Case Report
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Oral Focal Mucinosis of the Edentulous Area of the Maxilla: A Rare Case Report

Year 2025, Issue: Early Access
https://doi.org/10.18678/dtfd.1685751

Abstract

Oral focal mucinosis (OFM) is a relatively uncommon benign connective tissue lesion of unknown etiology, primarily affecting the gingiva. Clinically, OFM has no specific appearance; it resembles more specific conditions like fibroepithelial hyperplasia and other reactive lesions. Histologically, it is characterized by loose myxoid connective tissue stroma with slightly enlarged fibroblasts. This case report aimed to describe clinical, histological, and immunohistochemical features of an OFM in a 71-year-old edentulous male patient affecting the right maxillary alveolar mucosa. The lesion presented as a painless, dome-shaped, sessile nodule. Histopathological examination revealed a circumscribed area of increased mucin deposition within the lamina propria, devoid of inflammatory cells. This case highlights the importance of considering OFM in the differential diagnosis of soft tissue lesions of the oral cavity, even in edentulous patients, and underscores the diagnostic role of histopathology.

References

  • Gonzaga AK, de Oliveira DH, Lopes ML, Filho TJ, Queiroz LM, da Silveira ÉJ. Clinicopathological study of oral focal mucinosis: a retrospective case series. Med Oral Patol Oral Cir Bucal. 2018;23(4):e401-5.
  • Dill Fuchs L, Borges Kirschnick L, de Farias Gabriel A, Martins Silveira F, Ajudarte Lopes M, Petersen Wagner V, et al. Oral focal mucinosis: A systematic review. Br J Oral Maxillofac Surg. 2024;62(8):669-75.
  • Tomich CE. Oral focal mucinosis. A clinicopathologic and histochemical study of eight cases. Oral Surg Oral Med Oral Pathol. 1974;38(5):714-24.
  • Tonkaboni A, Hafezi Motlagh K, Derakhshan S. Oral focal mucinosis in an adolescent: A rare entity. Clin Case Rep. 2022;10(11):e6594.
  • Ko A, Hyun CL, Lim GC. A submucosal tumor at the base of the tongue. Eur Ann Otorhinolaryngol Head Neck Dis. 2019;136(2):143-5.
  • Bajpai M, Pardhe N. A simplified working classification proposed for myxoid tumors of Oral cavity. Iran J Pathol. 2017;12(4):413‐4.
  • Cameron A, Webster JEN, Wicks CE, Colbert SD. Oral focal mucinosis of the palate: a rare disease entity. BMJ Case Rep. 2020;13(3):e230233.
  • Fusetti M, Silvagni L, Eibenstein A, Chiti-Batelli S, Hueck S, Fusetti M. Myxoid liposarcoma of the oral cavity: case report and review of the literature. Acta Otolaryngol. 2001;121(6):759-62.
  • Bajpai M, Pardhe N, Vijay P. Superficial angiomyxoma of palate. J Coll Physicians Surg Pak. 2017;27(12):794.
  • Chandolia B, Bajpai M, Arora M. Mucoepidermoid carcinoma in a 62-year female. J Coll Physicians Surg Pak. 2017;27(12):793.
  • Xu F, Jin Y, Li Q, Dong F, Lu L, Cui Q, et al. Intradural extramedullary nerve sheath myxoma of the cervical spine: a case report and review of literature. Front Surg. 2022;8:722254.
  • Bajpai M, Pardhe N. Extra-osseous odontogenic myxoma of maxillary gingiva. J Coll Physicians Surg Pak. 2017;27(3):S28-9.

Maksillanın Dişsiz Bölgesinde Oral Fokal Müsinozis: Nadir Bir Olgu Sunumu

Year 2025, Issue: Early Access
https://doi.org/10.18678/dtfd.1685751

Abstract

Oral fokal müsinozis (OFM), etiyolojisi bilinmeyen, nispeten nadir görülen iyi huylu bir bağ dokusu lezyonudur ve öncelikli olarak dişetini etkiler. Klinik olarak OFM'nin spesifik bir görünümü yoktur; fibroepitelyal hiperplazi ve diğer reaktif lezyonlar gibi daha spesifik durumlara benzerlik gösterebilir. Histolojik olarak, hafif büyümüş fibroblastlar içeren gevşek miksoid bağ dokusu stroması ile karakterizedir. Bu olgu sunumunun amacı, 71 yaşında dişsiz bir erkek hastada sağ maksiller alveolar mukozayı etkileyen bir OFM'nin klinik, histolojik ve immünohistokimyasal özelliklerini tanımlamaktır. Lezyon ağrısız, kubbemsi şekilde, sesil bir nodül olarak izlenmiştir. Histopatolojik incelemede, lamina propriada inflamatuvar hücre içermeyen, sınırlı bir alanda artmış müsin birikimi gözlenmiştir. Bu olgu, oral kavite yumuşak doku lezyonlarının ayırıcı tanısında, dişsiz hastalarda dahi, OFM’nin göz önünde bulundurulması gerektiğinin öneminin altını çizmekte ve histopatolojinin tanıdaki rolünü vurgulamaktadır.

