Systemic Inflammatory Index and Platelet-to-Lymphocyte Ratio Predicted Mortality in patients with Acute Myocardial Infarction

Abstract

In this study, we aimed to evaluate the relationship between the laboratory parameters of platelet volume / lymphocyte ratio (PLR) and systemic inflammatory index (SII) with prognosis and mortality in patients with hospitalized GFR (Glomerular filtration rate) <60 and a diagnosis of acute myocardial infarction (AMI). This study was designed as a retrospective cohort study. 235 myocardial infarction (MI) patients over the age of 18 and with GFR <60, hospitalized in our hospital between January 01, 2016 and January 01, 2019, were included in the study. The patients were divided into 2 groups as survive and mortality. The two groups were compared in terms of demographic characteristics, clinical data (symptoms, comorbidities, laboratory findings, GFR, coronary angiography, drugs used and complications in patients. Platelet - lymphocyte ratio (PLR) was found by dividing platelet count by lymphocyte count. Systemic inflammatory index (SII) was found by multiplying neutrophil count and PLR value. The average age of the survive was 67.1±12,8 (32-101). In the mortality group, the mean age was 69.55±11,1 (46-100). PLR and SII levels were statistically significantly higher in the mortality group compared to the survive group (p=0.002, p=0.029, respectively). According to the results of ROC analysis in patients with mortality, sensitivity 59.1% and specificity 70.4% for PLR (p=0.002); sensitivity 54.5% and specificity 60.9% for SII (p=0.029). The risk factors found to be significantly associated with mortality in the regression analysis included PLR (β: 0.007, OR (95% CI): 1.007 (1.001-1.012), p=0.001) and SII (β: 0.001, OR (95% CI): 1.000 (0.999-1.001), p=0.041). As inexpensive and easily available new inflammatory markers, PLR and SII were significantly higher in patients with GFR <60 and died from acute myocardial infarction (AMI). In addition, PLR and SII were able to predict the mortality from myocardial infarction.

Keywords

• Acute myocardial infarction
• Mortality
• Platelet - lymphocyte ratio
• Systemic inflammatory index

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