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Evaluation of the Relationship between Serum 25-Hydroxyvitamin D Levels and Pulmonary Functions in Adult Asthma

Year 2020, Volume: 22 Issue: 3, 185 - 190, 30.12.2020
https://doi.org/10.18678/dtfd.777282

Abstract

Aim: This study was aimed to determine the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and the pulmonary functions in adult asthma patients.
Material and Methods: A total of 131 asthmatic patients’ general characteristics, asthma symptoms, pulmonary function test, asthma control test (ACT) scores, serum 25(OH)D levels, body weight, and height were recorded. Body mass indexes (BMIs) of the patients were calculated and World Health Organization criteria were used for the classification. Patients with serum 25(OH)D levels below 20 ng/mL were classified as having a deficiency, those with 21-29 ng/mL as having an insufficiency, and those with 30 ng/mL and above as having normal serum vitamin D levels.
Results: The serum 25(OH)D levels of patients in the uncontrolled asthma group, according to the ACT score, were found to be lower than those of patients in the controlled group (p=0.002). It was determined that as the serum 25(OH)D levels of the patients increased, the ACT scores also increased significantly (r=0.280, p=0.001). Additionally it was found that each 1 ng/mL increase in 25(OH)D level was associated with an increase of 0.176 L in forced vital capacity (FVC). In addition it was determined that as the serum 25(OH)D levels increased, the patients’ FVCs also increased (OR=1.056, 95% CI=1.003-1.113, p=0.038). Although the change was not statistically significant (p=0.081), as serum 25(OH)D levels increased, the ACT scores also increased.
Conclusion: Vitamin D insufficiency and deficiency were frequently found in adults with asthma and there was a relationship between vitamin D deficiency and pulmonary function.

References

  • Türk Toraks Derneği. Astım Tanı ve Tedavi Rehberi Güncellemesi. Turk Thorac J. 2016;17(Suppl 1):1-96.
  • GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1211-59.
  • Girum T, Mesfin D, Bedewi J, Shewangizaw M. The burden of noncommunicable diseases in Ethiopia, 2000-2016: analysis of evidence from Global Burden of Disease Study 2016 and Global Health Estimates 2016. Int J Chronic Dis. 2020;2020:3679528.
  • Wöbke TK, Sorg BL, Steinhilber D. Vitamin D in inflammatory diseases. Front Physiol. 2014;5:244.
  • Maalmi H, Berraïes A, Tangour E, Ammar J, Abid H, Hamzaoui K, et al. The impact of vitamin D deficiency on immune T cells in asthmatic children: a case-control study. J Asthma Allergy. 2012;5:11-9.
  • Hughes DA, Norton R. Vitamin D and respiratory health. Clin Exp Immunol. 2009;158(1):20-5.
  • Paul G, Brehm JM, Alcorn JF, Holguín F, Aujla SJ, Celedón JC. Vitamin D and asthma. Am J Respir Crit Care Med. 2012;185(2):124-32.
  • Ginde AA, Mansbach JM, Camargo CA Jr. Vitamin D, respiratory infections, and asthma. Curr Allergy Asthm R. 2009;9(1):81-7.
  • Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol. 2010;126(1):52-8.
  • Esfandiar N, Alaei F, Fallah S, Babaie D, Sedghi N. Vitamin D deficiency and its impact on asthma severity in asthmatic children. Ital J Pediatr. 2016;42(1):108.
  • Korn S, Hübner M, Jung M, Blettner M, Buhl R. Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res. 2013;14(1):25.
  • Köksal E, Küçükerdönmez Ö. Şişmanlığı saptamada güncel yaklaşımlar. In: Baysal A, Baş M, editors. Yetişkinlerde ağırlık yönetimi. İstanbul: Ekspress Baskı; 2008. p.35-70.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30.
  • Uysal MA, Mungan D, Yorgancioglu A, Yildiz F, Akgun M, Gemicioglu B, et al. The validation of the Turkish version of asthma control test. Qual Life Res. 2013;22(7):1773-9.
  • Rajabbik MH, Lotfi T, Alkhaled L, Fares M, El-Hajj Fuleihan G, Mroueh S, et al. Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies. Allergy Asthma Clin Immunol. 2014;10(1):31.
  • Turkeli A, Ayaz O, Uncu A, Ozhan B, Bas VN, Tufan AK, et al. Effects of vitamin D levels on asthma control and severity in pre-school children. Eur Rev Med Pharmacol Sci. 2016;20(1):26-36.
  • Uysalol M, Mutlu LC, Varol Saracoglu G, Karasu E, Guzel S, Kayaoglu S, et al. Childhood asthma and vitamin D deficiency in Turkey: is there cause and effect relationship between them? Ital J Pediatr. 2013;39:78.
  • Li F, Peng M, Jiang L, Sun Q, Zhang K, Lian F, et al. Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. Respiration. 2011;81(6):469-75.
  • Beyhan-Sagmen S, Baykan O, Balcan B, Ceyhan B. Association between severe vitamin D deficiency, lung function and asthma control. Arch Bronconeumol. 2017;53(4):186-91.
  • Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med. 2010;181(7):699-704.
  • Montero-Arias F, Sedó-Mejía G, Ramos-Esquivel A. Vitamin D insufficiency and asthma severity in adults from Costa Rica. Allergy Asthma Immunol Res. 2013;5(5):283-8.
  • Larose TL, Langhammer A, Chen Y, Camargo Jr CA, Romundstad P, Mai XM. Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study. Eur Respir J. 2015;45(4):1019-26.
  • Özbey Ü, Uçar A. Current factors related with asthma process: obesity and nutrition. GUJHS. 2018;7(2):70-7.
  • Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012;33(3):456-92.
  • Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113(1):59-65.
  • Brehm JM, Acosta-Pérez E, Klei L, Roeder K, Barmada M, Boutaoui N, et al. Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children. Am J Respir Crit Care Med. 2012;186(2):140-6.
  • Gupta A, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, et al. Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med. 2011;184(12):1342-9.
  • Columbo M, Panettieri RA Jr, Rohr AS. Asthma in the elderly: a study of the role of vitamin D. Allergy Asthma Clin Immunol. 2014;10(1):1-5.
  • Worth H, Stammen D, Keck E. Therapy of steroid-induced bone loss in adult asthmatics with calcium, vitamin D, and a diphosphonate. Am J Respir Crit Care Med. 1994;150(2):394-7.
  • Martineau AR, MacLaughlin BD, Hooper RL, Barnes NC, Jolliffe DA, Greiller CL, et al. Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs). Thorax. 2015;70(5):451-7.
  • Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014;311(20):2083-91.
  • de Groot JC, van Roon EN, Storm H, Veeger NJ, Zwinderman AH, Hiemstra PS, et al. Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma. J Allergy Clin Immunol. 2015;135(3):670-5.

