COVID-19 Aşısı Geliştirme Süreci Üzerine Bir Değerlendirme
A Review of the Progress of COVID-19 Vaccine Development

Sami ULLAH [1] , Abdullah Ghodran AL-SEHEMI [2] , Jiří Jaromír KLEMEŠ [3] , Sanam SAQIB [4] , Sahibzada Muhammad Azib GONDAL [5] , Sidra SAQIB [6] , Akasha ARSHAD [7] , Hira SAQIB [8] , Ahmad MUKHTAR [9] , Muhammad IBRAHIM [10] , Saira ASIF [11] , Awais BOKHARI [12]


Koronavirüs hastalığı (coronavirus disease 2019, COVID-19) pandemisi, şiddetli akut solunum yolu sendromu koronavirüsü 2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)’nin neden olduğu ve henüz hastalığın olumsuz etkilerinin azalmasına yönelik yeterli kanıtın bulunmadığı küresel bir sorundur. Güvenilir bir aşı stratejisinin geliştirilmesiyle normal yaşama dönüleceğine dair genel bir fikir birliği oluşmuştur. Birçok ülke, COVID-19’a karşı etkin tedavi geliştirmek için klinik araştırma sürecini hızlandırmıştır. SARS-CoV-2 için 200'den fazla aday aşı test edilmeye başlanmıştır. Bu çalışmada, güncel COVID-19 aşı türleri genel olarak gözden geçirilecek, COVID-19 aşılarının teorik ve pratik zorlukları incelenecek ve aşı tasarımının başarılı olmasına yardımcı olacak olası stratejiler tartışılacaktır. Çalışmanın ilk bölümünde, anahtar kelimeler olarak “pandemiler, aşılar ve aşı türleri” kullanılarak literatürde yer alan makaleler incelenmiştir. Scopus veritabanında başlangıç anahtar kelimeleri ile toplam 63.538 sonuç (1.200 dergi, 16.875 kitap ve 12.871 web sayfası) incelenmiştir. Daha sonra "pandemi ve aşı türleri" gibi anahtar kelimeler ile daha ayrıntılı arama yapılmıştır (711 gazete ve 5.053 web sayfası). Bu çalışmada ayrıca, pandemilerle ilgili tarihsel arka plan, virolojik özellikleri, yapısı, kökeni ve fizyo-kimyasal özellikleri de incelenmiştir. İkinci bölümde, aşılama türleri ve stratejileri derinlemesine araştırılmıştır. Bu bölümde, SARS-CoV-2 ve SARS-COV-2/COVID-19 aşılarının teşhisi, virolojisi ve patogenezi üzerinde durulmuştur. COVID-19 aşılarının geliştirilmesi, planlama stratejileri, türleri, maliyeti ve güncel senaryoları ayrıntılı olarak açıklanmıştır. COVID-19 pandemisi var olduğu sürece küresel bir sorun olmaya devam edecektir. Aşılama, bu salgını hafifletmek ve kontrol altına almak için etkili ve ekonomik bir yol olarak görünmektedir. Bu hedefe ulaşmak için, etkin COVID-19 aşılarının seri üretimi en başarılı yol olacaktır.
A coronavirus disease pandemic (COVID-19) is still a global problem with not sufficient evidence of a declining pattern caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is generally accepted that normal life is impeded by securing a reliable vaccine strategy. Many countries have accelerated the process of clinical trials to create effective treatment with COVID-19. More than 200 candidate vaccines have been started for SARS-CoV-2 testing. This review attempts to provide an overview of the currently emerging COVID-19 vaccine types, address the theoretical and practical challenges of vaccines for COVID-19 and discuss possible strategies to help vaccine design succeed. The first move was to take out papers using the initial keyword “pandemics, vaccines and vaccine types”. A total of 63,538 results (including 1,200 journals; 16,875 books; and 12,871 web pages), with the initial keyword, searched for in the Scopus database. Further improvements were searched on keywords such as "pandemic and vaccine types" (711 newspapers and 5,053 webpages). This review attempts to overview the historical and important basic information about the pandemics viz. history, virological characteristics, structure, origin and physio-chemical properties. The second phase includes the vaccination types and strategies in depth. It includes the diagnosis, virology and pathogenesis of SARS-CoV-2 and SARS-COV-2/COVID-19 vaccines. The development, planning strategies, types, cost and current scenarios of COVID-19 vaccines are depicted in detail. The pandemic COVID-19 as it continues, is a global problem. Vaccination seems to be an efficient and economical way to mitigate and control the epidemic. This requires a mass production of successful COVID-19 vaccines.
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Primary Language en
Subjects Medicine
Journal Section Invited Review
Authors

