Research Article
BibTex RIS Cite

ST-Yükselmeli Miyokard Enfarktüslü Hastalarda Perkütan Koroner Girişim ile Revaskülarizasyon Sonrası Advers Sonucu Öngörmede Çözünür ST2

Year 2021, Volume: 23 Issue: 2, 174 - 180, 30.08.2021
https://doi.org/10.18678/dtfd.889947

Abstract

Amaç: Bu çalışmanın amacı, ST-segment yükselmesi (STEMI) olan miyokard enfarktüslü hastalarda perkütan koroner girişim sonrası tümörijenisitenin çözünür baskılanması 2 (soluble suppression of tumorigenicity 2, sST2) seviyesi ile epikardiyal kan akımının düzelme derecesi arasındaki ilişkinin araştırılmasıdır.
Gereç ve Yöntemler: Çalışmaya ortalama yaşı 59.85±10.01 yıl olan 61 hasta (%83,6 erkek) dahil edildi. sST2 seviyesi enzim immunoassay ile ölçüldü. Hastalar iki gruba ayrıldı. Birinci grup (n=12) miyokard enfarktüsünde tromboliz (thrombolysis in myocardial infarction, TIMI) ≤II akım dereceli hastaları, ikinci grup (n=49) ise TIMI III akım dereceli hastaları içeriyordu.
Bulgular: Epikardiyal kan akımı azalmış (TIMI≤II) olan grupta perkütan koroner girişim sonrası hastalığın ilk saatlerinde sST2 düzeyi anlamlı olarak daha yüksekti (p=0.003). Alıcı işlem karakteristiği eğrisi analizi, başvuru sırasında saptanan 34,2 ng/ml'nin üzerindeki sST2 düzeylerinin, STEMI hastalarında %92,3 duyarlılık ve %62,5 özgüllük ile advers revaskülarizasyonun (TIMI ≤II) bağımsız bir ön gördürücüsü olduğunu göstermiştir; eğri altında kalan alan 0,811 (%95 GA: 0,651 - 0,873; p=0,001) idi. Hem tek değişkenli (OR: 1,020; %95 GA: 1,001-1,041; p=0.028) ve hem de çok değişkenli (OR: 1,030; %95 GA: 1,002-1,057; p=0.033) analizler sST2'nin epikardiyal vasküler revaskülarizasyonun olumsuz sonucunun (TIMI≤ІІ) anlamlı bir ön gördürücüsü olduğunu gösterdi.
Sonuç: sST2, STEMI olan hastalarda perkütan koroner girişim sonrası kan akımındaki iyileşme derecesi ile yüksek oranda ilişkilidir ve prognostik bir belirteç olarak büyük klinik öneme sahiptir.