Serum 25-Hidroksivitamin D Düzeylerinin Yetişkin Astım Hastalarında Pulmoner Fonksiyonlar ile İlişkisinin Değerlendirilmesi

Year 2020, Volume: 22 Issue: 3, 185 - 190, 30.12.2020
https://doi.org/10.18678/dtfd.777282

Abstract

Amaç: Bu çalışmanın amacı, yetişkin astım hastalarında serum 25-hidroksivitamin D [25(OH)D] düzeyleri ile pulmoner fonksiyonlar arasındaki ilişkiyi saptamaktır.
Gereç ve Yöntemler: Toplam 131 astım hastasının genel özellikleri, astım semptomları, solunum fonksiyon testi, astım kontrol testi (AKT) skorları, serum 25(OH)D seviyeleri, vücut ağırlığı ve boy uzunluğu verileri kayıt altına alınmıştır. Hastaların beden kütle indeksleri (BKİ) hesaplanmış ve sınıflandırma için Dünya Sağlık Örgütü kriterleri kullanılmıştır. Serum 25(OH)D seviyesi 20 ng/mL'nin altında olan bireyler D vitamini eksikliği, 21-29 ng/mL olanlar D vitamini yetersizliği ve 30 ng/mL ve üstü olanlar ise normal serum D vitamini düzeyi olarak sınıflandırılmıştır.
Bulgular: AKT skoruna göre kontrolsüz astım grubundaki bireylerin serum 25(OH)D düzeyleri, kontrollü gruptaki bireylerden daha düşük bulunmuştur (p=0,002). Bireylerin serum 25(OH)D düzeyleri arttıkça AKT skorlarının da anlamlı şekilde arttığı saptanmıştır (r=0,280; p=0,001). Buna ek olarak serum 25(OH)D seviyesindeki her 1 ng/mL'lik artışın zorlu vital kapasite (forced vital capacity, FVC)’de 0.176 L'lik bir artış ile ilişkili olduğu bulunmuştur. Ayrıca serum 25(OH)D seviyeleri arttıkça, bireylerin FVC düzeylerinin de arttığı tespit edilmiştir (OR=1,056; %95 GA=1,003-1,113; p=0,038). İstatistiksel olarak önemli olmamakla birlikte (p=0,081), serum 25(OH)D seviyeleri arttıkça AKT skorlarının da arttığı belirlenmiştir.
Sonuç: Astım hastası olan yetişkinlerde D vitamini yetersizliği ve eksikliğinin sık görüldüğü ve D vitamini eksikliği ile solunum fonksiyonu arasında bir ilişki olduğu belirlenmiştir.

