Adenomatoid Hyperplasia of The Oral Cavity: A Diagnostic Dilemma

Abstract

Purpose: This review study presents literature review and discusses the clinical significance of Adenomatoid Hyperplasia; a commonly misdiagnosed lesion. This rare entity has been seldom presented and is not well enough described in the literature. Methods: Only 15 reports with 95 cases could be attained during the online literature search using the keywords: Adenomatoid, Tumor, Hyperplasia, Minor salivary Glands. Results: Data revealed a tendency towards the male gender. Age distribution of patients did not reveal a tendency towards a specific age group but presented a peak incidence in the 4th and 5th decades. Location data revealed a tendency towards the palate, especially the hard palate. Most of the presented cases were asymptomatic and the most common initial diagnosis made was salivary gland tumor. Conclusion: Adenomatoid hyperplasia of the oral cavity may resemble a wide range of pathologies. In order to differentiate and to achieve a correct diagnosis, histological evaluation is fundamental.

Keywords

• Adenomatoid Tumor
• Adenomatoid Hyperplasia
• Minor salivary Glands
• Hyperplasia

References

1. 1. Grays Anatomy 41st edition, Editor: Susan Standring, Elsevier; 2016.
2. 2. Moore Clinically Oriented Anatomy 7th edition, Wolters Kluwer, Lippincott Williams & Wilkins; 2014.
3. 3. Giansanti JS, Baker GO, Waldron CA. [Intraoral, mucinous, minor salivary gland lesions presenting clinically as tumors]. Oral Surg Oral Med Oral Pathol 1971;32(6):918-922.
4. 4. Manor E, Sinelnikov I, Brennan PA, Bodner L. [Chromosomal aberrations in adenomatoid hyperplasia of palatal minor salivary gland]. Br J Oral Maxillofac Surg 2013;51(2):170-172.
5. 5. Barrett AW, Speight PM. [Adenomatoid hyperplasia of oral minor salivary glands]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;79(4):482-487.
6. 6. Arafat A, Brannon RB, Ellis GL. Adenomatoid hyperplasia of mucous salivary glands. Oral Surg Oral Med Oral Pathol 1981;52(1):51-55.
7. 7. Brown FH, Houston GD, Lubow RM, Sagan MA. [Adenomatoid Hyperplasia of Mucous Salivary Glands* Report of Two Cases]. J Periodontol 1987;58(2):125-127.
8. 8. Brannon RB, Houston GD, Meader CL. [Adenomatoid hyperplasia of mucous salivary glands: a case involving the retromolar area]. Oral Surg Oral Med Oral Pathol 1985;60(2):188-190.

9. 9. Buchner A, Merrell PW, Carpenter WM, Leider AS. [Adenomatoid hyperplasia of minor salivary glands]. Oral surgery, oral medicine, oral pathology 1991;71(5):583-587.
10. 10. Bryant C, Manisali M, Barrett AW. [Adenomatoid hyperplasia of palatal minor salivary glands]. The Journal of Laryngology & Otology 1996;110(2):167-169.
11. 11. Tagawa S, Inui M, Mori A, Seki Y, Murata T, Tagawa T. Adenomatoid serous hyperplasia of sublingual gland: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol, and Endod 1996;82(4):437-440.
12. 12. Nozaki S, Araki A, Nakagawa K, Yamamoto E. Adenomatoid hyperplasia of the palate in an Asian child. J Oral Maxillofac Surg 1996;54(5);627-628.
13. 13. Campos LA. Hyperplasia of the sublingual glands in adult patients. Oral Surg Oral Med Oral Pathol Oral Radiol and Endod 1996;81(5):584-585.
14. 14. Chen YK, Lin CC, Lin LM, Yan YH. Adenomatoid hyperplasia in the mandibular retromolar area. Case report. Aust Dent J 1999;44(2):135-136.
15. 15. Shimoyama T, Wakabayashi M, Kato T, Kaneko T, Horie N, Ide F. Adenomatoid hyperplasia of the palate mimicking clinically as a salivary gland tumor. J Oral Sci 2001;43(2):135-138.
16. 16. Sharma GK, Sharma M, Vanaki SS. Adenomatoid hyperplasia of lower lip. Dental research journal 2011;8(4):226.
17. 17. Dereci Ö, Çimen E. Adenomatoid hyperplasia of the minor salivary glands on the buccal mucosa: A rare case report. Int J Surg Case Rep 2014;5(5):274-276.
18. 18. Petri III WH, Carr RF, Kahn CS. Adenomatoid hyperplasia of the palate. J Oral Maxillofac Surg 1993;51(3):310-311.
19. 19. Devildos LR, Langlois CC. Minor salivary gland lesion presenting clinically as tumor. Oral Surg Oral Med Oral Pathol 1976;41(5):657-659.
20. 20. Carlos R, Aguirre JM, Pineda V. Asymptomatic posterolateral lingual mass. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:654-656.
21. 21. Aufdemorte TB, Ramzy I, Holt GR, Thomas JR, Duncan DL. Focal adenomatoid hyperplasia of salivary glands. A differential diagnostic problem in fine needle aspiration biopsy. Acta cytological 1984;29(1);23-28.
22. 22. Scully C, Eveson JW, Richards A. Adenomatoid hyperplasia in the palate: another sheep in wolf's clothing. Br Dent J 1992;173(4):141-142.
23. 23. Guallart DF, Molina MA, González MM, Pons RF, Mompó RL, Serrano BE. Adenomatoid hyperplasia of minor salivary glands. An Otorrinolaringol Ibero Am 1994;275-280.
24. 24. Tucci E, Pompa G, Massà R, Guerra F, Santilli D. Adenomatoid hyperplasia of the minor salivary glands. Report of a clinical case. Minerva Stomatol 1995;45(1-2):49-52.
25. 25. Luna MA. Salivary Gland Hyperplasia: On: Adenomatous ductal proliferation of the salivary gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:215–221. Advances in anatomic pathology 2001.2002;9(4):251-255.
26. 26. Radi ZA, Morton DG. Lip Salivary-Gland Hamartoma in a Cynomolgus Macaque (Macaca fascicularis). Comparative medicine 2014;64(1):68-70.
27. 27. Hupp JR, Ellis III E, Tucker MR. Contemporary Oral and Maxillofacial Surgery. India: Mosby; 2013.