Orcid: 0000-0002-9669-5737
Author: Sami ULLAH
Institution: King Khalid University
Country: Saudi Arabia


Orcid: 0000-0002-6793-3038
Author: Abdullah Ghodran AL-SEHEMI
Institution: King Khalid University
Country: Saudi Arabia


Orcid: 0000-0002-7450-7029
Author: Jiří Jaromír KLEMEŠ (Primary Author)
Institution: Brno University of Technology
Country: Czech Republic


Orcid: 0000-0002-4026-660X
Author: Sanam SAQIB
Institution: Rawalpindi Medical University
Country: Pakistan


Orcid: 0000-0002-4065-5066
Author: Sahibzada Muhammad Azib GONDAL
Institution: Fauji Foundation Hospital
Country: Pakistan


Orcid: 0000-0003-2325-2393
Author: Sidra SAQIB
Institution: COMSATS University Islamabad
Country: Pakistan


Orcid: 0000-0001-9864-6034
Author: Akasha ARSHAD
Institution: Red Crescent Medical and Dental College
Country: Pakistan


Orcid: 0000-0002-7938-3555
Author: Hira SAQIB
Institution: University of Education
Country: Pakistan


Orcid: 0000-0003-3367-5963
Author: Ahmad MUKHTAR
Institution: NFC Institute of Engineering and Fertilizer Research
Country: Pakistan


Orcid: 0000-0003-4624-1849
Author: Muhammad IBRAHIM
Institution: Government College University Faisalabad
Country: Pakistan


Orcid: 0000-0001-8185-0653
Author: Saira ASIF
Institution: PMAS Arid Agriculture University
Country: Pakistan


Orcid: 0000-0002-0748-6336
Author: Awais BOKHARI
Institution: Brno University of Technology
Country: Czech Republic


