Relationship of Nematodes and Humans in Prehistoric Times: A Paleoparasitological Perspective

Year 2025, Volume: 8 Issue: 2, 118 - 124, 29.12.2025

Caner Övet

https://doi.org/10.46239/ejbcs.1761235

Abstract

In analogy to microorganisms, from free-living to the parasites, phylum of nematods take up a great range in ecological niches on the earth. As an evolutionary result of interactions between humans and nematodes, some species have evolved a parasitic life cycle. It is estimated that major infectious conditions of early hominids and prehistorical humans was parasitic infections. Adaptations and both human and parasite immune system composed an evolutionary interaction that called “co-evolution”. As a multidisciplinary science paleoparasitology is also considered a branch of paleopathology. Although investigate human remnants such as bones are extensively useful in paleopathology, they are not suitable to track parasites. Hence, paleoparasitology rather investigate remnants such as coprolites and intestinal contents. Paleoparasitological findings have importance to understand hygiene conditions, health issues and predictions on dietary consumption of human ancestors. In contrast to ancient and modern civilizations, major health problem of prehistoric humans were parasitic infections caused by helminths. Those infections introduced to humans as they migrated to new regions or they were existed already which called “heirloom parasites”. Evidences of parasitic helminths in humans have widely recorded around the earth. Aims of present review are elucidate human-nematode inter-actions during prehistoric times and overview that co-evolution.

Keywords

nematodes , prehistoria , co-evolution , heirloom parasite , human evolution , paleoparasitology

