Sideritis species in challenging against cancer: Cytotoxic, antiproliferative and apoptotic roles on different cancer cells

Year 2023, , 114 - 126, 30.12.2023

Önder Yumrutaş , Mustafa Pehlivan , Pınar Yumrutaş

https://doi.org/10.46239/ejbcs.1379553

Abstract

Sideritis species belonging to the Lamiaceae family are represented by many species around the world. They exhibit many bioactivities due to their important phytochemicals. They have remarkable bioactivities such as antioxidant, anticancer, antimicrobial, anti-inflammatory, etc. for important sectors such as pharmaceuticals and food. They are thought to be important resources in the fight against cancer, especially due to their cytotoxic effects on cancer cells. Many studies on various cancer cells have reported cytotoxic, antiproliferative and apoptotic properties of sideritis species. In this study, the phytochemical contents of sideritis species growing in different geographies and their cytotoxic, antiproliferative and apoptotic effects in the fight against cancer were discussed in detail molecularly.

Keywords

Sideritis, anticancer, antiproliferation, apoptosis, bioactivity

References

• Abdelhalim A, Hanrahan J. 2021. Chapter 7 - Biologically active compounds from Lamiaceae family: Central nervous system effects. Stud Nat Prod Chem. 8: 255-315.
• Altundag S, Aslim BELMA, Ozturk S. 2011. In vitro Antimicrobial Activities of Essential Oils from Origanum minutiflorum and Sideritis erytrantha subsp. erytrantha on Phytopathogenic Bacteria. J Essent Oil Res. 23: 4-8.
• Arıtuluk ZC, Ezer N. 2012. Halk arasında diyabete karşı kullanılan bitkiler Türkiye-II. HUJPHARM. 2:179- 208. Axiotis E, Petrakis EA, Halabalaki M, Mitakou S. 2020. Phytochemical profile and biological activity of endemic Sideritis sipylea Boiss. in North Aegean Greek islands. Molecules. 25: 2022.
• Aydoğmuş-Öztürk F, Günaydin K, Öztürk M, Jahan H, Duru ME, Choudhary MI. 2018. Effect of Sideritis leptoclada against HT-144 human malignant melanoma. Melanoma Res. 28. 502-509.
• Basile A, Senatore F, Gargano R, Sorbo S, Del Pezzo M, Lavitola A, Ritieni A, Bruno M, Spatuzzi D, Rigano D, Vuotto ML. 2006. Antibacterial and antioxidant activities in Sideritis italica (Miller) Greuter et Burdet essential oils. J Ethnopharmacol. 107: 240-248.
• Baytop T. 1999. Türkiye’de bitkiler ile tedavi (Geçmişte ve Bugün). İstanbul: Nobel Tıp Kitabevi. Brankovic S, Kitic D, Radenkovic M, Veljkovic S, Jankovic T, Savikin K, Zdunic G. 2011. Spasmolytic activity of the ethanol extract of Sideritis raeseri spp. raeseri Boiss. & Heldr. on the isolated rat ileum contractions. J Med Food. 14. 495-498.
• Carocho M, CFR Ferreira I. 2013. The role of phenolic compounds in the fight against cancer–a review. Anti-Cancer Agents Med Chem. 13:1236-1258.
• Çelik T, Önderci M, Pehlivan M, Yumrutaş Ö, Üçkardeş, F. 2021. In vitro scolicidal effects of Sideritis perfoliata extract against Echinococcus granulosus. Int J Clin Prat. 75: e14498.
• Chalatsa I, Arvanitis DA, Mikropoulou EV, Giagini A, Papadopoulou-Daifoti Z, Aligiannis N, halabalaki M, Tsarbopoulos A, Skaltsounis LA, Sanoudou D. 2018. Beneficial effects of Sideritis scardica and Cichorium spinosum against amyloidogenic pathway and tau misprocessing in Alzheimer’s disease neuronal cell culture models. J Alzheimer's Dis. 64: 787-800.
