Clinical Presentation and Frequency of Klatskin Tumor; A Single-Center Retrospective Study

Abstract

Clinical Presentation and Frequency of Klatskin Tumor; A Single-Center Retrospective Study Abstract Objective: Klatskin tumor is an epithelial bile duct tumor that originates from the main hepatic duct or the right-left intrahepatic duct and appears proximal to the opening of the cystic duct. In this study, we examined the demographic characteristics, clinical, laboratory and radiological results at the time of first presentation of patients who were diagnosed with klatskin tumor in our clinic for a period of three years. Materials and Methods: For the study; 16 patients who were hospitalized at Internal Medicine Clinic between June 1, 2015-May 1, 2018 were diagnosed with Klatskin tumor were included retrospectively. Clinical, laboratory and radiological data of patients were analyzed. Results: 16 patients in the study, 10 were male, 6 were female. Average age was 62.30 for males, 65.33 for females. The most common symptoms respectively jaundice, itching, abdominal pain, anorexia and weakness. Among the laboratory tests, the average of some values; AST:141.31 IU/L, ALT:156.18 IU /L, ALP:692.07 IU/L, GGT:622.14 IU/L, T. Bilirubin:10.42 mg/dl, D. Bilirubin: 6.0 mg/dl, WBC:10.509 x103µ/L. Diagnostic ERCPs of the patients were examined; Klatskin tumor was considered in 14 patients due to stenosis in the proximal part of the common bile duct. Conclusion: Clinical and laboratory findings in Klatskin tumors are not specific and the diagnosis is usually made in the late period because the clinical presentation of the disease is confused with many other diseases.

Keywords

• Klatskin Tumor
• Cholangiocharcinoma
• ERCP
• Clinichal Presentation

Abstract

Klatskin Tümörünün Klinik Sunumu ve Sıklığı; Tek Merkezli Retrospektif Bir Çalışma Özet Amaç: Klatskin tümörü ana hepatik kanaldan veya sağ-sol intrahepatik kanaldan köken alan ve kistik kanalın açıklığının proksimalinde görünen bir epitelyal safra kanalı tümörüdür. Bu çalışmada, kliniğimizde üç yıllık bir süre boyunca klatskin tümörü tanısı alan hastaların ilk başvuru anındaki demografik özellikleri, klinik, laboratuvar ve radyolojik sonuçları incelenmiştir. Gereç ve Yöntem: Çalışma için; 1 Haziran 2015-1 Mayıs 2018 tarihleri arasında Dahiliye Kliniğine yatırılan Klatskin tümörü tanısı konulan 16 hasta retrospektif olarak çalışmaya dahil edildi. Hastaların klinik, laboratuvar ve radyolojik verileri analiz edildi. Bulgular: Çalışmaya alınan 16 hasta, 10'u erkek, 6'sı kadındı. Ortalama yaş erkeklerde 62.30, kadınlarda 65.33 idi. En sık görülen semptomlar sırasıyla sarılık, kaşıntı, karın ağrısı, iştahsızlık ve halsizliktir. Laboratuvar testleri arasında bazı değerlerin ortalaması; AST:141.31 IU/L, ALT:156.18 IU/L, ALP:692.07 IU/L, GGT:622.14 IU/L, T. Bilirubin:10.42 mg/dl, D. Bilirubin: 6,0 mg/dl, WBC:10.509 x 103 µ/L. Hastaların tanısal ERCP'leri incelendi; Koledok proksimalinde darlık nedeniyle 14 hastada Klatskin tümörü düşünüldü. Sonuç: Klatskin tümörlerinde klinik ve laboratuvar bulgular spesifik olmayıp, hastalığın klinik prezentasyonu diğer birçok hastalıkla karıştırıldığı için tanı genellikle geç dönemde konulmaktadır.

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