Chemotherapy-Associated Osteonecrosis of the Jaw in Acute Lymphoblastic Leukemia: Report of a Rare Clinical Case

Gülsün Aydoğmuş; Fatma Büşra Akgül; Elaheh Nasiri

doi:10.62243/edr.1918505

Chemotherapy-Associated Osteonecrosis of the Jaw in Acute Lymphoblastic Leukemia: Report of a Rare Clinical Case

Abstract

Aim To present a rare case of medication-related osteonecrosis of the jaw (MRONJ) in a patient with acute lymphoblastic leukemia (ALL) who developed the condition during chemotherapy, in the absence of antiresorptive or antiangiogenic therapy, and to describe its successful surgical management. Case Report A 56-year-old male undergoing chemotherapy for T-cell ALL developed Stage 2 MRONJ during the maintenance phase, despite having no history of antiresorptive or antiangiogenic drug use. Surgical debridement combined with platelet rich fibrin (PRF) application led to complete clinical healing within four months. Discussion This case emphasizes that MRONJ can occur in hematologic malignancy patients receiving chemotherapy alone. The outcome highlights the importance of considering chemotherapy as a potential risk factor and supports the Conclusion MRONJ should be recognized as a possible complication in patients with ALL undergoing chemotherapy, even without exposure to antiresorptive agents. Surgical management with adjunctive PRF may enhance healing outcomes in such cases.

Keywords

References

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Details

Primary Language

English

Subjects

Oral and Maxillofacial Surgery

Journal Section

Case Report

Authors

Gülsün Aydoğmuş
0000-0002-9931-0628
Türkiye

Fatma Büşra Akgül
0000-0002-9229-1559
Türkiye

Elaheh Nasiri ^*
0009-0006-7782-4181
Türkiye

Publication Date

August 3, 2026

Submission Date

April 13, 2026

Acceptance Date

May 18, 2026

Published in Issue

Year 2026 Volume: 4 Number: 2

DOI

https://doi.org/10.62243/edr.1918505

IZ

https://izlik.org/JA56ZT87PZ

Cite

RIS / Bibtex

APA

Aydoğmuş, G., Akgül, F. B., & Nasiri, E. (2026). Chemotherapy-Associated Osteonecrosis of the Jaw in Acute Lymphoblastic Leukemia: Report of a Rare Clinical Case. Eurasian Dental Research, 4(2), 45-49. https://doi.org/10.62243/edr.1918505

AMA

1.Aydoğmuş G, Akgül FB, Nasiri E. Chemotherapy-Associated Osteonecrosis of the Jaw in Acute Lymphoblastic Leukemia: Report of a Rare Clinical Case. EDR. 2026;4(2):45-49. doi:10.62243/edr.1918505

Chicago

Aydoğmuş, Gülsün, Fatma Büşra Akgül, and Elaheh Nasiri. 2026. “Chemotherapy-Associated Osteonecrosis of the Jaw in Acute Lymphoblastic Leukemia: Report of a Rare Clinical Case”. Eurasian Dental Research 4 (2): 45-49. https://doi.org/10.62243/edr.1918505.

EndNote

Aydoğmuş G, Akgül FB, Nasiri E (August 1, 2026) Chemotherapy-Associated Osteonecrosis of the Jaw in Acute Lymphoblastic Leukemia: Report of a Rare Clinical Case. Eurasian Dental Research 4 2 45–49.

IEEE

[1]G. Aydoğmuş, F. B. Akgül, and E. Nasiri, “Chemotherapy-Associated Osteonecrosis of the Jaw in Acute Lymphoblastic Leukemia: Report of a Rare Clinical Case”, EDR, vol. 4, no. 2, pp. 45–49, Aug. 2026, doi: 10.62243/edr.1918505.

ISNAD

Aydoğmuş, Gülsün - Akgül, Fatma Büşra - Nasiri, Elaheh. “Chemotherapy-Associated Osteonecrosis of the Jaw in Acute Lymphoblastic Leukemia: Report of a Rare Clinical Case”. Eurasian Dental Research 4/2 (August 1, 2026): 45-49. https://doi.org/10.62243/edr.1918505.

JAMA

1.Aydoğmuş G, Akgül FB, Nasiri E. Chemotherapy-Associated Osteonecrosis of the Jaw in Acute Lymphoblastic Leukemia: Report of a Rare Clinical Case. EDR. 2026;4:45–49.

MLA

Aydoğmuş, Gülsün, et al. “Chemotherapy-Associated Osteonecrosis of the Jaw in Acute Lymphoblastic Leukemia: Report of a Rare Clinical Case”. Eurasian Dental Research, vol. 4, no. 2, Aug. 2026, pp. 45-49, doi:10.62243/edr.1918505.

Vancouver

1.Gülsün Aydoğmuş, Fatma Büşra Akgül, Elaheh Nasiri. Chemotherapy-Associated Osteonecrosis of the Jaw in Acute Lymphoblastic Leukemia: Report of a Rare Clinical Case. EDR. 2026 Aug. 1;4(2):45-9. doi:10.62243/edr.1918505