• Chen SL, Yu H, Luo HM, Wu Q, Li CF, Steinmetz A. 2016. Conservation and sustainable use of medicinal plants: problems, progress, and prospects. Chin Med. 11: 1-10.
• Chiarini A, Micucci M, Malaguti M, Budriesi R, Ioan P, Lenzi M, Fimognari C, Gallina Toschi T, Comandini P, Hrelia S. 2013. Sweet chestnut (Castanea sativa Mill.) bark extract: ardiovascular activity and myocyte protection against oxidative damage. Oxid Med Cell Longev. 471790.
• Cocelli G, Pehlivan M, Yumrutas O. 2021. Sideritis perfoliata inhibits cell proliferation, induces apoptosis and exhibits cellular antioxidant activity in cervical cancer cells. BLACPMA. 20:394-405
• Davis P. 1988. Flora of Turkey and The East Aegean Islands, Edinburgh University Press, Edinburgh. p. 178-179. Demirtas I, Sahin A, Ayhan B, Tekin S, Telci I. 2009. Antiproliferative effects of the methanolic extracts of Sideritis libanotica Labill. subsp. linearis. Rec Nat Prod. 3: 10-109.
• Deveci E, Tel‐Çayan G, Duru ME, Öztürk M. 2019. Phytochemical contents, antioxidant effects, and inhibitory activities of key enzymes associated with Alzheimer's disease, ulcer, and skin disorders of Sideritis albiflora and Sideritis leptoclada. J Food Biochem. 43: e13078.
• Deveci E, Tel-Çayan G, Duru ME. 2018. Phenolic profile, antioxidant, anticholinesterase, and anti-tyrosinase activities of the various extracts of Ferula elaeochytris and Sideritis stricta. Int J Food Prop. 21: 771-783.
• Dobrikova A, Gospodinova Z, Stefanov M, Apostolova E, Krasteva N. 2023. Phytochemıcal analysıs and assessment of the antioxıdant actıvıty and cytotoxıcıty potentıal of hydroethanolıc extract of bulgarıan Sıderıtıs scardıca. J Chem Technol Metall. 58:93-100
• Dziki D, Rozy ´ ło R, Gawlik-Dziki U, Swieca M. 2014. Current trends in the enhancement of antioxidant activity of wheat bread by the Addition of plant materials rich in phenolic compounds. Trends Food Sci Technol. 40: 48–61.
• Ege B, Yumrutas O, Ege M, Pehlivan M, Bozgeyik I. 2020 Pharmacological properties and therapeutic potential of saffron (Crocus sativus L.) in osteosarcoma. J Pharm Pharmacol. 72: 56-67.
• Erkan N, Cetin H, Ayranci E. 2011. Antioxidant activities of Sideritis congesta Davis et Huber-Morath and Sideritis arguta Boiss et Heldr: Identification of free flavonoids and cinnamic acid derivatives. Food Res Int. 44: 297-303.
• Ertas A, Yener I. 2020. A comprehensive study on chemical and biological profiles of three herbal teas in Anatolia; rosmarinic and chlorogenic acids. S Afr J Bot. 130: 274-281.
• Faiella L, Dal Piaz F, Bader A, Braca A. 2014. Diterpenes and phenolic compounds from Sideritis pullulans. Phytochem. 106: 164-170.
• Göktaş Ö, Gıdık B. 2019. Tıbbi ve Aromatik Bitkilerin Kullanım Alanları. Bayburt Üniversitesi Fen Bilimleri Dergisi, 2:145-151.
• González-Burgos E, Carretero M, Gómez-Serranillos M. 2011. Sideritis spp.: uses, chemical composition and pharmacological activities—a review. J Ethnopharmacol. 135: 209-225.