References

  • Durante A, Camici PG. Novel insights into an "old" phenomenon: the no reflow. Int J Cardiol. 2015;187(1):273-80.
  • Stone GW, Peterson MA, Lansky AJ, Dangas G, Mehran R, Leon MB. Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction. J Am Coll Cardiol. 2002;39(4):591-7.
  • Resnic FS, Wainstein M, Lee MK, Behrendt D, Wainstein RV, Ohno-Machado L, et al. No-reflow is an independent predictor of death and myocardial infarction after percutaneous coronary intervention. Am Heart J. 2003;145(1): 42-6.
  • Kohli P, Bonaca MP, Kakkar R, Kudinova AY, Scirica BM, Sabatine MS, et al. Role of ST2 in non-ST-elevation acute coronary syndrome in the MERLIN-TIMI 36 trial. Clin Chem. 2012;58(1):257-66.
  • Pascual-Figal DA, Januzzi JL. The biology of ST2: the International ST2 Consensus Panel. Am J Cardiol. 2015;115(7 Suppl):3B-7B.
  • Lepojärvi ES, Piira OP, Pääkkö E, Lammentausta E, Risteli J, Miettinen JA, et al. Serum PINP, PIIINP, galectin-3, and ST2 as surrogates of myocardial fibrosis and echocardiographic left venticular diastolic filling properties. Front Physiol. 2015;6:200.
  • Weinberg EO, Shimpo M, De Keulenaer GW, MacGillivray C, Tominaga S, Solomon SD, et al. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation. 2002;106(23):2961-6.
  • Manzano-Fernández S, Mueller T, Pascual-Figal D, Truong QA, Januzzi JL. Usefulness of soluble concentrations of interleukin family member ST2 as predictor of mortality in patients with acutely decompensated heart failure relative to left ventricular ejection fraction. Am J Cardiol. 2011;107(2):259-67.
  • Eggers KM, Armstrong PW, Califf RM, Simoons ML, Venge P, Wallentin L, et al. ST2 and mortality in non-ST-segment elevation acute coronary syndrome. Am Heart J. 2010;159(5):788-94.
  • Jenkins WS, Roger VL, Jaffe AS, Weston SA, AbouEzzeddine OF, Jiang R, et al. Prognostic value of soluble ST2 after myocardial infarction: A community perspective. Am J Med. 2017;130(9):1112.e9-15.
  • Maisel AS, Di Somma S. Do we need another heart failure biomarker: focus on soluble suppression of tumorigenicity 2 (sST2). Eur Heart J. 2017;38(30):2325-33.
  • Plawecki M, Morena M, Kuster N, Chenine L, Leray-Moragues H, Joveret B, et al. sST2 as a new biomarker of chronic kidney disease-induced cardiac remodeling: Impact on risk prediction. Mediators Inflamm. 2018;2018:3952526.
  • Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. ESC Scientific Document Group. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-77.
  • Niccoli G, Burzotta F, Galiuto L, Crea F. Myocardial no-reflow in humans. J Am Coll Cardiol. 2009;54(4):281-92.
  • Villacorta H, Maisel AS. Soluble ST2 testing: A promising biomarker in the management of heart failure. Arq Bras Cardiol. 2016;106(2):145-52.
  • Januzzi JL, Pascual-Figal D, Daniels LB. ST2 testing for chronic heart failure therapy monitoring: The International ST2 Consensus Panel. Am J Cardiol. 2015;115(7 Suppl):70B-5B.
  • AbouEzzeddine OF, McKie PM, Dunlay SM, Stevens SR, Felker GM, Borlaug BA, et al. Suppression of tumorigenicity 2 in heart failure with preserved ejection fraction. J Am Heart Assoc. 2017;6(2):e004382.
  • Rudyk I, Medentseva O. [The role of marker fibrosis ST2 and angiotensinogen gene polymorphism in heart failure progressing in patients with type 2 diabetes mellitus]. Georgian Med News. 2018;2:105-12. Russian.
  • Bayes-Genis A, Zhang Y, Ky B. ST2 and patient prognosis in chronic heart failure. Am J Cardiol. 2015;115(7 Suppl):64B-9B.
  • Díez J. Serum soluble ST2 as a biochemical marker of acute heart failure: future areas of research. J Am Coll Cardiol. 2008;52(18):1466-7.
  • Wu H, Yang S, Wu X, Zhao J, Zhao J, Ning Q, et al. Interleukin-33/ST2 signaling promotes production of interleukin-6 and interleukin-8 in systemic inflammation in cigarette smoke-induced chronic obstructive pulmonary disease mice. Biochem Biophys Res Commun. 2014;450(1):110-6.
  • Tuegel C, Katz R, Alam M, Bhat Z, Bellovich K, de Boer I, et al. GDF-15, galectin 3, soluble ST2, and risk of mortality and cardiovascular events in CKD. Am J Kidney Dis. 2018;72(4):519-28.
  • Avcı A, Somuncu MU, Can M, Akgul F. Could sST2 predict contrast-induced nephropathy in ST-segment elevation myocardial infarction? Int J Gen Med. 2020;13:1297-304.
  • Demissei BG, Valente MA, Cleland JG, O'Connor CM, Metra M, Ponikowski P, et al. Optimizing clinical use of biomarkers in high-risk acute heart failure patients. Eur J Heart Fail. 2016;18(3):269-80.
  • Gupta S, Gupta MM. No reflow phenomenon in percutaneous coronary interventions in ST-segment elevation myocardial infarction. Indian Heart J. 2016;68(4):539-51.
  • Fajar JK, Heriansyah T, Rohman MS. The predictors of no reflow phenomenon after percutaneous coronary intervention in patients with ST elevation myocardial infarction: A meta-analysis. Indian Heart J. 2018;70(Suppl 3):S406-18.
  • Balta S, Celik T, Ozturk C, Kaya MG, Aparci M, Yildirim AO, et al. The relation between monocyte to HDL ratio and no-reflow phenomenon in the patients with acute ST-segment elevation myocardial infarction. Am J Emerg Med. 2016;34(8):1542-7.
  • Zhao Y, Yang J, Ji Y, Wang S, Wang T, Wang F, et al. Usefulness of fibrinogen-to-albumin ratio to predict no-reflow and short-term prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Heart Vessels. 2019;34(10):1600-7.
  • Liu CL, Xue ZQ, Gao SP, Chen C, Chen XH, Pan M, et al. The relationship between interleukin-6 promotor polymorphisms and slow coronary flow phenomenon. Clin Lab. 2016;62(5):947-53.
  • Sabatine MS, Morrow DA, Higgins LJ, MacGillivray C, Guo W, Bode C, et al. Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction. Circulation. 2008;117(15):1936-44.
  • Shimpo M, Morrow DA, Weinberg EO, Sabatine MS, Murphy SA, Antman EM, et al. Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction. Circulation. 2004;109(18):2186-90.

Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction

Year 2021, Volume: 23 Issue: 2, 174 - 180, 30.08.2021
https://doi.org/10.18678/dtfd.889947

Abstract

Aim: The aim of the study was to investigate the relationship between the soluble suppression of tumorigenicity 2 (sST2) level and the degree of epicardial blood flow recovery in patients with myocardial infarction with ST-segment elevation (STEMI) after percutaneous coronary intervention.
Material and Methods: The study involved 61 patients (83.6% males), with a mean age of 59.85±10.01 years. sST2 level was measured by enzyme immunoassay. Patients were divided into two groups. The first group (n=12) included patients with thrombolysis in myocardial infarction (TIMI) ≤II flow grade, the second group (n=49) with TIMI III flow grade.
Results: The sST2 level was significantly higher in the first hours of the disease in the group with decreased epicardial blood flow (TIMI ≤II) after percutaneous coronary intervention (p=0.003). Receiver operating characteristics curve analysis showed that sST2 levels over 34.2 ng/ml, detected on admission, was an independent predictor of adverse revascularization (TIMI ≤II) in patients with STEMI with a sensitivity of 92.3% and a specificity of 62.5%; the area under curve was 0.811 (95% CI: 0.651 - 0.873; p=0.001). Both the univariate (OR: 1.020, 95% CI: 1.001-1.041, p=0.028) and multivariate (OR: 1.030; 95% CI: 1.002-1.057; p=0.033) analyzes showed that sST2 was a significant predictor of the unfavorable outcome of epicardial vascular revascularization (TIMI ≤ІІ).
Conclusion: sST2 is highly associated with the degree of blood flow recovery after percutaneous coronary intervention in patients with STEMI and is of great clinical importance as a prognostic marker.

