68Ga-DOTATATE PET/CT on the Follow-up of Patients with Medullary Thyroid Carcinoma

Ebuzer Kalender; Vuslat Çimen; Umut Elboga; Ufuk Çimen; Zeki Çelen

doi:10.46871/eams.1364159

EN

68Ga-DOTATATE PET/CT on the Follow-up of Patients with Medullary Thyroid Carcinoma

Abstract

The purpose of this study is to evaluate the impact of 68Ga-DOTATE PET/CT on the management of medullary thyroid carcinoma (MTC). Eighteen patients (9 males and 9 females) with MTC who underwent 68Ga-DOTATE PET/CT for elevated calcitonin(Ct) levels were included in this study. Histopathological data, laboratory findings, 68Ga-DOTATE PET/CT findings were evaluated for each patient. 68Ga-DOTATATE PET/CT imaging findings were negative in 5 of 18 patients (27.8%) and positive in 13 of 18 patients (72.2%). The mean Ct level of patients with positive findings was higher than others. 68Ga-DOTATATE PET/CT was insufficient for detecting liver metastases in two patients who exhibited hypermetabolic uptakes consistent with solitary metastases in the liver on 18FDG-PET/CT. We believe that 68Ga-DOTATATE PET/CT plays an important role in the management of MTC patients with recurrent or metastatic disease. Its sensitivity is directly proportional to the levels of serum Ct. However, it may have limitations in detecting liver metastases.

Keywords

Ethical Statement

Ethics approval and consent to participate: The study was performed according to the principles of the Declaration of Helsinki, and approval was granted by the Local Ethics Committee (date: 24.05.2023, no: 172).

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Details

Primary Language

English

Subjects

Clinical Oncology, Nuclear Medicine

Journal Section

Research Article

Authors

Ebuzer Kalender ^*
Türkiye

Vuslat Çimen
Türkiye

Umut Elboga
Türkiye

Ufuk Çimen
Türkiye

Zeki Çelen
Türkiye

Early Pub Date

October 25, 2023

Publication Date

November 30, 2023

Submission Date

September 21, 2023

Acceptance Date

October 18, 2023

Published in Issue

Year 2023 Volume: 4 Number: 2

DOI

https://doi.org/10.46871/eams.1364159

IZ

https://izlik.org/JA87RE95TU

Cite

RIS / Bibtex

APA

Kalender, E., Çimen, V., Elboga, U., Çimen, U., & Çelen, Z. (2023). 68Ga-DOTATATE PET/CT on the Follow-up of Patients with Medullary Thyroid Carcinoma. Experimental and Applied Medical Science, 4(2), 526-531. https://doi.org/10.46871/eams.1364159

AMA

1.Kalender E, Çimen V, Elboga U, Çimen U, Çelen Z. 68Ga-DOTATATE PET/CT on the Follow-up of Patients with Medullary Thyroid Carcinoma. Exp Appl Med Sci. 2023;4(2):526-531. doi:10.46871/eams.1364159

Chicago

Kalender, Ebuzer, Vuslat Çimen, Umut Elboga, Ufuk Çimen, and Zeki Çelen. 2023. “68Ga-DOTATATE PET CT on the Follow-up of Patients With Medullary Thyroid Carcinoma”. Experimental and Applied Medical Science 4 (2): 526-31. https://doi.org/10.46871/eams.1364159.

EndNote

Kalender E, Çimen V, Elboga U, Çimen U, Çelen Z (November 1, 2023) 68Ga-DOTATATE PET/CT on the Follow-up of Patients with Medullary Thyroid Carcinoma. Experimental and Applied Medical Science 4 2 526–531.

IEEE

[1]E. Kalender, V. Çimen, U. Elboga, U. Çimen, and Z. Çelen, “68Ga-DOTATATE PET/CT on the Follow-up of Patients with Medullary Thyroid Carcinoma”, Exp Appl Med Sci, vol. 4, no. 2, pp. 526–531, Nov. 2023, doi: 10.46871/eams.1364159.

ISNAD

Kalender, Ebuzer - Çimen, Vuslat - Elboga, Umut - Çimen, Ufuk - Çelen, Zeki. “68Ga-DOTATATE PET CT on the Follow-up of Patients With Medullary Thyroid Carcinoma”. Experimental and Applied Medical Science 4/2 (November 1, 2023): 526-531. https://doi.org/10.46871/eams.1364159.

JAMA

1.Kalender E, Çimen V, Elboga U, Çimen U, Çelen Z. 68Ga-DOTATATE PET/CT on the Follow-up of Patients with Medullary Thyroid Carcinoma. Exp Appl Med Sci. 2023;4:526–531.

MLA

Kalender, Ebuzer, et al. “68Ga-DOTATATE PET CT on the Follow-up of Patients With Medullary Thyroid Carcinoma”. Experimental and Applied Medical Science, vol. 4, no. 2, Nov. 2023, pp. 526-31, doi:10.46871/eams.1364159.

Vancouver

1.Ebuzer Kalender, Vuslat Çimen, Umut Elboga, Ufuk Çimen, Zeki Çelen. 68Ga-DOTATATE PET/CT on the Follow-up of Patients with Medullary Thyroid Carcinoma. Exp Appl Med Sci. 2023 Nov. 1;4(2):526-31. doi:10.46871/eams.1364159

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Cancers

https://doi.org/10.3390/cancers16244236