References

• Allison MJ, Pezzia A, Hasegawa I, Gerszten E. 1974. A case of hookworm infestation in a pre-Columbian American. Am J Phys Anthropol. 41(1):103–106.
• Araújo A, Ferreira LF, Confalonieri U, Chame M. 1988. Hookworms and the peopling of America. Cad Saúde Pública. 4:226–233.
• Araújo A, Ferreira LF, Fugassa M, Leles D, Sianto L, de Souza SMM, Dutra J, Iñiguez A, Reinhard K. 2016. New world paleoparasitology. In: Sanitation, latrines and intestinal parasites in past populations. Routledge, pp 165–202.
• Araújo A, Reinhard K, Bastos OM, Costa LC, Pirmez C, Iñiguez A, Vicente AC, Morel CM, Ferreira LF. 1998. Paleoparasitology: perspectives with new techniques. Rev Inst Med Trop São Paulo. 40:371–376.
• Araujo A, Reinhard KJ, Ferreira LF, Gardner SL. 2008. Parasites as probes for prehistoric human migrations? Trends Parasitol. 24(3):112–115.
• Araújo A, Reinhard KJ, Gardner SL, Ferreira LF. 2014. Parasites as markers of prehistoric migrations. In: Foundations of paleoparasitology. p 141.
• Bergman J. 2018. Stone age disease in the north: human intestinal parasites from a Mesolithic burial in Motala, Sweden. J Archaeol Sci. 96:26–32.
• Blaxter M. 2000. Genes and genomes of Necator americanus and related hookworms. Int J Parasitol. 30(4):347–355.
• Bouchet F, Lefèvre C, West D, Corbett D. 1999. First paleoparasitological analysis of a midden in the Aleutian Islands (Alaska): results and limits. J Parasitol. 85:369–372.
• Buikstra JE. 2019. Ortner’s identification of pathological conditions in human skeletal remains.
• Callen EO, Cameron TW. 1960. A prehistoric diet revealed in coprolites. Cockburn TA. 1973. Death and disease in ancient Egypt. Science. 181(4098):470–471.
• Côté NM-L, Le Bailly M. 2018. Palaeoparasitology and palaeogenetics: review and perspectives for the study of ancient human parasites. Parasitology. 145(5):656–664.
• de Souza MV, da Silva LGR, Silva-Pinto V, Mendez-Quiros P, de Miranda Chaves SA, Iñiguez AM. 2018. New paleoparasitological investigations from the pre-Inca to Hispanic contact period in northern Chile. Acta Trop. 178:290–296.
• Dommelier-Espejo S. 2001. Contribution à l’étude paléoparasitologique des sites néolithiques en environnement lacustre dans les domaines jurassien et péri-alpin. Doktora tezi. University of Reims Champagne-Ardenne, Reims.
• Dusseau E, Porter R. 1974. The search for animal parasites in paleofeces from Upper Salts Cave. In: Watson PJ (ed) Archaeology of the Mammoth Cave Area. Academic Press, New York.
• Faulkner C, Patton S. 1990. Prehistoric parasitism in Tennessee.
• Faulkner CT, Patton S. 2001. Pre-Columbian hookworm evidence from Tennessee: a response to Fuller (1997). Med Anthropol. 20(1):92–96.
• Ferreira L, Araújo A, Confalonieri U, Chame M, Ribeiro Filho B. 1987. The finding of hookworm eggs in human coprolites from 7230±80 years BP, Piauí, Brazil. An Acad Bras Cienc. 59:280–281.
• Ferreira LF. 1973. O fenômeno parasitismo. Rev Soc Bras Med Trop. 7:261–277.
• Ferreira LF, Araújo A, Confalonieri U, Nuñez L. 1989. Infecção por Enterobius vermicularis em populações agro-pastoris pré-colombianas de San Pedro de Atacama, Chile. Mem Inst Oswaldo Cruz. 84:197–199.
• Ferreira LF, de Araújo AJ, Confalonieri UE. 1983. The finding of helminth eggs in a Brazilian mummy. Trans R Soc Trop Med Hyg. 77(1):65–67.
• Ferreira LF, de Araújo AJ, Confalonieri U. 1980. The finding of eggs and larvae of parasitic helminths in archaeological material from Unai, Minas Gerais, Brazil. Trans R Soc Trop Med Hyg. 74(6):798–800.
• Ferreira LF, Reinhard KJ, Araújo A. 2014. The origin of parasites of humans. In: Foundations of paleoparasitology. p 121.
• Flores-Ponce M, Vallebueno-Estrada M, González-Orozco E, Ramos-Aboites HE, García-Chávez JN, Simões N, Montiel R. 2017. Signatures of co-evolutionary host–pathogen interactions in the genome of Steinernema carpocapsae. BMC Evol Biol. 17:1–14.
• Fornaciari G, Gaeta R. 2014. Paleoparasitology of helminths. In: Helminth infections and their impact on global public health. Springer, pp 29–47.
• Fry GF. 1985. Analysis of fecal material. In: The analysis of prehistoric diets. p 154.
• Fry GF, Hall H. 1969. Parasitological examination of prehistoric human coprolites from Utah.
• Fry GF, Moore JG. 1969. Enterobius vermicularis: 10,000-year-old human infection. Science. 166(3913):1620.
• Fugassa M, Denegri G, Sardella N. 2006. Paleoparasitological records in a canid coprolite from Patagonia, Argentina. J Parasitol. 92(5):1110–1113.
• Fulton TL, Stiller M. 2011. PCR amplification, cloning, and sequencing of ancient DNA. In: Ancient DNA: methods and protocols. Springer, pp 111–119.
• Gaeta R, Fornaciari G. 2022. Paleoparasitology of helminths. In: Helminth infections and their impact on global public health. Springer, pp 73–101.
• Gonçalves MLC, Araújo A, Ferreira LF. 2003. Human intestinal parasites in the past: new findings and a review. Mem Inst Oswaldo Cruz. 98:103–118.
• Guernier V, Hochberg ME, Guégan JF. 2004. Ecology drives the worldwide distribution of human diseases. PLoS Biol. 2(6):e141.
• Iñiguez AM, Reinhard KJ, Araújo A, Ferreira LF, Vicente ACP. 2003. Enterobius vermicularis: ancient DNA from North and South American human coprolites. Mem Inst Oswaldo Cruz. 98:67–69.
• Jiménez FA, Gardner SL, Araújo A, Fugassa M, Brooks RH, Racz E, Reinhard KJ. 2012. Zoonotic and human parasites of inhabitants of Cueva de los Muertos Chiquitos, Durango, Mexico. J Parasitol. 98(2):304–309. Katzourakis A. 2017. Editorial overview: paleovirology. Curr Opin Virol. 25.
• Kiontke K, Fitch DH. 2013. Nematodes. Curr Biol. 23(19):R862–R864.
• Ledger ML, Anastasiou E, Shillito L-M, Mackay H, Bull ID, Haddow SD, Knüsel CJ, Mitchell PD. 2019. Parasite infection at the early farming community of Çatalhöyük. Antiquity. 93(369):573–587.
• Ledger ML, Mitchell PD. 2022. Tracing zoonotic parasite infections throughout human evolution. Int J Osteoarchaeol. 32(3):553–564.
• Mitchell PD. 2013. The origins of human parasites. Int J Paleopathol. 3(3):191–198.
• Mitchell PD. 2024. Ancient parasite analysis: exploring infectious diseases in past societies. J Archaeol Sci. 170:106067.
• Mitchell PD, Yeh H-Y, Appleby J, Buckley R. 2013. The intestinal parasites of King Richard III. Lancet. 382(9895):888.
• Novo SPC, Ferreira LF. 2016. Paleoparasitology in Brazil. Korean J Parasitol. 54(5):573.
• Nozais J-P. 2003. The origin and dispersion of human parasitic diseases in the Old World. Mem Inst Oswaldo Cruz. 98:13–19.
• Pearce-Duvet JM. 2006. The origin of human pathogens. Biol Rev. 81(3):369–382.
• Reinhard KJ. 1990. Archaeoparasitology in North America. Am J Phys Anthropol. 82(2):145–163.
• Reinhard KJ, Araújo A, Ferreira LF, Coimbra CE. 2001. American hookworm antiquity. Med Anthropol. 20(1):96–101.
• Szidat L. 1944. Über die Erhaltungsfähigkeit von Helmintheneiern. Z Parasitenkd. 13:265–274.
• van der Kuyl AC. 2022. Historic and prehistoric epidemics. Epidemiologia. 3(4):443–464.
• Zeuner FE. 1963. A history of domesticated animals.