INVESTIGATION OF INFLAMMATORY MARKER LEVELS IN OVERACTIVE BLADDER PATIENTS

Abstract

Aim: To investigate whether inflammation plays a role in the pathogenesis of patients diagnosed with overactive bladder (OAB). Material-Method: Patients who applied to the urology outpatient clinic with a preliminary diagnosis of OAB between March 2022 and September 2023 and were diagnosed were prospectively included in the study. Demographic data of the patients, such as age, gender and body mass index (BMI), were recorded. The number of urgency attacks, pollakiuria and nocturia, OAB-V8 scores (0-40) and the anticholinergics used were recorded. Blood group, whole blood and biochemical values measured from peripheral blood at outpatient clinic admissions, among the inflammation markers neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), C reactive protein/albumin (CRP/Albumin) ratio and Deritis (AST/ALT) ratios were recorded. Patients with urinary tract infection, renal function test abnormalities, and patients with a history of previous urological surgery were excluded from the study. Patients who presented to the outpatient clinic with non-OAB were included as the control group. Hemogram and biochemical values of these patients were also recorded. Data recorded at baseline were compared between groups. Results: A total of 198 patients were included in the study (OAB group n: 99, control group n: 99). The mean age of all patients was 52.3±15 years, and the mean OAB-V8 score was 11.9±9.9. No statistically significant difference was observed between the groups in terms of gender and blood group. No statistically significant difference was observed between the groups in terms of hemoglobin, hematocrit, lymphocyte, platelet, AST, ALT, albumin, NLR, LMR, PLR, Deritis, MLR and CRP/albumin ratio. The mean age of the OAB group was found to be significantly higher than the control group (p<0.001). The mean WBC, neutrophil, monocyte and CRP values of the control group were found to be statistically significantly higher than the OAB group. As a result of the multivariate analysis, only age was found to be a predictor for OAB. Conclusion: Although inflammation is thought to play a role in the pathogenesis of OAB, according to the results of our study, inflammation markers were found to be low in OAB patients.

Keywords

• Overactive bladder
• inflammation
• neutrophils

References

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