Geleneksel Tıbbi Uygulamalar Uygulanan ve Uygulanmayan Lomber Disk Hernisi Hastalarında MMP-1 ve TGF-β Düzeylerinin İncelenmesi

Year 2025, Issue: Early Access

Ömer Polat , Sinem Kantarcıoğlu Coşkun , Güven Kılıç

https://doi.org/10.18678/dtfd.1680827

Abstract

Amaç: Lomber disk hastalığı nedeniyle ortaya çıkan kronik ve tekrarlayıcı bel ağrısı, hastaların yaşam kalitelerini ve psikolojik durumlarını önemli ölçüde etkilemektedir. Ağrı nedeniyle hastalar geleneksel tedavilere yönelebilmektedir. Bu çalışmanın amacı, lomber disk hernisi nedeni ile cerrahi uygulanmış hastalarda, geleneksel tıp uygulamaları (GTU) kullanmış ve kullanmamış olmanın etkisini disk ve ligamentum flavum örneklerini inceleyerek araştırmak ve değerlendirmektir.
Gereç ve Yöntemler: Bu çalışmaya, lomber disk hernisi nedeni ile cerrahi tedavi uygulanmış olan 28 (%60,9) erkek ve 18 (%39,1) kadın olmak üzere toplam 46 hasta dahil edildi. Hastaların verilerine hasta kayıt sisteminden geriye dönük olarak ulaşıldı. Cerrahi işlem sırasında çıkarılan disk ve ligamentum flavum örneklerinde immünhistokimyasal boyama yapıldı ve değerlendirildi.
Bulgular: Çalışmaya dahil edilen 46 hastanın 21’i (%45,6) GTU yaptırmış, 25’i (%54,4) ise yaptırmamıştı. GTU uygulanan hastaların MMP-1 ve TGF-β düzeyleri, hem flavum (her iki p<0,001) ve hem de disk (sırasıyla, p=0,014 ve p=0.020) örneklerinde anlamlı düzeyde daha yüksekti. İmmunhistokimyasal boyanma skorları incelendiğinde, GTU uygulanan hastalarda flavum (p<0,001) ve disk (p=0,002) örneklerinde MMP-1 boyanma skorlarının daha yüksek olduğu saptandı.
Sonuç: GTU’nun her hastalık için uygun yöntemler olduğunun düşünülmesi büyük bir yanılgıdır. Bu çalışma, Türk toplumunda giderek kullanım sıklığı artan GTU hakkında halkın doğru bilgilendirilmesinin önemini vurgulamaktadır. Hangi yöntemin hangi hastalık için kullanılabileceğini araştırmak için çok sayıda kontrollü klinik çalışmaya ihtiyaç vardır.

Keywords

Disk hernisi , geleneksel tedavi , MMP-1 , TGF-β

A Study of MMP-1 and TGF-β Levels in Lumbar Disc Herniation Patients With and Without Traditional Medical Practices

Abstract

Aim: Chronic and recurrent low back pain resulting from lumbar disc disease significantly impacts patients' quality of life and psychological well-being. Patients may seek traditional treatments for pain relief. This study aimed to investigate and evaluate the effect of utilizing or not utilizing traditional medical practices (TMPs) in patients who have undergone surgery for lumbar disc herniation, by examining samples of the disc and ligamentum flavum.
Material and Methods: A total of 46 patients, 28 (60.9%) male and 18 (39.1%) female, who underwent surgical treatment for lumbar disc herniation were included in the study. The patients' data were retrieved retrospectively from the patient registry system. Immunohistochemical staining was performed and evaluated on the disk and ligamentum flavum samples removed during the surgical procedure.
Results: Of the 46 patients included in the study, 21 (45.6%) had undergone TMPs, while 25 (54.4%) had not. The levels of MMP-1 and TGF-β of patients who underwent TMPs were significantly higher in both flavum (both p<0.001) and disk (p=0.014 and p=0.020, respectively) samples. When analyzing the immunohistochemical staining scores, it was found that MMP-1 staining scores were higher in the flavum (p<0.001) and disk (p=0.002) samples of patients who underwent TMPs.
Conclusion: The notion that TMPs are suitable methods for all ailments is a significant misconception. This study emphasizes the importance of accurately informing the public about TMPs, given their increasing prevalence in Turkish society. There is a need for further controlled clinical studies to investigate which method can be used for which disease.

Keywords

Disc herniation , traditional therapy , MMP-1 , TGF-β

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