References

  • Durante A, Camici PG. Novel insights into an "old" phenomenon: the no reflow. Int J Cardiol. 2015;187(1):273-80.
  • Stone GW, Peterson MA, Lansky AJ, Dangas G, Mehran R, Leon MB. Impact of normalized myocardial perfusion after successful angioplasty in acute myocardial infarction. J Am Coll Cardiol. 2002;39(4):591-7.
  • Resnic FS, Wainstein M, Lee MK, Behrendt D, Wainstein RV, Ohno-Machado L, et al. No-reflow is an independent predictor of death and myocardial infarction after percutaneous coronary intervention. Am Heart J. 2003;145(1): 42-6.
  • Kohli P, Bonaca MP, Kakkar R, Kudinova AY, Scirica BM, Sabatine MS, et al. Role of ST2 in non-ST-elevation acute coronary syndrome in the MERLIN-TIMI 36 trial. Clin Chem. 2012;58(1):257-66.
  • Pascual-Figal DA, Januzzi JL. The biology of ST2: the International ST2 Consensus Panel. Am J Cardiol. 2015;115(7 Suppl):3B-7B.
  • Lepojärvi ES, Piira OP, Pääkkö E, Lammentausta E, Risteli J, Miettinen JA, et al. Serum PINP, PIIINP, galectin-3, and ST2 as surrogates of myocardial fibrosis and echocardiographic left venticular diastolic filling properties. Front Physiol. 2015;6:200.
  • Weinberg EO, Shimpo M, De Keulenaer GW, MacGillivray C, Tominaga S, Solomon SD, et al. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation. 2002;106(23):2961-6.
  • Manzano-Fernández S, Mueller T, Pascual-Figal D, Truong QA, Januzzi JL. Usefulness of soluble concentrations of interleukin family member ST2 as predictor of mortality in patients with acutely decompensated heart failure relative to left ventricular ejection fraction. Am J Cardiol. 2011;107(2):259-67.
  • Eggers KM, Armstrong PW, Califf RM, Simoons ML, Venge P, Wallentin L, et al. ST2 and mortality in non-ST-segment elevation acute coronary syndrome. Am Heart J. 2010;159(5):788-94.
  • Jenkins WS, Roger VL, Jaffe AS, Weston SA, AbouEzzeddine OF, Jiang R, et al. Prognostic value of soluble ST2 after myocardial infarction: A community perspective. Am J Med. 2017;130(9):1112.e9-15.
  • Maisel AS, Di Somma S. Do we need another heart failure biomarker: focus on soluble suppression of tumorigenicity 2 (sST2). Eur Heart J. 2017;38(30):2325-33.
  • Plawecki M, Morena M, Kuster N, Chenine L, Leray-Moragues H, Joveret B, et al. sST2 as a new biomarker of chronic kidney disease-induced cardiac remodeling: Impact on risk prediction. Mediators Inflamm. 2018;2018:3952526.
  • Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. ESC Scientific Document Group. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-77.
  • Niccoli G, Burzotta F, Galiuto L, Crea F. Myocardial no-reflow in humans. J Am Coll Cardiol. 2009;54(4):281-92.
  • Villacorta H, Maisel AS. Soluble ST2 testing: A promising biomarker in the management of heart failure. Arq Bras Cardiol. 2016;106(2):145-52.
  • Januzzi JL, Pascual-Figal D, Daniels LB. ST2 testing for chronic heart failure therapy monitoring: The International ST2 Consensus Panel. Am J Cardiol. 2015;115(7 Suppl):70B-5B.
  • AbouEzzeddine OF, McKie PM, Dunlay SM, Stevens SR, Felker GM, Borlaug BA, et al. Suppression of tumorigenicity 2 in heart failure with preserved ejection fraction. J Am Heart Assoc. 2017;6(2):e004382.
  • Rudyk I, Medentseva O. [The role of marker fibrosis ST2 and angiotensinogen gene polymorphism in heart failure progressing in patients with type 2 diabetes mellitus]. Georgian Med News. 2018;2:105-12. Russian.
  • Bayes-Genis A, Zhang Y, Ky B. ST2 and patient prognosis in chronic heart failure. Am J Cardiol. 2015;115(7 Suppl):64B-9B.
  • Díez J. Serum soluble ST2 as a biochemical marker of acute heart failure: future areas of research. J Am Coll Cardiol. 2008;52(18):1466-7.
  • Wu H, Yang S, Wu X, Zhao J, Zhao J, Ning Q, et al. Interleukin-33/ST2 signaling promotes production of interleukin-6 and interleukin-8 in systemic inflammation in cigarette smoke-induced chronic obstructive pulmonary disease mice. Biochem Biophys Res Commun. 2014;450(1):110-6.
  • Tuegel C, Katz R, Alam M, Bhat Z, Bellovich K, de Boer I, et al. GDF-15, galectin 3, soluble ST2, and risk of mortality and cardiovascular events in CKD. Am J Kidney Dis. 2018;72(4):519-28.
  • Avcı A, Somuncu MU, Can M, Akgul F. Could sST2 predict contrast-induced nephropathy in ST-segment elevation myocardial infarction? Int J Gen Med. 2020;13:1297-304.
  • Demissei BG, Valente MA, Cleland JG, O'Connor CM, Metra M, Ponikowski P, et al. Optimizing clinical use of biomarkers in high-risk acute heart failure patients. Eur J Heart Fail. 2016;18(3):269-80.
  • Gupta S, Gupta MM. No reflow phenomenon in percutaneous coronary interventions in ST-segment elevation myocardial infarction. Indian Heart J. 2016;68(4):539-51.
  • Fajar JK, Heriansyah T, Rohman MS. The predictors of no reflow phenomenon after percutaneous coronary intervention in patients with ST elevation myocardial infarction: A meta-analysis. Indian Heart J. 2018;70(Suppl 3):S406-18.
  • Balta S, Celik T, Ozturk C, Kaya MG, Aparci M, Yildirim AO, et al. The relation between monocyte to HDL ratio and no-reflow phenomenon in the patients with acute ST-segment elevation myocardial infarction. Am J Emerg Med. 2016;34(8):1542-7.
  • Zhao Y, Yang J, Ji Y, Wang S, Wang T, Wang F, et al. Usefulness of fibrinogen-to-albumin ratio to predict no-reflow and short-term prognosis in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Heart Vessels. 2019;34(10):1600-7.
  • Liu CL, Xue ZQ, Gao SP, Chen C, Chen XH, Pan M, et al. The relationship between interleukin-6 promotor polymorphisms and slow coronary flow phenomenon. Clin Lab. 2016;62(5):947-53.
  • Sabatine MS, Morrow DA, Higgins LJ, MacGillivray C, Guo W, Bode C, et al. Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction. Circulation. 2008;117(15):1936-44.
  • Shimpo M, Morrow DA, Weinberg EO, Sabatine MS, Murphy SA, Antman EM, et al. Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction. Circulation. 2004;109(18):2186-90.
There are 31 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