Dates

Publication Date : March 30, 2021

Bibtex @review { dtfd890089, journal = {Duzce Medical Journal}, issn = {}, eissn = {1307-671X}, address = {}, publisher = {Duzce University}, year = {2021}, volume = {23}, pages = {1 - 23}, doi = {10.18678/dtfd.890089}, title = {A Review of the Progress of COVID-19 Vaccine Development}, key = {cite}, author = {Ullah, Sami and Al-sehemı, Abdullah Ghodran and Klemeš, Jiří Jaromír and Saqıb, Sanam and Gondal, Sahibzada Muhammad Azib and Saqıb, Sidra and Arshad, Akasha and Saqıb, Hira and Mukhtar, Ahmad and Ibrahım, Muhammad and Asıf, Saira and Bokharı, Awais} }
APA Ullah, S , Al-sehemı, A , Klemeš, J , Saqıb, S , Gondal, S , Saqıb, S , Arshad, A , Saqıb, H , Mukhtar, A , Ibrahım, M , Asıf, S , Bokharı, A . (2021). A Review of the Progress of COVID-19 Vaccine Development . Duzce Medical Journal , 23 (Special Issue) , 1-23 . DOI: 10.18678/dtfd.890089
MLA Ullah, S , Al-sehemı, A , Klemeš, J , Saqıb, S , Gondal, S , Saqıb, S , Arshad, A , Saqıb, H , Mukhtar, A , Ibrahım, M , Asıf, S , Bokharı, A . "A Review of the Progress of COVID-19 Vaccine Development" . Duzce Medical Journal 23 (2021 ): 1-23 <https://dergipark.org.tr/en/pub/dtfd/issue/60535/890089>
Chicago Ullah, S , Al-sehemı, A , Klemeš, J , Saqıb, S , Gondal, S , Saqıb, S , Arshad, A , Saqıb, H , Mukhtar, A , Ibrahım, M , Asıf, S , Bokharı, A . "A Review of the Progress of COVID-19 Vaccine Development". Duzce Medical Journal 23 (2021 ): 1-23
RIS TY - JOUR T1 - A Review of the Progress of COVID-19 Vaccine Development AU - Sami Ullah , Abdullah Ghodran Al-sehemı , Jiří Jaromír Klemeš , Sanam Saqıb , Sahibzada Muhammad Azib Gondal , Sidra Saqıb , Akasha Arshad , Hira Saqıb , Ahmad Mukhtar , Muhammad Ibrahım , Saira Asıf , Awais Bokharı Y1 - 2021 PY - 2021 N1 - doi: 10.18678/dtfd.890089 DO - 10.18678/dtfd.890089 T2 - Duzce Medical Journal JF - Journal JO - JOR SP - 1 EP - 23 VL - 23 IS - Special Issue SN - -1307-671X M3 - doi: 10.18678/dtfd.890089 UR - https://doi.org/10.18678/dtfd.890089 Y2 - 2021 ER -
EndNote %0 Düzce Tıp Fakültesi Dergisi A Review of the Progress of COVID-19 Vaccine Development %A Sami Ullah , Abdullah Ghodran Al-sehemı , Jiří Jaromír Klemeš , Sanam Saqıb , Sahibzada Muhammad Azib Gondal , Sidra Saqıb , Akasha Arshad , Hira Saqıb , Ahmad Mukhtar , Muhammad Ibrahım , Saira Asıf , Awais Bokharı %T A Review of the Progress of COVID-19 Vaccine Development %D 2021 %J Duzce Medical Journal %P -1307-671X %V 23 %N Special Issue %R doi: 10.18678/dtfd.890089 %U 10.18678/dtfd.890089
ISNAD Ullah, Sami , Al-sehemı, Abdullah Ghodran , Klemeš, Jiří Jaromír , Saqıb, Sanam , Gondal, Sahibzada Muhammad Azib , Saqıb, Sidra , Arshad, Akasha , Saqıb, Hira , Mukhtar, Ahmad , Ibrahım, Muhammad , Asıf, Saira , Bokharı, Awais . "A Review of the Progress of COVID-19 Vaccine Development". Duzce Medical Journal 23 / Special Issue (March 2021): 1-23 . https://doi.org/10.18678/dtfd.890089
AMA Ullah S , Al-sehemı A , Klemeš J , Saqıb S , Gondal S , Saqıb S , Arshad A , Saqıb H , Mukhtar A , Ibrahım M , Asıf S , Bokharı A . A Review of the Progress of COVID-19 Vaccine Development. Duzce Medical Journal. 2021; 23(Special Issue): 1-23.
Vancouver Ullah S , Al-sehemı A , Klemeš J , Saqıb S , Gondal S , Saqıb S , Arshad A , Saqıb H , Mukhtar A , Ibrahım M , Asıf S , Bokharı A . A Review of the Progress of COVID-19 Vaccine Development. Duzce Medical Journal. 2021; 23(Special Issue): 1-23.
IEEE S. Ullah , A. Al-sehemı , J. Klemeš , S. Saqıb , S. Gondal , S. Saqıb , A. Arshad , H. Saqıb , A. Mukhtar , M. Ibrahım , S. Asıf and A. Bokharı , "A Review of the Progress of COVID-19 Vaccine Development", Duzce Medical Journal, vol. 23, no. Special Issue, pp. 1-23, Mar. 2021, doi:10.18678/dtfd.890089

Authors of the Article
Sami ULLAH [1]
Abdullah Ghodran AL-SEHEMI [2]
Jiří Jaromír KLEMEŠ [3]
Sanam SAQIB [4]
Sahibzada Muhammad Azib GONDAL [5]
Sidra SAQIB [6]
Akasha ARSHAD [7]
Hira SAQIB [8]
Ahmad MUKHTAR [9]
Muhammad IBRAHIM [10]
Awais BOKHARI [12]