• Goulas V, Exarchou V, Kanetis L, Gerothanassis IP. 2014. Evaluation of the phytochemical content, antioxidant activity and antimicrobial properties of mountain tea (Sideritis syriaca) decoction. J Funct Food. 6: 248-258.
• Gregory J, Vengalasetti YV, Bredesen DE, Rao RV. 2021 Neuroprotective herbs for the management of Alzheimer's Disease. Biomolecules. 11: 543.
• Güvenç A, Okada Y, Akkol EK, Duman H, Okuyama T, Çalış İ. 2010. Investigations of anti-inflammatory, antinociceptive, antioxidant and aldose reductase inhibitory activities of phenolic compounds from Sideritis brevibracteata. Food Chem. 118: 686-692.
• He J, Yang B, Dong M, Wang Y. 2018. Crossing the roof of the world: Trade in medicinal plants from Nepal to China. J Ethnopharmacol. 224: 100-110.
• Hernández-Pérez M, Rabanal Gallego RM. 2002. Analgesic and antiinflammatory properties of Sideritis lotsyi var. Mascaensis. Phytother Res. 16(3):264-266.
• Melikoğlu G, Kurtoğlu S, Kültür Ş. 2015. Türkiye’de astım tedavisinde geleneksel olarak kullanılan bitkiler, Marmara Pharm J19: 1-11.
• Mitropoulou G, Sidira M, Skitsa M, Tsochantaridis I, Pappa A, Dimtsoudis C, Proestos C, Kourkoutas Y. 2020. Assessment of the antimicrobial, antioxidant, and antiproliferative potential of Sideritis raeseri subps. raeseri essential oil. Foods. 9: 860.
• Öke F. 2006. Türkiye Sideritis L. (Labiatae) Türlerinin Tohum Protein Analizleri. Gazi Üniversitesi Fen Bilimleri Enstitüsü (Biyoloji Bölümü) Yüksek Lisans Tezi, 60 s. Ankara.
• Oun R, Moussa YE, Wheate NJ. 2018. The side effects of platinum-based chemotherapy drugs: a review for chemists. Dalton Trans. 47: 6645-6653.
• Öztürk M, Uysal İ, Gücel S, Altundağ E, Doğan Y, Başlar S. 2013 Türkiye'de doğal boya veren bitkilerin tıbbi kullanımları, Tekstil ve Konfeksiyon Araştırma Dergisi. 17: 69-80.
• Poon IK, Lucas CD, Rossi AG, Ravichandran KS. 2014. Apoptotic cell clearance: basic biology and therapeutic potential. Nat Rev Immunol. 14(3), 166-180.
• Rabi T, Bishayee A. 2009. Terpenoids and breast cancer chemoprevention. Breast Cancer Res Treat. 115: 223-239.
• Sagdic O, Aksoy A, Ozkan G, Ekici L, Albayrak S. 2008. Biological activities of the extracts of two endemic Sideritis species in Turkey. IFSET. 9: 80-84.
• Sagir ZO, Carikci S, Kilic T, Goren AC. 2017. Metabolic profile and biological activity of Sideritis brevibracteata PH Davis endemic to Turkey. Int J Food Prop. 20: 2994-3005.
• Sato F, Wong CP, Furuya K, Kuzu C, Kimura R, Udo T, Honda H, Yang J. 2022. Anti-skin Aging Activities of Sideritis scardica and 3 Flavonoids with an Uncommon 8-Hydroxyl Moiety. Nat Pro Commun.17: 1934578X221094910.
• Savitskaya MA, Onishchenko GE. 2015. Mechanisms of apoptosis. Biochem. 2015;80: 1393-1405. Sezer ENŞ, Uysal T. 2021. Phytochemical analysis, antioxidant and anticancer potential of Sideritis niveotomentosa: Endemic Wild Species of Turkey. Molecules. 26: 2420.
• Sezer ENŞ, Uysal T. 2019. The Effects of the Sideritis ozturkii Extract on the Expression Levels of some Apoptotic Genes. CUPMAP. 1: 8-12..
• Siegel RL, Miller KD, Wagle NS, Jemal A. 2023. Cancer statistics, 2023. Ca Cancer J Clin. 73: 17-48.