References

  • Gonzaga AK, de Oliveira DH, Lopes ML, Filho TJ, Queiroz LM, da Silveira ÉJ. Clinicopathological study of oral focal mucinosis: a retrospective case series. Med Oral Patol Oral Cir Bucal. 2018;23(4):e401-5.
  • Dill Fuchs L, Borges Kirschnick L, de Farias Gabriel A, Martins Silveira F, Ajudarte Lopes M, Petersen Wagner V, et al. Oral focal mucinosis: A systematic review. Br J Oral Maxillofac Surg. 2024;62(8):669-75.
  • Tomich CE. Oral focal mucinosis. A clinicopathologic and histochemical study of eight cases. Oral Surg Oral Med Oral Pathol. 1974;38(5):714-24.
  • Tonkaboni A, Hafezi Motlagh K, Derakhshan S. Oral focal mucinosis in an adolescent: A rare entity. Clin Case Rep. 2022;10(11):e6594.
  • Ko A, Hyun CL, Lim GC. A submucosal tumor at the base of the tongue. Eur Ann Otorhinolaryngol Head Neck Dis. 2019;136(2):143-5.
  • Bajpai M, Pardhe N. A simplified working classification proposed for myxoid tumors of Oral cavity. Iran J Pathol. 2017;12(4):413‐4.
  • Cameron A, Webster JEN, Wicks CE, Colbert SD. Oral focal mucinosis of the palate: a rare disease entity. BMJ Case Rep. 2020;13(3):e230233.
  • Fusetti M, Silvagni L, Eibenstein A, Chiti-Batelli S, Hueck S, Fusetti M. Myxoid liposarcoma of the oral cavity: case report and review of the literature. Acta Otolaryngol. 2001;121(6):759-62.
  • Bajpai M, Pardhe N, Vijay P. Superficial angiomyxoma of palate. J Coll Physicians Surg Pak. 2017;27(12):794.
  • Chandolia B, Bajpai M, Arora M. Mucoepidermoid carcinoma in a 62-year female. J Coll Physicians Surg Pak. 2017;27(12):793.
  • Xu F, Jin Y, Li Q, Dong F, Lu L, Cui Q, et al. Intradural extramedullary nerve sheath myxoma of the cervical spine: a case report and review of literature. Front Surg. 2022;8:722254.
  • Bajpai M, Pardhe N. Extra-osseous odontogenic myxoma of maxillary gingiva. J Coll Physicians Surg Pak. 2017;27(3):S28-9.
There are 12 citations in total.

Details

Primary Language English
Subjects Otorhinolaryngology, Pathology
Journal Section Case Report
Authors

Shubhangi Mani 0009-0008-4160-6857

Deepak Singh 0000-0002-5841-1764

Manas Bajpai 0000-0001-6168-3069

Early Pub Date October 1, 2025
Publication Date October 6, 2025
Submission Date April 29, 2025
Acceptance Date September 3, 2025
Published in Issue Year 2025 Issue: Early Access

Cite

APA Mani, S., Singh, D., & Bajpai, M. (2025). Oral Focal Mucinosis of the Edentulous Area of the Maxilla: A Rare Case Report. Duzce Medical Journal(Early Access). https://doi.org/10.18678/dtfd.1685751
AMA Mani S, Singh D, Bajpai M. Oral Focal Mucinosis of the Edentulous Area of the Maxilla: A Rare Case Report. Duzce Med J. October 2025;(Early Access). doi:10.18678/dtfd.1685751
Chicago Mani, Shubhangi, Deepak Singh, and Manas Bajpai. “Oral Focal Mucinosis of the Edentulous Area of the Maxilla: A Rare Case Report”. Duzce Medical Journal, no. Early Access (October 2025). https://doi.org/10.18678/dtfd.1685751.
EndNote Mani S, Singh D, Bajpai M (October 1, 2025) Oral Focal Mucinosis of the Edentulous Area of the Maxilla: A Rare Case Report. Duzce Medical Journal Early Access
IEEE S. Mani, D. Singh, and M. Bajpai, “Oral Focal Mucinosis of the Edentulous Area of the Maxilla: A Rare Case Report”, Duzce Med J, no. Early Access, October2025, doi: 10.18678/dtfd.1685751.
ISNAD Mani, Shubhangi et al. “Oral Focal Mucinosis of the Edentulous Area of the Maxilla: A Rare Case Report”. Duzce Medical Journal Early Access (October2025). https://doi.org/10.18678/dtfd.1685751.
JAMA Mani S, Singh D, Bajpai M. Oral Focal Mucinosis of the Edentulous Area of the Maxilla: A Rare Case Report. Duzce Med J. 2025. doi:10.18678/dtfd.1685751.
MLA Mani, Shubhangi et al. “Oral Focal Mucinosis of the Edentulous Area of the Maxilla: A Rare Case Report”. Duzce Medical Journal, no. Early Access, 2025, doi:10.18678/dtfd.1685751.
Vancouver Mani S, Singh D, Bajpai M. Oral Focal Mucinosis of the Edentulous Area of the Maxilla: A Rare Case Report. Duzce Med J. 2025(Early Access).