Mykola Kopytsya This is me 0000-0003-4779-7347

Yaroslava Hilova This is me 0000-0002-4545-3009

Yuliia Rodionova 0000-0001-8438-9401

Igor Polivenok This is me 0000-0002-0922-1534

Borys Shelest This is me 0000-0001-5528-8302

Publication Date August 30, 2021
Submission Date March 3, 2021
Published in Issue Year 2021 Volume: 23 Issue: 2

Cite

APA Kopytsya, M., Hilova, Y., Rodionova, Y., Polivenok, I., et al. (2021). Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction. Duzce Medical Journal, 23(2), 174-180. https://doi.org/10.18678/dtfd.889947
AMA Kopytsya M, Hilova Y, Rodionova Y, Polivenok I, Shelest B. Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction. Duzce Med J. August 2021;23(2):174-180. doi:10.18678/dtfd.889947
Chicago Kopytsya, Mykola, Yaroslava Hilova, Yuliia Rodionova, Igor Polivenok, and Borys Shelest. “Soluble ST2 in Predicting Adverse Outcome After Revascularization With Percutaneous Coronary Intervention in Patients With ST-Elevation Myocardial Infarction”. Duzce Medical Journal 23, no. 2 (August 2021): 174-80. https://doi.org/10.18678/dtfd.889947.
EndNote Kopytsya M, Hilova Y, Rodionova Y, Polivenok I, Shelest B (August 1, 2021) Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction. Duzce Medical Journal 23 2 174–180.
IEEE M. Kopytsya, Y. Hilova, Y. Rodionova, I. Polivenok, and B. Shelest, “Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction”, Duzce Med J, vol. 23, no. 2, pp. 174–180, 2021, doi: 10.18678/dtfd.889947.
ISNAD Kopytsya, Mykola et al. “Soluble ST2 in Predicting Adverse Outcome After Revascularization With Percutaneous Coronary Intervention in Patients With ST-Elevation Myocardial Infarction”. Duzce Medical Journal 23/2 (August 2021), 174-180. https://doi.org/10.18678/dtfd.889947.
JAMA Kopytsya M, Hilova Y, Rodionova Y, Polivenok I, Shelest B. Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction. Duzce Med J. 2021;23:174–180.
MLA Kopytsya, Mykola et al. “Soluble ST2 in Predicting Adverse Outcome After Revascularization With Percutaneous Coronary Intervention in Patients With ST-Elevation Myocardial Infarction”. Duzce Medical Journal, vol. 23, no. 2, 2021, pp. 174-80, doi:10.18678/dtfd.889947.
Vancouver Kopytsya M, Hilova Y, Rodionova Y, Polivenok I, Shelest B. Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction. Duzce Med J. 2021;23(2):174-80.