Toxic Effect of Pesticides on Aldose Reductase Enzyme.

Veysel Çomaklı; Şevki Adem; Çağlar Güler

EN

Toxic Effect of Pesticides on Aldose Reductase Enzyme.

Abstract

In this study, the effect of pesticides on the enzyme activity of Aldose reductase (AR) (EC 1.1.1.21), which is involved in polyol pathway and detoxification reactions, has been investigated.For this purpose, AR enzyme was purified from chicken liver and the IC₅₀ values were plotted as % Activity-[I] for pesticides with inhibition effect and The maximum inhibitory effect was determined at 2,4,5-T with 162μM.

Keywords

enzyme,aldose reductase,inhibition

References

1. Straathof, A. J.; Panke, S.; Schmid, A., The production of fine chemicals by biotransformations. Current opinion in biotechnology 2002, 13, (6), 548-556.2. Pollard, D. J.; Woodley, J. M., Biocatalysis for pharmaceutical intermediates: the future is now. TRENDS in Biotechnology 2007, 25, (2), 66-73.3. Şengül, B.; Beydemir, Ş., The interactions of cephalosporins on polyol pathway enzymes from sheep kidney. Archives of physiology and biochemistry 2018, 124, (1), 35-44.

Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Veysel Çomaklı ^*
Türkiye

Şevki Adem This is me

Çağlar Güler This is me

Publication Date

November 1, 2018

Submission Date

August 29, 2018

Acceptance Date

October 24, 2018

Published in Issue

Year 2018 Volume: 4 Number: 2

IZ

https://izlik.org/JA22KH27EM

Cite

RIS / Bibtex

APA

Çomaklı, V., Adem, Ş., & Güler, Ç. (2018). Toxic Effect of Pesticides on Aldose Reductase Enzyme. Eastern Anatolian Journal of Science, 4(2), 1-5. https://izlik.org/JA22KH27EM

AMA

1.Çomaklı V, Adem Ş, Güler Ç. Toxic Effect of Pesticides on Aldose Reductase Enzyme. Eastern Anatolian Journal of Science. 2018;4(2):1-5. https://izlik.org/JA22KH27EM

Chicago

Çomaklı, Veysel, Şevki Adem, and Çağlar Güler. 2018. “Toxic Effect of Pesticides on Aldose Reductase Enzyme”. Eastern Anatolian Journal of Science 4 (2): 1-5. https://izlik.org/JA22KH27EM.

EndNote

Çomaklı V, Adem Ş, Güler Ç (November 1, 2018) Toxic Effect of Pesticides on Aldose Reductase Enzyme. Eastern Anatolian Journal of Science 4 2 1–5.

IEEE

[1]V. Çomaklı, Ş. Adem, and Ç. Güler, “Toxic Effect of Pesticides on Aldose Reductase Enzyme”., Eastern Anatolian Journal of Science, vol. 4, no. 2, pp. 1–5, Nov. 2018, [Online]. Available: https://izlik.org/JA22KH27EM

ISNAD

Çomaklı, Veysel - Adem, Şevki - Güler, Çağlar. “Toxic Effect of Pesticides on Aldose Reductase Enzyme”. Eastern Anatolian Journal of Science 4/2 (November 1, 2018): 1-5. https://izlik.org/JA22KH27EM.

JAMA

1.Çomaklı V, Adem Ş, Güler Ç. Toxic Effect of Pesticides on Aldose Reductase Enzyme. Eastern Anatolian Journal of Science. 2018;4:1–5.

MLA

Çomaklı, Veysel, et al. “Toxic Effect of Pesticides on Aldose Reductase Enzyme”. Eastern Anatolian Journal of Science, vol. 4, no. 2, Nov. 2018, pp. 1-5, https://izlik.org/JA22KH27EM.

Vancouver

1.Veysel Çomaklı, Şevki Adem, Çağlar Güler. Toxic Effect of Pesticides on Aldose Reductase Enzyme. Eastern Anatolian Journal of Science [Internet]. 2018 Nov. 1;4(2):1-5. Available from: https://izlik.org/JA22KH27EM