Multiple Sklerozlu Hastaların Bellek, Dikkat, Yürütücü İşlevler, İnce Motor Hareket Yönünden Değerlendirilmesi ve Bunların Manyetik Rezonans Görüntüleme Bulguları ile İlişkisi

Year 2024, Volume: 26 Issue: 1, 56 - 63, 30.04.2024

Oruc Sahin , Emine Hande Kılıçaslan Şahin , Ersel Dağ

https://doi.org/10.18678/dtfd.1381925

Abstract

Amaç: Bu çalışmada multipl skleroz (MS) hastalarının bilişsel işlevleri ve ince motor becerilerinin gözden geçirilmesi ve bunların manyetik rezonans görüntüleme (MRG) sonuçları ile ilişkisinin araştırılması amaçlandı.
Gereç ve Yöntemler: Çalışmaya relaps-remisyon tipi MS tanısı alan 22 hasta ve 22 kontrol grubu dahil edildi. Katılımcılara Stroop testi, Rey işitsel sözel öğrenme testi (Rey auditory verbal learning test, RAVLT), çizgi bölme testi (ÇBT), seri seçim reaksiyon testi (SSRT) ve parmak vuru testi (PVT) dahil olmak üzere nöropsikolojik testler uygulandı. Hastalık şiddeti ve MRG ile test performansı arasındaki ilişki de incelendi.
Bulgular: Elde edilen sonuçlara göre ÇBT verilerinde hastaların sağa lateralize olduğu, kontrol grubunun ise sola lateralize olduğu tespit edildi (p=0,024). Bilişsel testlerde, Stroop testi sonuçları arasında anlamlı bir fark bulunmazken (p=0,134), hasta grubunun genel RAVLT ortalaması kontrol grubuna göre anlamlı derecede düşüktü (p<0,001). Hastaların SRTT’deki ortalama reaksiyon süresi anlamlı derecede daha uzundu (p=0,038). Genişletilmiş engellilik durumu ölçeği (expanded disability status scale, EDSS) skoru ile ÇBT sonuçları arasında pozitif bir korelasyon (r=0,326; p=0,031) ve RAVLT sonuçları ile EDSS skoru arasında negatif bir korelasyon belirlendi. İnce motor becerilerde, sağ el PVT sonuçları ile sol hemisferdeki MS plağı sayısı arasında negatif bir korelasyon (r=-0,431; p=0,045) ve SSRT hata sayısı ile jukstakortikal bölgelerdeki plak sayısı arasında pozitif bir korelasyon (p=0.031) tespit edildi.
Sonuç: Bu çalışma, MS hastalığında bilişsel işlevlerdeki bozulmanın hem hastalığın seyri ve şiddetiyle hem de MR bulgularıyla ilişkili olduğunu göstermiştir.

Keywords

Multipl Skleroz, Bilişsel İşlevler, Nöroanatomik Lokalizasyon, İnce Motor Beceri

Evaluation of Patients with Multiple Sclerosis in Terms of Memory, Attention, Executive Functions, Fine Motor Movement and the Association thereof with Magnetic Resonance Imaging Results

Abstract

Aim: This study aimed to review cognitive function and fine motor skills in patients with multiple sclerosis (MS) and investigate the association with magnetic resonance imaging (MRI) results.
Material and Methods: The study included 22 patients diagnosed with relapsing-remitting MS and 22 controls. Participants underwent neuropsychological tests, including the Stroop test, Rey auditory verbal learning test (RAVLT), line bisection test (LBT), serial reaction time test (SRTT), and finger tapping test (FTT). The relationship between severity of disease, MRI, and test performance was investigated.
Results: It was determined that the patients were lateralized to the right in the LBT data, while the control group was lateralized to the left (p=0.024). On cognitive tests, there was no significant difference in Stroop test results (p=0.134), but the mean overall RAVLT of the patient group was significantly lower than that of the control group (p<0.001). Patients had significantly longer reaction times in SRTT (p=0.038). A positive correlation was found between the expanded disability status scale (EDSS) score and LBT results (r=0.326, p=0.031), and a negative correlation between RAVLT results and EDSS score. For fine motor skills, a negative correlation was observed between FTT results and the number of MS plaques in the left hemisphere (r=-0.431, p=0.045), and a positive correlation between the number of SRTT error and the number of plaques in the juxtacortical regions (r=0.461, p=0.031).
Conclusion: This study shows that the impairment of cognitive functions in MS disease is associated with both the course and severity of the disease and MRI findings.

Keywords

Multiple Sclerosis, Cognitive Functions, Neuroanatomical Localization, Fine Motor Skills

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