effects such as DI-ILD that may develop as a result of quetiapine use.

Keywords

interstitial lung disease, quetiapine, schizophrenia

References

• Devlin JW, Roberts RJ, Fong JJ, Skrobik Y, Riker RR, Hill NS, et al. Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, double-blind, placebo-controlled pilot study. Crit Care Med. 2010;38(2):419-27.
• Eyer F, Pfab R, Felgenhauer N, Strubel T, Saugel B, Zilker T. Clinical and analytical features of severe suicidal quetiapine overdoses--a retrospective cohort study. Clin Toxicol (Phila). 2011;49(9):846-53.
• Can KC, Karnak D, Özgüven HD. A very rare adverse effect of clozapine, clozapine-induced interstitial lung disease: Case report and literature review. Noro Psikiyatr Ars. 2019;56(4):313-5.
• Chen XF, Peng SC, Li J, Wei LQ, Zhang YH. Interstitial lung disease caused by psychiatric drug therapy. Int J Clin Exp Pathol. 2016;9(2):1706-12.
• Kim SJ, Han SD, Lee JY, Chon GR. A case of drug-induced interstitial pneumonia potentially related to quetiapine (seroquel) therapy for behavioral and psychological symptoms. Respir Care. 2014;59(10):e145-8.
• Wessels LE, Wallace JD, Calvo RY, Levko T, Bowie JM, Butler WJ, et al. Quetiapine therapy in critically injured trauma patients is associated with an increased risk of pulmonary complications. Am J Surg. 2020;219(5):804-9.
• Matsuno O. Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respir Res. 2012;13(1):39.
• Popper HH. Interstitial lung diseases-can pathologists arrive at an etiology-based diagnosis? A critical update. Virchows Arch. 2013;462(1):1-26.
• Wijnen PA, Bekers O, Drent M. Relationship between drug-induced interstitial lung diseases and cytochrome P450 polymorphisms. Curr Opin Pulm Med. 2010;16(5):496-502.