• Tamokou JDD, Mbaveng AT, Kuete V. 2017. Antimicrobial Activities of African Medicinal Spices and Vegetables, Medicinal Spices and Vegetables from Africa, Chapter 8, 207-237.
• Tomou EM, Chatziathanasiadou MV, Chatzopoulou P, Tzakos AG, Skaltsa. 2020. NMR-Based Chemical Profiling, Isolation and Evaluation of the Cytotoxic Potential of the Diterpenoid Siderol from Cultivated Sideritis euboea Heldr. Molecules. 25: 2382.
• Tóth B, Kúsz N, Forgo P, Bózsity N, Zupkó I, Pinke G, Hohmann J, Vasas A. 2017. Abietane diterpenoids from Sideritis montana L. and their antiproliferative activity. Fitoterapia. 122: 90-94.
• Trivellini A, Lucchesini M, Maggini R, Mosadegh H, Villamarin TSS, Vernieri P, ...Mensuali-Sodi A, Pardossi A. 2016. Lamiaceae phenols as multifaceted compounds: Bioactivity, industrial prospects and role of “positive-stress”. Ind Crops Prod. 83: 241-254.
• Uritu CM, Mihai CT, Stanciu GD, Dodi G, Alexa-Stratulat T, Luca A, Leon Constantin MM, Stefanescu R, Bild V, Melnic S, Tamba BI. 2018. Medicinal plants of the family Lamiaceae in pain therapy: A review, Pain Res Manag. 7801543.
• Van Engeland M, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP. 1998. Annexin V‐affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry: j Int Soc Anal Cytol. 31: 1-9.
• Ververis A, Ioannou K, Kyriakou S, Violaki N, Panayiotidis MI, Plioukas M, Christodoulou K. 2023. Sideritis scardica Extracts Demonstrate Neuroprotective Activity against Aβ25-35 Toxicity. Plants (Basel).12(8):1716. Yeşilada E, Honda G, Sezik E, Tabata M, Fujita T, Tanaka T, Takeda Y, Takaishi Y. 1995. Traditional medicine in Turkey. V. Folk medicine in the inner Taurus Mountains. J Ethnopharmacol. 46, 133-152.
• Yumrutas O, Bozgeyik I. 2023, Anticancer activity of Inula graveolens by induction of ROS-independent apoptosis and suppression of IL6-IL8 in cervical cancer cells. BLACPMA. 22:314-325
• Yumrutas O, Oztuzcu S, Pehlivan M, Ozturk N, Poyraz IE, Igci YZ, Cevik MO, Bozgeyik I, Aksoy AF, Bagıs H, Arslan A. 2015. Cell viability, anti-proliferation and antioxidant activities of Sideritis syriaca, Tanacetum argenteum sub sp. argenteum and Achillea aleppica subsp. zederbaueri on human breast cancer cell line (MCF-7). J Appl Pharm Sci. 5: 001-005.
• Yumrutas O, Saygideger SD, Sokmen M. 2012. DNA protection and antioxidant activities of Ajuga chamaeptys (L.) schreber essential oil and its volatile compounds. J Essent Oil Bear Plants. 15, 526-530. Yumrutas O, Saygideger SD. 2012. Determination of antioxidant and antimutagenic activities of Phlomis armeniaca and Mentha pulegium. JAppl Pharm Sci. 2:36-40
• Yumrutaş Ö, Yumrutaş P. 2022. Phenolic compounds that modulate Multi Drug Resistance through inhibiting of P-glycoprotein encoded by gene ABCB1. Eurasian J Biol Chem. Sci. 5: 162-165.
• Zengin G, Uğurlu A, Baloglu MC, Diuzheva A, Jekő J, Cziáky Z, Ceylan R, Aktumsek A, Picot-Allain CMN, Mahomoodally MF. , 2019. Chemical fingerprints, antioxidant, enzyme inhibitory, and cell assays of three extracts obtained from Sideritis ozturkii Aytaç & Aksoy: An endemic plant from Turkey. J Pharm Biomed Anal 171: 118-125.
• Zhang Y, Wang, Y. 2023. Recent trends of machine learning applied to multi-source data of medicinal plants. J Pharm Anal. In press.