References

  • Türk Toraks Derneği. Astım Tanı ve Tedavi Rehberi Güncellemesi. Turk Thorac J. 2016;17(Suppl 1):1-96.
  • GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1211-59.
  • Girum T, Mesfin D, Bedewi J, Shewangizaw M. The burden of noncommunicable diseases in Ethiopia, 2000-2016: analysis of evidence from Global Burden of Disease Study 2016 and Global Health Estimates 2016. Int J Chronic Dis. 2020;2020:3679528.
  • Wöbke TK, Sorg BL, Steinhilber D. Vitamin D in inflammatory diseases. Front Physiol. 2014;5:244.
  • Maalmi H, Berraïes A, Tangour E, Ammar J, Abid H, Hamzaoui K, et al. The impact of vitamin D deficiency on immune T cells in asthmatic children: a case-control study. J Asthma Allergy. 2012;5:11-9.
  • Hughes DA, Norton R. Vitamin D and respiratory health. Clin Exp Immunol. 2009;158(1):20-5.
  • Paul G, Brehm JM, Alcorn JF, Holguín F, Aujla SJ, Celedón JC. Vitamin D and asthma. Am J Respir Crit Care Med. 2012;185(2):124-32.
  • Ginde AA, Mansbach JM, Camargo CA Jr. Vitamin D, respiratory infections, and asthma. Curr Allergy Asthm R. 2009;9(1):81-7.
  • Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol. 2010;126(1):52-8.
  • Esfandiar N, Alaei F, Fallah S, Babaie D, Sedghi N. Vitamin D deficiency and its impact on asthma severity in asthmatic children. Ital J Pediatr. 2016;42(1):108.
  • Korn S, Hübner M, Jung M, Blettner M, Buhl R. Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res. 2013;14(1):25.
  • Köksal E, Küçükerdönmez Ö. Şişmanlığı saptamada güncel yaklaşımlar. In: Baysal A, Baş M, editors. Yetişkinlerde ağırlık yönetimi. İstanbul: Ekspress Baskı; 2008. p.35-70.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30.
  • Uysal MA, Mungan D, Yorgancioglu A, Yildiz F, Akgun M, Gemicioglu B, et al. The validation of the Turkish version of asthma control test. Qual Life Res. 2013;22(7):1773-9.
  • Rajabbik MH, Lotfi T, Alkhaled L, Fares M, El-Hajj Fuleihan G, Mroueh S, et al. Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies. Allergy Asthma Clin Immunol. 2014;10(1):31.
  • Turkeli A, Ayaz O, Uncu A, Ozhan B, Bas VN, Tufan AK, et al. Effects of vitamin D levels on asthma control and severity in pre-school children. Eur Rev Med Pharmacol Sci. 2016;20(1):26-36.
  • Uysalol M, Mutlu LC, Varol Saracoglu G, Karasu E, Guzel S, Kayaoglu S, et al. Childhood asthma and vitamin D deficiency in Turkey: is there cause and effect relationship between them? Ital J Pediatr. 2013;39:78.
  • Li F, Peng M, Jiang L, Sun Q, Zhang K, Lian F, et al. Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. Respiration. 2011;81(6):469-75.
  • Beyhan-Sagmen S, Baykan O, Balcan B, Ceyhan B. Association between severe vitamin D deficiency, lung function and asthma control. Arch Bronconeumol. 2017;53(4):186-91.
  • Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med. 2010;181(7):699-704.
  • Montero-Arias F, Sedó-Mejía G, Ramos-Esquivel A. Vitamin D insufficiency and asthma severity in adults from Costa Rica. Allergy Asthma Immunol Res. 2013;5(5):283-8.
  • Larose TL, Langhammer A, Chen Y, Camargo Jr CA, Romundstad P, Mai XM. Serum 25-hydroxyvitamin D levels and lung function in adults with asthma: the HUNT Study. Eur Respir J. 2015;45(4):1019-26.
  • Özbey Ü, Uçar A. Current factors related with asthma process: obesity and nutrition. GUJHS. 2018;7(2):70-7.
  • Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012;33(3):456-92.
  • Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113(1):59-65.
  • Brehm JM, Acosta-Pérez E, Klei L, Roeder K, Barmada M, Boutaoui N, et al. Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children. Am J Respir Crit Care Med. 2012;186(2):140-6.
  • Gupta A, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, et al. Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med. 2011;184(12):1342-9.
  • Columbo M, Panettieri RA Jr, Rohr AS. Asthma in the elderly: a study of the role of vitamin D. Allergy Asthma Clin Immunol. 2014;10(1):1-5.
  • Worth H, Stammen D, Keck E. Therapy of steroid-induced bone loss in adult asthmatics with calcium, vitamin D, and a diphosphonate. Am J Respir Crit Care Med. 1994;150(2):394-7.
  • Martineau AR, MacLaughlin BD, Hooper RL, Barnes NC, Jolliffe DA, Greiller CL, et al. Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs). Thorax. 2015;70(5):451-7.
  • Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014;311(20):2083-91.
  • de Groot JC, van Roon EN, Storm H, Veeger NJ, Zwinderman AH, Hiemstra PS, et al. Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma. J Allergy Clin Immunol. 2015;135(3):670-5.
There are 32 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

