Cu katkılı biyocam ve Cu nanoparçacıklı Sr katkılı biyocamdan 3D kompozit yapı iskelesi üretimi

Abstract

Bu çalışmada, çözücü döküm ve tanecik uzaklaştırma yöntemi kullanılarak, çok işlevli yapı iskelelerinin geliştirilmesi için ilgili iyonlarla BG / polimer 3D kompozit yapı iskelelerinin üretilmesi amaçlanmıştır. Gözenekli yapıya sahip yapı iskeleleri başarıyla sentezlenmiş ve yapı iskelelerinin mikroyapısında iyi bir gözenek bağlantısının bulunduğu gözlemlenmiştir. Kompozit yapı iskelelerinin in vitro biyoaktivitesi; Taramalı Elektron Mikroskopisi (SEM), X-ışını kırınımı ve Fourier-Dönüşümlü Kızılötesi Spektroskopi ölçümleri ile teyit edilmiştir. Bunun dışında, terapatik iyonların salımının; SBF'de kalma sürelerinin bir fonksiyonu olarak, Sr iyon salımı 1.27-4.81 ppm aralığında iken, Cu iyon salımları sırasıyla, Cu katkılı BG için 0.67-1.42 ppm, Sr katkılı BG-%1 Cu için 1.53-4.54 ppm,  Sr katkılı BG-%2 Cu için 3.08-7.59 ppm olarak saptanmıştır. Bu sonuç yapı iskelelerinin, kemik dokusu rejenerasyonunun belirleyicisi olan SBF ortamına, stronsiyum ve bakır dozlarını kontrollü olarak verebileceğini göstermiştir.

Keywords

• Kompozit yapı iskelesi,biyoaktif cam,terapatik iyonlar

3D composite scaffold production using Cu doped bioglass and Sr doped bioglass with Cu nanoparticles

Abstract

In this study, it was aimed to produce BG/polymer 3D composite scaffolds with relevant ions in order to develop multifunctional scaffolds by using salt template-particulate leaching technique. The porous scaffolds were successfully synthesized and it was observed that there was a good pore interconnectivity maintained in the scaffold microstructure. In vitro bioactivity of the composite scaffolds was confirmed by Scanning Electron Microscopy, X-ray diffraction and Fourier-Transform Infrared Spectroscopy measurements. Furthermore, the release of therapeutic ions were determined as a function of immersion time in SBF, while the Sr ion release is in the range of 1.27-4.81 ppm, the Cu ion releases are 0.67-1.42 ppm for Cu doped BG, 1.53-4.54 ppm for Sr doped BG- 1% Cu, and 3.08-7.59 ppm for Sr doped BG- 2% Cu, respectively. This result indicated that the scaffolds can deliver controlled doses of strontium and copper toward the SBF medium that is the determinant for bone tissue regeneration.

Keywords

• Composite scaffold,bioactive glass,theraupatic ions

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