Enzyme Inhibition Studies of Antipyrine and Aminopyrine

Abstract

The study investigated the enzyme inhibition effects of antipyrine and aminopyrine against two human carbonic anhydrase isoforms (hCA I and hCA II), acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The effectiveness of these compounds as possible carbonic anhydrase (CA) and cholinesterase (ChE) inhibitors is evident from the nanomolar range IC₅₀ and K_i values obtained. The results demonstrated that aminopyrine was a more effective inhibitor compared with antipyrine. Moreover, molecular docking results obtained from the online docking server SwissDock supported the inhibition activity results.

Keywords

• Aminopyrine,Antipyrine,Acetylcholinesterase,Butyrylcholinesterase,Carbonic Anhydrase

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