Olgun Keskin This is me 0000-0002-0995-7680

Nilgün Seremet Kürklü 0000-0003-1394-0037

Publication Date December 30, 2020
Submission Date August 6, 2020
Published in Issue Year 2020 Volume: 22 Issue: 3

Cite

APA Keskin, O., & Seremet Kürklü, N. (2020). Evaluation of the Relationship between Serum 25-Hydroxyvitamin D Levels and Pulmonary Functions in Adult Asthma. Duzce Medical Journal, 22(3), 185-190. https://doi.org/10.18678/dtfd.777282
AMA Keskin O, Seremet Kürklü N. Evaluation of the Relationship between Serum 25-Hydroxyvitamin D Levels and Pulmonary Functions in Adult Asthma. Duzce Med J. December 2020;22(3):185-190. doi:10.18678/dtfd.777282
Chicago Keskin, Olgun, and Nilgün Seremet Kürklü. “Evaluation of the Relationship Between Serum 25-Hydroxyvitamin D Levels and Pulmonary Functions in Adult Asthma”. Duzce Medical Journal 22, no. 3 (December 2020): 185-90. https://doi.org/10.18678/dtfd.777282.
EndNote Keskin O, Seremet Kürklü N (December 1, 2020) Evaluation of the Relationship between Serum 25-Hydroxyvitamin D Levels and Pulmonary Functions in Adult Asthma. Duzce Medical Journal 22 3 185–190.
IEEE O. Keskin and N. Seremet Kürklü, “Evaluation of the Relationship between Serum 25-Hydroxyvitamin D Levels and Pulmonary Functions in Adult Asthma”, Duzce Med J, vol. 22, no. 3, pp. 185–190, 2020, doi: 10.18678/dtfd.777282.
ISNAD Keskin, Olgun - Seremet Kürklü, Nilgün. “Evaluation of the Relationship Between Serum 25-Hydroxyvitamin D Levels and Pulmonary Functions in Adult Asthma”. Duzce Medical Journal 22/3 (December 2020), 185-190. https://doi.org/10.18678/dtfd.777282.
JAMA Keskin O, Seremet Kürklü N. Evaluation of the Relationship between Serum 25-Hydroxyvitamin D Levels and Pulmonary Functions in Adult Asthma. Duzce Med J. 2020;22:185–190.
MLA Keskin, Olgun and Nilgün Seremet Kürklü. “Evaluation of the Relationship Between Serum 25-Hydroxyvitamin D Levels and Pulmonary Functions in Adult Asthma”. Duzce Medical Journal, vol. 22, no. 3, 2020, pp. 185-90, doi:10.18678/dtfd.777282.
Vancouver Keskin O, Seremet Kürklü N. Evaluation of the Relationship between Serum 25-Hydroxyvitamin D Levels and Pulmonary Functions in Adult Asthma. Duzce Med J. 2020;22(3):185-90.