Sectionary Analysis Of Thyroid Function Tests, Vitamin B12 And Folic Acid Levels In Patients With Type 2 Diabetes Mellitus, Hypertension, Chronic Renal Disease And Gastroesophageal Reflux Disease

Abstract

The most common diseases presenting to the internal medicine outpatient clinic are type 2 diabetes mellitus, hypertension, chronic kidney disease and gastroesophageal reflux disease. Thyroid function tests, vitamin B12 and folic acid levels were compared in these diseases. Within the scope of the study, 91 patients were included in the study. Cases with type 2 diabetes mellitus, hypertension, chronic kidney disease and gastroesophageal reflux disease as chronic diseases were examined in the study. In this context, besides demographic data and routine biochemical data, TSH, fT4, fT4, vitamin B12 and folic acid levels were also scanned retrospectively from patient files. The mean age of the 91 patients included in the study was 61.29 ± 14.23 and was not statistically different between the groups. The FT3 level was found to be the highest in the first group compared to the other groups, but it was not statistically significant (p=0.863). The highest FT4 level was detected in group 4, but it was not statistically significant (p=0.839). TSH value was found to be the highest in the gastroesophageal reflux disease group and was not statistically significant when compared to other groups (p=0.898). The comparison of folic acid and vitamin B12 levels between the groups was not statistically significant (p=0.605). Spearmens’s correlation analysis revealed folic acid was significantly positive correlated with folic acid (rho=0.797, p=0.001). TSH levels were not significantly corelated with fT3, fT4, folic acid and vitamin B12 (rho=0.015, p=0.891; rho= -0.177, p=0.093; rho=0.011, p=0.916; rho=0.153, p=0.147). This study demonstrated that serum TSH, ft3, ft4, vitamin b12 and folic acid levels were found similar in all groups. On the other hand, significant difference ws not found between groups in term of TSH,fT3, fT4, vitamin B12 and folic acid.

Keywords

• Type 2 diabetes mellitus
• hypertension
• chronic renal diseas
• gastroesophageal reflux disease

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